Zobrazeno 1 - 10
of 3 546
pro vyhledávání: '"David A. Scott"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Porphyromonas gingivalis is a Gram-negative, anaerobic oral pathobiont, an etiological agent of periodontitis and the most commonly studied periodontal bacterium. Multiple low passage clinical isolates were sequenced, and their genomes compa
Externí odkaz:
https://doaj.org/article/b172ca62750043e58fadbbf701454325
Autor:
Alec McDonald, Carly Warden, Jinlian Tan, Kellianne M. Piell, Jill M. Steinbach-Rankins, Nandakumar Janakiraman, David A. Scott, Marsha P. Cole, Sudha Gudhimella
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 6982 (2024)
The acidic byproducts of bacteria in plaque around orthodontic brackets contribute to white spot lesion (WSL) formation. Nitric oxide (NO) has antibacterial properties, hindering biofilm formation and inhibiting the growth of oral microbes. Materials
Externí odkaz:
https://doaj.org/article/a3e720c1246d40b0867dccb084c29198
Autor:
Steven McGuigan, Daniel J. Marie, Liam J. O'Bryan, Francisco J. Flores, Lisbeth Evered, Brendan Silbert, David A. Scott
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionXenon exhibits significant neuroprotection against a wide range of neurological insults in animal models. However, clinical evidence that xenon improves outcomes in human studies of neurological injury remains elusive. Previous reviews of
Externí odkaz:
https://doaj.org/article/4adf785090e7498eb631c880dad611dc
Autor:
M. Fata Moradali, Shirin Ghods, Heike Bähre, Richard J. Lamont, David A. Scott, Roland Seifert
Publikováno v:
npj Biofilms and Microbiomes, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Microbial pathogens employ signaling systems through cyclic (di-) nucleotide monophosphates serving as second messengers to increase fitness during pathogenesis. However, signaling schemes via second messengers in Porphyromonas gingivalis, a
Externí odkaz:
https://doaj.org/article/80870980ac724abaa801f36ce71d85d2
Autor:
Tyler S. Beyett, Ciric To, David E. Heppner, Jaimin K. Rana, Anna M. Schmoker, Jaebong Jang, Dries J. H. De Clercq, Gabriel Gomez, David A. Scott, Nathanael S. Gray, Pasi A. Jänne, Michael J. Eck
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Acquired drug resistance is common during chemotherapy. Here, the authors describe the structural basis and molecular mechanism by which allosteric and clinically approved, ATP-competitive inhibitors of EGFR synergize to overcome resistance in lung c
Externí odkaz:
https://doaj.org/article/b71e888015d54f3e90272f29edf5c334
Autor:
Colin McGaw, Anthony J. Garrity, Gabrielle Z. Munoz, Jeffrey R. Haswell, Sejuti Sengupta, Elise Keston-Smith, Pratyusha Hunnewell, Alexa Ornstein, Mishti Bose, Quinton Wessells, Noah Jakimo, Paul Yan, Huaibin Zhang, Lauren E. Alfonse, Roy Ziblat, Jason M. Carte, Wei-Cheng Lu, Derek Cerchione, Brendan Hilbert, Shanmugapriya Sothiselvam, Winston X. Yan, David R. Cheng, David A. Scott, Tia DiTommaso, Shaorong Chong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Cas12i is a genome editing platform with compact size that fits in AAV vector with short 43-mer gRNA, absence of tracrRNA, ability to process pre-crRNA, and high specificity. Here the authors present an unbiased mutational scanning approach to engine
Externí odkaz:
https://doaj.org/article/b34236ad23cc4e1cb4a7c8a576cc399b
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 1959 (2022)
Cannabinoid receptor 2 (CB2) is of interest as a much-needed target for the treatment or prevention of several neurogenerative diseases. However, CB2 agonists, particularly phytocannabinoids, have been ascribed antimicrobial properties and are associ
Externí odkaz:
https://doaj.org/article/7aabfabe736d41699c494dccf369e0d7
Autor:
Lisa Elmén, Jaime E. Zlamal, David A. Scott, Ryan B. Lee, Daniel J. Chen, Alexandre R. Colas, Dmitry A. Rodionov, Scott N. Peterson
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Dietary emulsifiers are widely used in industrially processed foods, although the effects of these food additives on human gut microbiota are not well studied. Here, we investigated the effects of five different emulsifiers [glycerol monoacetate, gly
Externí odkaz:
https://doaj.org/article/4d5e4a177d3645f3b913542d1d786a90
Autor:
Vandana Sharma, Jamie Smolin, Jonamani Nayak, Julio E. Ayala, David A. Scott, Scott N. Peterson, Hudson H. Freeze
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3087-3098 (2018)
Summary: Mannose is an important monosaccharide for protein glycosylation in mammals but is an inefficient cellular energy source. Using a C57BL6/J mouse model of diet-induced obesity, we show that mannose supplementation of high-fat-diet-fed mice pr
Externí odkaz:
https://doaj.org/article/d13214b7c82c4304a328afe233aed6d7
Autor:
Zhen Gu, Shilpa Singh, Rajarshi G. Niyogi, Gwyneth J. Lamont, Huizhi Wang, Richard J. Lamont, David A. Scott
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Cannabis use is an emergent risk factor for periodontitis, a chronic bacterial-induced disease of the supporting structures of the teeth. However, the mechanisms by which marijuana exposure predisposes to periodontal tissue destruction have yet to be
Externí odkaz:
https://doaj.org/article/81f9b9992c8b449989b3e258a582d4b5