Zobrazeno 1 - 10
of 906
pro vyhledávání: '"David A. Siscovick"'
Autor:
David Bleich, Mary L. Biggs, Julius M. Gardin, Mary Lyles, David S. Siscovick, Kenneth J. Mukamal
Publikováno v:
American Journal of Preventive Cardiology, Vol 19, Iss , Pp 100725- (2024)
Aims: To determine whether discrete lipid profiles (refer to as lipid phenotyping) can be used to stratify cardiovascular risk in individuals with type 2 diabetes. Methods and results: Cardiovascular Health Study participants with diabetes and fastin
Externí odkaz:
https://doaj.org/article/cca9dd1d9c50402982bbf491eb0e77b5
Autor:
Amanda M. Fretts, Paul N. Jensen, Colleen M. Sitlani, Andy Hoofnagle, Benjamin Lidgard, Jason G. Umans, David S. Siscovick, Irena B. King, Barbara V. Howard, Shelley A. Cole, Rozenn N. Lemaitre
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 13 (2024)
Background A growing body of research indicates that associations of ceramides and sphingomyelins with mortality depend on the chain length of the fatty acid acylated to the backbone sphingoid base. We examined associations of 8 ceramide and sphingom
Externí odkaz:
https://doaj.org/article/ae8a9bcf773c4ab598ad1715e39a325f
Autor:
Yakubu Bene-Alhasan, David S. Siscovick, Joachim H. Ix, Jorge R. Kizer, Russell Tracy, Luc Djoussé, Kenneth J. Mukamal
Publikováno v:
Metabolism Open, Vol 20, Iss , Pp 100261- (2023)
Aim: Non-esterified fatty acids (NEFA) are potential targets for prevention of key cardiometabolic diseases of aging, but their population-level correlates remain uncertain. We sought to identify modifiable factors associated with fasting and post-lo
Externí odkaz:
https://doaj.org/article/cbc5808248194217883512bd3a19b031
Autor:
Benjamin Lidgard, Nisha Bansal, Leila R. Zelnick, Andrew N. Hoofnagle, Amanda M. Fretts, William T. Longstreth, Jr., Michael G. Shlipak, David S. Siscovick, Jason G. Umans, Rozenn N. Lemaitre
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104765- (2023)
Summary: Background: Sphingolipids are a family of circulating lipids with regulatory and signaling roles that are strongly associated with both eGFR and cardiovascular disease. Patients with chronic kidney disease (CKD) are at high risk for cardiova
Externí odkaz:
https://doaj.org/article/c8863ab2b9c6472a93ed61fcec604af9
Autor:
Rozenn N. Lemaitre, Paul N. Jensen, Zeneng Wang, Amanda M. Fretts, Colleen M. Sitlani, Ina Nemet, Nona Sotoodehnia, Marcia C. de Oliveira Otto, Weifei Zhu, Matt Budoff, W. T. Longstreth, Bruce M. Psaty, David S. Siscovick, Stanley L. Hazen, Dariush Mozaffarian
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 16 (2023)
Background The association of circulating trimethylamine‐N‐oxide (TMAO) with stroke has received limited attention. To address this gap, we examined the associations of serial measures of plasma TMAO with incident ischemic stroke. Methods and Res
Externí odkaz:
https://doaj.org/article/43e934b0c5ff4a778dac6634de13e4b3
Autor:
Paul N. Jensen, Amanda M. Fretts, Andrew N. Hoofnagle, Barbara McKnight, Barbara V. Howard, Jason G. Umans, Colleen M. Sitlani, David S. Siscovick, Irena B. King, Nona Sotoodehnia, Rozenn N. Lemaitre
Publikováno v:
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-10 (2022)
Abstract Background Plasma ceramides and sphingomyelins have been independently linked to diabetes risk, glucose and insulin levels, and the risk of several cardiovascular (CVD) outcomes. However, whether individual ceramide and sphingomyelin species
Externí odkaz:
https://doaj.org/article/54129391a2444a28a02c387c62d4d169
Autor:
Rozenn N. Lemaitre, Paul N. Jensen, Maxwell Zeigler, Amanda M. Fretts, Jason G. Umans, Barbara V. Howard, Colleen M. Sitlani, Barbara McKnight, Sina A. Gharib, Irena B. King, David S. Siscovick, Bruce M. Psaty, Nona Sotoodehnia, Rheem A. Totah
Publikováno v:
EBioMedicine, Vol 83, Iss , Pp 104189- (2022)
Summary: Background: Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid that may impact atherosclerosis, and animal experimental studies suggest EETs protect cardiac function. Plasma EETs are mostly esterified to phospholipids and p
Externí odkaz:
https://doaj.org/article/2df301d177d4451f903cbf396c53c760
Autor:
Julio A. Lamprea‐Montealegre, Alice M. Arnold, Robyn L. McCLelland, Kenneth J. Mukamal, Luc Djousse, Mary L. Biggs, David S. Siscovick, Russell P. Tracy, Paul J. Beisswenger, Bruce M. Psaty, Joachim H. Ix, Jorge R. Kizer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 15 (2022)
Background Advanced glycation endproducts (AGEs) have been linked to cardiovascular disease (CVD) in cohorts with and without diabetes. Data are lacking on prospective associations of various α‐dicarbonyl‐derived AGEs and incident CVD in the gen
Externí odkaz:
https://doaj.org/article/885ccc568011426bb09a4f00a37815f9
Autor:
William S. Harris, Nathan L. Tintle, Fumiaki Imamura, Frank Qian, Andres V. Ardisson Korat, Matti Marklund, Luc Djoussé, Julie K. Bassett, Pierre-Hugues Carmichael, Yun-Yu Chen, Yoichiro Hirakawa, Leanne K. Küpers, Federica Laguzzi, Maria Lankinen, Rachel A. Murphy, Cécilia Samieri, Mackenzie K. Senn, Peilin Shi, Jyrki K. Virtanen, Ingeborg A. Brouwer, Kuo-Liong Chien, Gudny Eiriksdottir, Nita G. Forouhi, Johanna M. Geleijnse, Graham G. Giles, Vilmundur Gudnason, Catherine Helmer, Allison Hodge, Rebecca Jackson, Kay-Tee Khaw, Markku Laakso, Heidi Lai, Danielle Laurin, Karin Leander, Joan Lindsay, Renata Micha, Jaako Mursu, Toshiharu Ninomiya, Wendy Post, Bruce M. Psaty, Ulf Risérus, Jennifer G. Robinson, Aladdin H. Shadyab, Linda Snetselaar, Aleix Sala-Vila, Yangbo Sun, Lyn M. Steffen, Michael Y. Tsai, Nicholas J. Wareham, Alexis C. Wood, Jason H. Y. Wu, Frank Hu, Qi Sun, David S. Siscovick, Rozenn N. Lemaitre, Dariush Mozaffarian, The Fatty Acids and Outcomes Research Consortium (FORCE)
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Associations between of omega-3 fatty acids and mortality are not clear. Here the authors report that, based on a pooled analysis of 17 prospective cohort studies, higher blood omega-3 fatty acid levels correlate with lower risk of all-cause mortalit
Externí odkaz:
https://doaj.org/article/812a00b619f34cb996b3f37722f44665
Autor:
Vasiliki Lagou, Reedik Mägi, Jouke- Jan Hottenga, Harald Grallert, John R. B. Perry, Nabila Bouatia-Naji, Letizia Marullo, Denis Rybin, Rick Jansen, Josine L. Min, Antigone S. Dimas, Anna Ulrich, Liudmila Zudina, Jesper R. Gådin, Longda Jiang, Alessia Faggian, Amélie Bonnefond, Joao Fadista, Maria G. Stathopoulou, Aaron Isaacs, Sara M. Willems, Pau Navarro, Toshiko Tanaka, Anne U. Jackson, May E. Montasser, Jeff R. O’Connell, Lawrence F. Bielak, Rebecca J. Webster, Richa Saxena, Jeanette M. Stafford, Beate St Pourcain, Nicholas J. Timpson, Perttu Salo, So-Youn Shin, Najaf Amin, Albert V. Smith, Guo Li, Niek Verweij, Anuj Goel, Ian Ford, Paul C. D. Johnson, Toby Johnson, Karen Kapur, Gudmar Thorleifsson, Rona J. Strawbridge, Laura J. Rasmussen-Torvik, Tõnu Esko, Evelin Mihailov, Tove Fall, Ross M. Fraser, Anubha Mahajan, Stavroula Kanoni, Vilmantas Giedraitis, Marcus E. Kleber, Günther Silbernagel, Julia Meyer, Martina Müller-Nurasyid, Andrea Ganna, Antti-Pekka Sarin, Loic Yengo, Dmitry Shungin, Jian’an Luan, Momoko Horikoshi, Ping An, Serena Sanna, Yvonne Boettcher, N. William Rayner, Ilja M. Nolte, Tatijana Zemunik, Erik van Iperen, Peter Kovacs, Nicholas D. Hastie, Sarah H. Wild, Stela McLachlan, Susan Campbell, Ozren Polasek, Olga Carlson, Josephine Egan, Wieland Kiess, Gonneke Willemsen, Johanna Kuusisto, Markku Laakso, Maria Dimitriou, Andrew A. Hicks, Rainer Rauramaa, Stefania Bandinelli, Barbara Thorand, Yongmei Liu, Iva Miljkovic, Lars Lind, Alex Doney, Markus Perola, Aroon Hingorani, Mika Kivimaki, Meena Kumari, Amanda J. Bennett, Christopher J. Groves, Christian Herder, Heikki A. Koistinen, Leena Kinnunen, Ulf de Faire, Stephan J. L. Bakker, Matti Uusitupa, Colin N. A. Palmer, J. Wouter Jukema, Naveed Sattar, Anneli Pouta, Harold Snieder, Eric Boerwinkle, James S. Pankow, Patrik K. Magnusson, Ulrika Krus, Chiara Scapoli, Eco J. C. N. de Geus, Matthias Blüher, Bruce H. R. Wolffenbuttel, Michael A. Province, Goncalo R. Abecasis, James B. Meigs, G. Kees Hovingh, Jaana Lindström, James F. Wilson, Alan F. Wright, George V. Dedoussis, Stefan R. Bornstein, Peter E. H. Schwarz, Anke Tönjes, Bernhard R. Winkelmann, Bernhard O. Boehm, Winfried März, Andres Metspalu, Jackie F. Price, Panos Deloukas, Antje Körner, Timo A. Lakka, Sirkka M. Keinanen-Kiukaanniemi, Timo E. Saaristo, Richard N. Bergman, Jaakko Tuomilehto, Nicholas J. Wareham, Claudia Langenberg, Satu Männistö, Paul W. Franks, Caroline Hayward, Veronique Vitart, Jaakko Kaprio, Sophie Visvikis-Siest, Beverley Balkau, David Altshuler, Igor Rudan, Michael Stumvoll, Harry Campbell, Cornelia M. van Duijn, Christian Gieger, Thomas Illig, Luigi Ferrucci, Nancy L. Pedersen, Peter P. Pramstaller, Michael Boehnke, Timothy M. Frayling, Alan R. Shuldiner, Patricia A. Peyser, Sharon L. R. Kardia, Lyle J. Palmer, Brenda W. Penninx, Pierre Meneton, Tamara B. Harris, Gerjan Navis, Pim van der Harst, George Davey Smith, Nita G. Forouhi, Ruth J. F. Loos, Veikko Salomaa, Nicole Soranzo, Dorret I. Boomsma, Leif Groop, Tiinamaija Tuomi, Albert Hofman, Patricia B. Munroe, Vilmundur Gudnason, David S. Siscovick, Hugh Watkins, Cecile Lecoeur, Peter Vollenweider, Anders Franco-Cereceda, Per Eriksson, Marjo-Riitta Jarvelin, Kari Stefansson, Anders Hamsten, George Nicholson, Fredrik Karpe, Emmanouil T. Dermitzakis, Cecilia M. Lindgren, Mark I. McCarthy, Philippe Froguel, Marika A. Kaakinen, Valeriya Lyssenko, Richard M. Watanabe, Erik Ingelsson, Jose C. Florez, Josée Dupuis, Inês Barroso, Andrew P. Morris, Inga Prokopenko, Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Sex differences in fasting glucose and insulin have been identified, but the genetic loci underlying these differences have not. Here, the authors perform a meta-analysis of genome-wide association studies to detect sex-specific and sex-dimorphic loc
Externí odkaz:
https://doaj.org/article/7959f93136b14448a7811855feb4fcf6