Výsledky vyhledávání - "David A. Plotnik"

In vitro analysis of transport and metabolism of 4′-thiothymidine in human tumor cells

Autor: Franco Chi Tat Yip, David A. Plotnik, Jun Toyohara, Jeffrey L. Schwartz, Natacha Lou Comandante, Kenneth A. Krohn, Geoffrey Linn, Stephen Wu

Publikováno v: Nuclear medicine and biology

Introduction The use of thymidine (TdR) and thymidine analogs such as 3′-fluoro-3′-deoxythymidine (FLT) as positron emission tomography (PET)-based proliferation markers can provide information on tumor response to treatment. Studies on another T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61033630e374a2eeb418f7ba3084f49
https://doi.org/10.1016/j.nucmedbio.2014.12.005

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Levels of Human Equilibrative Nucleoside Transporter-1 are Higher in Proliferating Regions of A549 Tumor Cells Grown as Tumor Xenografts In Vivo

Autor: Camille Asher, Robert S. Miyaoka, Brian W. Johnson, Kenneth A. Krohn, Stephanie K. Chu, Gregory G. Garwin, Jeffrey L. Schwartz, David A. Plotnik, Tiffany Li

3'-Fluoro-3'-deoxythymidine (FLT) has been proposed for positron emission tomography (PET)-based identification of tumor chemosensitivity that is mediated by the human equilibrative nucleoside transporter-1 (ENT1). ENT1 facilitates transport of FLT i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b30160101e286f3737466fd68098e6
https://europepmc.org/articles/PMC3478396/

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Increased age of transformed mouse neural progenitor/stem cells recapitulates age-dependent clinical features of human glioma malignancy

Autor: Jeffrey L. Schwartz, Elizabeth A. Stoll, John R. Silber, Philip J. Horner, Yoshito Kosai, Richard P. Beyer, Andrei M. Mikheev, Jason K. Rockhill, Rohan Ramakrishna, Svetlana A. Mikheeva, Robert C. Rostomily, David A. Plotnik, Donald E. Born

Publikováno v: Aging (Albany NY)

Summary Increasing age is the most robust predictor of greater malignancy and treatment resistance in human gliomas. However, the adverse association of clinical course with aging is rarely considered in animal glioma models, impeding delineation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e273e119ce98c8dbc84e22e2ee79b4
https://pubmed.ncbi.nlm.nih.gov/23257545

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The effects of 5-fluoruracil treatment on 3'-fluoro-3'-deoxythymidine (FLT) transport and metabolism in proliferating and non-proliferating cultures of human tumor cells

Autor: David A. Plotnik, Lena McLaughlin, Jeffrey L. Schwartz, Kenneth A. Krohn

Publikováno v: Nuclear medicine and biology. 39(7)

3′-Fluoro-3′-deoxythymidine (FLT) positron emission tomography (PET) has been proposed for imaging thymidylate synthase (TS) inhibition. Agents that target TS and shut down de novo synthesis of thymidine monophosphate increase the uptake and rete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4328fce35befebf1ff99c1659187fb
https://pubmed.ncbi.nlm.nih.gov/22560972

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The Role of Nucleoside/Nucleotide Transport and Metabolism in the Uptake and Retention of 3’-Fluoro-3’-Deoxythymidine (FLT) in Human B-Lymphoblast Cells

Autor: Jenny Chan, Jeffrey L. Schwartz, David A. Plotnik, Joshua N. Redmayne-Titley, Lena McLaughlin

Introduction Recent studies in the human adenocarcinoma cell line A549 have identified cell growth-dependent equilibrative nucleoside transporter-1 (hENT1) as a modifier of 3′-fluoro-3′-deoxythymidine (FLT) uptake and retention. In the present st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66e651db132e71956c15f66dc53b1ac
https://europepmc.org/articles/PMC3190124/

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Tp53 codon-72 polymorphisms identify different radiation sensitivities to g2-chromosome breakage in human lymphoblast cells

Autor: Jeffrey L. Schwartz, Debra L. Friedman, Maximillian Racelis, Tiffany Li, David A. Plotnik, H. Joachim Deeg, Jana Slovic

Publikováno v: Environmental and molecular mutagenesis. 52(1)

Both the G2 chromosomal radiosensitivity assay and allelic differences in TP53 codon-72 have been associated with cancer predisposition. The relationship between the two endpoints was determined in 56 human EBV-transformed lymphoblastoid cell lines.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efddfed32ba7ec39eb623991bdd5cf86
https://pubmed.ncbi.nlm.nih.gov/21038427

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Different Modes of Transport for 3H-Thymidine, 3H-FLT, and 3H-FMAU in Proliferating and Nonproliferating Human Tumor Cells

Autor: Jeffrey L. Schwartz, Jashvant D. Unadkat, Lindsay E. Emerick, David A. Plotnik, Kenneth A. Krohn

1464 Objectives Donepezil is an acethylcholine esterase inhibitor and one of the major therapeutic drugs for Alzheimer’s decease (AD). Although it is widely used in AD patients, the pharmacokinetics of Donepezil remains unproven in vivo. We aimed t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c1b4ece3bb5dda6c362cbe4a6452a8
https://europepmc.org/articles/PMC3368522/

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