Zobrazeno 1 - 10
of 366
pro vyhledávání: '"David A. Scheinberg"'
Autor:
Matthias Miederer, Martina Benešová-Schäfer, Constantin Mamat, David Kästner, Marc Pretze, Enrico Michler, Claudia Brogsitter, Jörg Kotzerke, Klaus Kopka, David A. Scheinberg, Michael R. McDevitt
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 76 (2024)
The use of radionuclides for targeted endoradiotherapy is a rapidly growing field in oncology. In particular, the focus on the biological effects of different radiation qualities is an important factor in understanding and implementing new therapies.
Externí odkaz:
https://doaj.org/article/25291905b7a14e40b287668ad107995a
Autor:
Katsuyoshi Takata, Lauren C. Chong, Daisuke Ennishi, Tomohiro Aoki, Michael Yu Li, Avinash Thakur, Shannon Healy, Elena Viganò, Tao Dao, Daniel Kwon, Gerben Duns, Julie S. Nielsen, Susana Ben-Neriah, Ethan Tse, Stacy S. Hung, Merrill Boyle, Sung Soo Mun, Christopher M. Bourne, Bruce Woolcock, Adèle Telenius, Makoto Kishida, Shinya Rai, Allen W. Zhang, Ali Bashashati, Saeed Saberi, Gianluca D’Antonio, Brad H. Nelson, Sohrab P. Shah, Pamela A. Hoodless, Ari M. Melnick, Randy D. Gascoyne, Joseph M. Connors, David A. Scheinberg, Wendy Béguelin, David W. Scott, Christian Steidl
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
PRAME is a prominent member of the cancer testis antigen family of proteins, which triggers autologous T cell–mediated immune responses. Integrative genomic analysis in diffuse large B cell lymphoma (DLBCL) uncovered recurrent and highly focal dele
Externí odkaz:
https://doaj.org/article/1a16abd2d3774266828be223d0374b3a
Autor:
Sam Wong, Simone Alidori, Barbara P. Mello, Bryan Aristega Almeida, David Ulmert, Matthew B. Brendel, David A. Scheinberg, Michael R. McDevitt
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Cellulose nanocrystals (CNC) are linear organic nanomaterials derived from an abundant naturally occurring biopolymer resource. Strategic modification of the primary and secondary hydroxyl groups on the CNC introduces amine and iodine group
Externí odkaz:
https://doaj.org/article/3ada09b285da4525900a0ed8147bb509
Autor:
Tao Dao, Sung Soo Mun, Zaki Molvi, Tatyana Korontsvit, Martin G. Klatt, Abdul G. Khan, Elisabeth K. Nyakatura, Mary Ann Pohl, Thomas E. White, Paul J. Balderes, Ivo C. Lorenz, Richard J. O’Reilly, David A. Scheinberg
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
Phosphopeptides derived from dysregulated protein phosphorylation in cancer cells can be processed and presented by MHC class I and class II molecules and, therefore, represent an untapped class of tumor-specific antigens that could be used as widely
Externí odkaz:
https://doaj.org/article/ad5bf238d330474d91bbd79a36a433b8
Autor:
Tao Dao, Sungsoo Mun, Tatyana Korontsvit, Abdul G. Khan, Mary Ann Pohl, Thomas White, Martin G. Klatt, David Andrew, Ivo C. Lorenz, David A. Scheinberg
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
More effective treatments are needed for human papilloma virus (HPV)-induced cancers despite HPV virus vaccination. The oncogenic HPV protein targets are currently undruggable and intracellular and therefore there are no antibodies to these targets.
Externí odkaz:
https://doaj.org/article/80208262b1ca48dd97192f7f086e534b
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
The use of T cells reactive with intracellular tumor-associated or tumor-specific antigens has been a promising strategy for cancer immunotherapies in the past three decades, but the approach has been constrained by a limited understanding of the T c
Externí odkaz:
https://doaj.org/article/052f0fa6b26a4602a9686c88d42adb8a
Autor:
Angel Charles, Christopher M. Bourne, Tanya Korontsvit, Zita E. H. Aretz, Sung Soo Mun, Tao Dao, Martin G. Klatt, David A. Scheinberg
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Cyclin dependent kinase 4/6 inhibitors (CDK4/6i) lead to cell-cycle arrest but also trigger T cell-mediated immunity, which might be mediated by changes in human leukocyte antigen (HLA) ligands. We investigated the effects of CDK4/6i, abemaciclib and
Externí odkaz:
https://doaj.org/article/a3a63b8e735c4265b023dcb79db8e5ba
Autor:
Martin G. Klatt, Kyeara N. Mack, Yang Bai, Zita E. H. Aretz, Levy I. Nathan, Sung Soo Mun, Tao Dao, David A. Scheinberg
Publikováno v:
JCI Insight, Vol 5, Iss 19 (2020)
Identification of MHC class I–bound peptides by immunopurification of MHC complexes and subsequent analysis by mass spectrometry is crucial for understanding T cell immunology and immunotherapy. Investigation of the steps for the MHC ligand isolati
Externí odkaz:
https://doaj.org/article/142e655b29fc4295aa55ab44c17794e1
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Chimeric antigen receptor (CAR) – and T-cell receptor (TCR) – modified T-cells are rapidly emerging as a viable treatment option for cancer patients. While initial clinical trials for these CAR T cells showed response rates of over 90% in some ca
Externí odkaz:
https://doaj.org/article/312ffd5202004fc391742e1e46e4a7d2
Autor:
Peter G. Maslak, Tao Dao, Yvette Bernal, Suzanne M. Chanel, Rong Zhang, Mark Frattini, Todd Rosenblat, Joseph G. Jurcic, Renier J. Brentjens, Maria E. Arcila, Raajit Rampal, Jae H. Park, Dan Douer, Laura Katz, Nicholas Sarlis, Martin S. Tallman, David A. Scheinberg
Publikováno v:
Blood Advances, Vol 2, Iss 3, Pp 224-234 (2018)
Abstract: A National Cancer Institute consensus study on prioritization of cancer antigens ranked the Wilms tumor 1 (WT1) protein as the top immunotherapy target in cancer. We previously reported a pilot study of a multivalent WT1 peptide vaccine (ga
Externí odkaz:
https://doaj.org/article/e8c8ca07418543a4ba9a1d688ecc3f94