Zobrazeno 1 - 10
of 55
pro vyhledávání: '"David A. Romney"'
Publikováno v:
The Journal of Politics. 84:2156-2171
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::768f69cf1244d6de222e8b8661bf82ce
https://doi.org/10.1086/719416
https://doi.org/10.1086/719416
Autor:
Joshua S. Alford, Nadia C. Abascal, Christopher R. Shugrue, Sean M. Colvin, David K. Romney, Scott J. Miller
Publikováno v:
ACS Central Science, Vol 2, Iss 10, Pp 733-739 (2016)
Externí odkaz:
https://doaj.org/article/4f58c1efba964f8caa33a69e9dce521a
Publikováno v:
ACS Catal
C–C bond-forming reactions often require nucleophilic carbon species rarely compatible with aqueous reaction media, thus restricting their appearance in biocatalysis. Here we report the use of nitroalkanes as a structurally versatile class of nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a2efe226bff78f2352783f688ba0ef
https://resolver.caltech.edu/CaltechAUTHORS:20190903-130240854
https://resolver.caltech.edu/CaltechAUTHORS:20190903-130240854
Autor:
Sean M. Colvin, Christopher R. Shugrue, Scott J. Miller, Nadia C. Abascal, David K. Romney, Joshua S. Alford
Publikováno v:
ACS Central Science, Vol 2, Iss 10, Pp 733-739 (2016)
ACS Central Science
ACS Central Science
A remarkable aspect of enzyme evolution is the portability of catalytic mechanisms for fundamentally different chemical reactions. For example, aspartyl proteases, which contain two active site carboxylic acid groups, catalyze the hydrolysis of amide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a297c654eb0f9d3e1614943546e98468
https://doi.org/10.1021/acscentsci.6b00237
https://doi.org/10.1021/acscentsci.6b00237
Autor:
Sabine Brinkmann-Chen, Javier Murciano-Calles, Frances H. Arnold, Andrew R. Buller, David K. Romney
Publikováno v:
Angewandte Chemie. 128:11749-11753
Naturally occurring enzyme homologs often display highly divergent activity with non-natural substrates. Exploiting this diversity with enzymes engineered for new or altered function, however, is laborious because the engineering must be replicated f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0372f5d80494e698260aacd8cf1da8fb
https://doi.org/10.1002/ange.201606242
https://doi.org/10.1002/ange.201606242
Publikováno v:
The Journal of organic chemistry. 83(14)
Chemical reactions in water underpin the very existence of life. But to synthetic chemists, water is usually considered an enemy, lurking in the shadows, waiting to reduce yields and destroy reproducibility. Indeed, chemists often take great pains to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7e10eec979caafe51e3f476f4c4019
https://pubmed.ncbi.nlm.nih.gov/30025465
https://pubmed.ncbi.nlm.nih.gov/30025465
Publikováno v:
Artificial Metalloenzymes and MetalloDNAzymes in Catalysis ISBN: 9783527804085
Artificial Metalloenzymes and MetalloDNAzymes in Catalysis
Artificial Metalloenzymes and MetalloDNAzymes in Catalysis
Directed evolution is a powerful algorithm for engineering proteins to have novel and useful properties. However, we do not yet fully understand the characteristics of an evolvable system. In this chapter, we present examples where directed evolution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc95a4efd23109dec635aa3e5b9a0121
https://doi.org/10.1002/9783527804085.ch5
https://doi.org/10.1002/9783527804085.ch5
Publikováno v:
Advanced Synthesis & Catalysis. 357:2301-2309
We report an approach to the asymmetric Baeyer-Villiger oxidation utilizing bioinformatics-inspired combinatorial screening for catalyst discovery. Scaled-up validation of our on-bead efforts with a circular dichroism-based assay of alcohols derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91856c05093bae62069880bf88c02011
https://doi.org/10.1002/adsc.201500230
https://doi.org/10.1002/adsc.201500230
Derivatives of the amino acid tryptophan (Trp) serve as precursors for the chemical and biological synthesis of complex molecules with a wide range of biological properties. Trp analogues are also valuable as building blocks for medicinal chemistry a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57097e945a91ca959eeb306197f4224f
https://resolver.caltech.edu/CaltechAUTHORS:20180820-085301341
https://resolver.caltech.edu/CaltechAUTHORS:20180820-085301341
Publikováno v:
Journal of the American Chemical Society. 139(30)
An enantioselective total synthesis of the norditerpenoid alkaloid nigelladine A is described. Strategically, the synthesis relies on a late-stage C–H oxidation of an advanced intermediate. While traditional chemical methods failed to deliver the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce94b5d3c9a6599306b3221cd101e7a2
https://pubmed.ncbi.nlm.nih.gov/28721734
https://pubmed.ncbi.nlm.nih.gov/28721734