Zobrazeno 1 - 10
of 110
pro vyhledávání: '"David A. Self"'
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
The consequence of repeated cocaine exposure and prolonged abstinence on glutamate receptor expression in the nucleus accumbens has been extensively studied. However, the early effects of cocaine on NMDAR signaling remain unknown. NMDAR signaling dep
Externí odkaz:
https://doaj.org/article/4e7ea845737041a98987d5f87133bd45
Publikováno v:
Frontiers in Neuroanatomy, Vol 5 (2011)
Drug addiction is a severe neuropsychiatric disorder characterized by loss of control over motivated behavior. The need for effective treatments mandates a greater understanding of the causes and identification of new therapeutic targets for drug dev
Externí odkaz:
https://doaj.org/article/c67a46c830f74888b78ffb25e1facac9
Autor:
David W. Self, Ethan M. Anderson, Eric J. Nestler, Anne Marie Wissman, Erin B. Larson, Daniel Guzman, Rachael L. Neve
Publikováno v:
The Journal of Neuroscience. 38:803-813
Repeated exposure to cocaine induces lasting epigenetic changes in neurons that promote the development and persistence of addiction. One epigenetic alteration involves reductions in levels of the histone dimethyltransferase G9a in nucleus accumbens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746413559974fbbb9450b5f651b90681
https://doi.org/10.1523/jneurosci.1657-17.2017
https://doi.org/10.1523/jneurosci.1657-17.2017
Autor:
Anne Marie Wissman, Joyce Chemplanikal, Nicole Buzin, Erin B. Larson, Daniel Guzman, David W. Self, Ethan M. Anderson, Christopher W. Cowan, Rachael L. Neve, Eric J. Nestler
Publikováno v:
Proceedings of the National Academy of Sciences. 114:9469-9474
Chronic cocaine use is associated with prominent morphological changes in nucleus accumbens shell (NACsh) neurons, including increases in dendritic spine density along with enhanced motivation for cocaine, but a functional relationship between these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f08cc52e2f7f40db61819bf7b50773
https://doi.org/10.1073/pnas.1702441114
https://doi.org/10.1073/pnas.1702441114
Publikováno v:
Pharmacology Biochemistry and Behavior. 159:12-17
Prior studies have shown that drug-seeking behaviors increase, rather than dissipate, over weeks to months after withdrawal from drug self-administration. This phenomenon - termed incubation - suggests that drug-craving responses elicited by conditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6efce212c76d289114593da74aa92277
https://doi.org/10.1016/j.pbb.2017.06.017
https://doi.org/10.1016/j.pbb.2017.06.017
Autor:
David W. Self, Ethan M. Anderson
Publikováno v:
Current Opinion in Behavioral Sciences. 13:117-123
Many reports show that repeated cocaine administration increases dendritic spine density in medium spiny neurons of the nucleus accumbens, but there is less agreement regarding the persistence of these changes. In this review we examine these discrep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1436592fcb84d524eb9aa7286b4b56b1
https://doi.org/10.1016/j.cobeha.2016.11.013
https://doi.org/10.1016/j.cobeha.2016.11.013
Autor:
David W. Self
Publikováno v:
Pharmacology, biochemistry, and behavior. 174
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a78aee2879c93830f4465baa858bb2
https://pubmed.ncbi.nlm.nih.gov/30342591
https://pubmed.ncbi.nlm.nih.gov/30342591
Autor:
Makoto Taniguchi, Daniel Guzman, Ethan M. Anderson, Christopher W. Cowan, Ian Maze, HaoSheng Sun, David W. Self, Eric J. Nestler
Publikováno v:
Neuropsychopharmacology
Comorbid neuropsychiatric disorders such as addiction and anxiety could involve common underlying mechanisms. One potential mechanism involves epigenetic regulation of histone 3 dimethylation at lysine 9 residues (H3K9me2) by the histone dimethyltran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e8d413da95439ccfbac6d5a2339e43
https://pubmed.ncbi.nlm.nih.gov/30760826
https://pubmed.ncbi.nlm.nih.gov/30760826
Autor:
Rachel N. Arey, Edgardo Falcon, Alexandria L. Nugent, Sade Spencer, Alan Twaddle, Colleen A. McClung, Shibani Mukherjee, Andrea G. Gillman, David W. Self, Angela R. Ozburn, James Lyons-Weiler
Publikováno v:
Biological Psychiatry. 77:425-433
Background Circadian gene disruptions are associated with the development of psychiatric disorders, including addiction. However, the mechanisms by which circadian genes regulate reward remain poorly understood. Methods We used mice with a mutation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8d5dc6b76d43c5eb3d7912d436749a
https://doi.org/10.1016/j.biopsych.2014.07.030
https://doi.org/10.1016/j.biopsych.2014.07.030
Autor:
Rachael L. Neve, Allyson K. Friedman, Maria B. Carreira, Ming-Hu Han, Christopher W. Cowan, Daniel Guzman, Megumi Adachi, David W. Self, Lisa M. Monteggia
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(3)
Cocaine self-administration increases expression of GluA1 subunits in ventral tegmental area (VTA) dopamine neurons, which subsequently enhance the motivation for cocaine. This increase in GluA1 may be dependent on concomitant NMDA receptor (NMDAR) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3145fd1b66ec39b58ef7f51a6c8288d
https://pubmed.ncbi.nlm.nih.gov/29196318
https://pubmed.ncbi.nlm.nih.gov/29196318