Zobrazeno 1 - 10
of 605
pro vyhledávání: '"David A. Savage"'
Autor:
Ho Fai Chan, Zhiming Cheng, Silvia Mendolia, Alfredo R. Paloyo, Massimiliano Tani, Damon Proulx, David A. Savage, Benno Torgler
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract During the COVID-19 pandemic, several governments tried to contain the spread of SARS-CoV-2, the virus that causes COVID-19, with lockdowns that prohibited leaving one’s residence unless carrying out a few essential services. We investigat
Externí odkaz:
https://doaj.org/article/a8fbf10165b84e5598201efc98c5379f
Autor:
Luis E. Valentin-Alvarado, Kathryn E. Appler, Valerie De Anda, Marie C. Schoelmerich, Jacob West-Roberts, Veronika Kivenson, Alexander Crits-Christoph, Lynn Ly, Rohan Sachdeva, Chris Greening, David F. Savage, Brett J. Baker, Jillian F. Banfield
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The roles of Asgard archaea in eukaryogenesis and marine biogeochemical cycles are well studied, yet their contributions in soil ecosystems remain unknown. Of particular interest are Asgard archaeal contributions to methane cycling in wetlan
Externí odkaz:
https://doaj.org/article/7d232f7c164e4cdda84944e08b4c39bb
Autor:
Ayman Hassan, Rachid Benlamri, Trina Diner, Keli Cristofaro, Lucas Dillistone, Hajar Khallouki, Mahvareh Ahghari, Shalyn Littlefield, Rabail Siddiqui, Russell MacDonald, David W Savage
Publikováno v:
JMIR Formative Research, Vol 8, p e54009 (2024)
BackgroundA coordinated care system helps provide timely access to treatment for suspected acute stroke. In Northwestern Ontario (NWO), Canada, communities are widespread with several hospitals offering various diagnostic equipment and services. Thus
Externí odkaz:
https://doaj.org/article/df0790b9d0374c1f8435a0ff67bda20b
Autor:
Lauren Ann Metskas, Davi Ortega, Luke M. Oltrogge, Cecilia Blikstad, Derik R. Lovejoy, Thomas G. Laughlin, David F. Savage, Grant J. Jensen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Many autotrophic bacteria rely on Rubisco for carbon dioxide fixation. Here the authors report the position, orientation, and structure of Rubisco within alpha-carboxysomes; showing how it polymerizes and can form a lattice inside this compartment.
Externí odkaz:
https://doaj.org/article/6cf92f36ffdc4b48aca60c160c65bcd5
Autor:
Robert Ohle, Sarah McIsaac, Madison Van Drusen, Aaron Regis, Owen Montpellier, Mackenzie Ludgate, Oluwadamilola Bodunde, David W. Savage, Krishan Yadav
Publikováno v:
Emergency Medicine International, Vol 2023 (2023)
Introduction. Acute aortic syndrome (AAS) is a rare clinical syndrome with a high mortality rate. The Canadian clinical practice guideline for the diagnosis of AAS was developed in order to reduce the frequency of misdiagnoses. As part of the guideli
Externí odkaz:
https://doaj.org/article/fb816ddede3541438fc5d3839b446d22
Autor:
Benjamin J. LaFrance, Caleb Cassidy-Amstutz, Robert J. Nichols, Luke M. Oltrogge, Eva Nogales, David F. Savage
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Bacterial nanocompartments, also known as encapsulins, are an emerging class of protein-based ‘organelles’ found in bacteria and archaea. Encapsulins are virus-like icosahedral particles comprising a ~ 25–50 nm shell surrounding a spec
Externí odkaz:
https://doaj.org/article/02ef4047d2ff45de8942231742dab155
Autor:
Arik Shams, Sean A. Higgins, Christof Fellmann, Thomas G. Laughlin, Benjamin L. Oakes, Rachel Lew, Shin Kim, Maria Lukarska, Madeline Arnold, Brett T. Staahl, Jennifer A. Doudna, David F. Savage
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Proteins evolve through the modular rearrangement of domains. Here the authors introduce MISER, a minimization by iterative size-exclusion and recombination method to make all possible deletions of a protein, uncovering functions for Cas9 domains inv
Externí odkaz:
https://doaj.org/article/f92b1a4bf0574fe9b95344d8bcec8e40
Autor:
Satish Patel, Afreen Haider, Anna Alvarez-Guaita, Guillaume Bidault, Julia Sarah El-Sayed Moustafa, Esther Guiu-Jurado, John A. Tadross, James Warner, James Harrison, Samuel Virtue, Fabio Scurria, Ilona Zvetkova, Matthias Blüher, Kerrin S. Small, Stephen O’Rahilly, David B. Savage
Publikováno v:
Molecular Metabolism, Vol 65, Iss , Pp 101589- (2022)
Objectives: Obesity in humans and mice is associated with elevated levels of two hormones responsive to cellular stress, namely GDF15 and FGF21. Over-expression of each of these is associated with weight loss and beneficial metabolic changes but wher
Externí odkaz:
https://doaj.org/article/86d575de029d49f1be5d61f2c525a70f
Autor:
David J. Savage
Publikováno v:
FASEB BioAdvances, Vol 3, Iss 6, Pp 449-455 (2021)
Abstract The COVID‐19 pandemic has been transformative for healthcare and medical education. Physician trainees and the education system that serves them adapted quickly so that trainees could finish the academic year on time and advance to the nex
Externí odkaz:
https://doaj.org/article/0070d658bd224113a84bbf3af20c0cb2
Autor:
Dionysios Grigoriadis, Ege Sackey, Katie Riches, Malou van Zanten, Glen Brice, Ruth England, Mike Mills, Sara E. Dobbins, Li Ling Lee, Steve Jeffery, Liang Dong, David B. Savage, Peter S. Mortimer, Vaughan Keeley, Alan Pittman, Kristiana Gordon, Pia Ostergaard
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Lipoedema is a chronic adipose tissue disorder mainly affecting women, causing excess subcutaneous fat deposition on the lower limbs with pain and tenderness. There is often a family history of lipoedema, suggesting a genetic origin, but the contribu
Externí odkaz:
https://doaj.org/article/690ab941e0c2484cbd480d1834ebbb70