Zobrazeno 1 - 10
of 526
pro vyhledávání: '"David A. Pan"'
Autor:
Seung Hyuk T. Lee, Kristina M. Garske, Uma Thanigai Arasu, Asha Kar, Zong Miao, Marcus Alvarez, Amogha Koka, Nicholas Darci-Maher, Jihane N. Benhammou, David Z. Pan, Tiit Örd, Dorota Kaminska, Ville Männistö, Sini Heinonen, Martin Wabitsch, Markku Laakso, Vatche G. Agopian, Joseph R. Pisegna, Kirsi H. Pietiläinen, Jussi Pihlajamäki, Minna U. Kaikkonen, Päivi Pajukanta
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105232- (2024)
Summary: Background: Abdominal obesity increases the risk for non-alcoholic fatty liver disease (NAFLD), now known as metabolic dysfunction-associated steatotic liver disease (MASLD). Methods: To elucidate the directional cell-type level biological m
Externí odkaz:
https://doaj.org/article/a9ca2e74a8164304bf81b6dd03723f19
Autor:
David A. Pan, Michelle K. Mater, Annette P. Thelen, Jeffrey M. Peters, Frank J. Gonzalez, Donald B. Jump
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 5, Pp 742-751 (2000)
The glycolytic enzyme, L-pyruvate kinase (L-PK), plays an important role in hepatic glucose metabolism. Insulin and glucose induce L-PK gene expression, while glucagon and polyunsaturated fatty acids (PUFA) inhibit L-PK gene expression. We have been
Externí odkaz:
https://doaj.org/article/1a16505d17984b7b8035535958359176
Publikováno v:
APL Machine Learning, Vol 2, Iss 1, Pp 016106-016106-13 (2024)
Photonic computing shows promise for transformative advancements in machine learning (ML) acceleration, offering ultrafast speed, massive parallelism, and high energy efficiency. However, current photonic tensor core (PTC) designs based on standard o
Externí odkaz:
https://doaj.org/article/162ae7ca24244551b8f7843fe705b062
Autor:
Kristina M. Garske, Asha Kar, Caroline Comenho, Brunilda Balliu, David Z. Pan, Yash V. Bhagat, Gregory Rosenberg, Amogha Koka, Sankha Subhra Das, Zong Miao, Janet S. Sinsheimer, Jaakko Kaprio, Kirsi H. Pietiläinen, Päivi Pajukanta
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Obesity-induced adipose tissue dysfunction can cause low-grade inflammation and downstream obesity comorbidities. Although preadipocytes may contribute to this pro-inflammatory environment, the underlying mechanisms are unclear. We used huma
Externí odkaz:
https://doaj.org/article/3055f5bb90004824b10bd459d9c63909
Autor:
David Z. Pan, Pamela M. Odorizzi, Andre Schoenichen, Mazin Abdelghany, Shuguang Chen, Anu Osinusi, Scott D. Patterson, Bryan Downie, Kavita Juneja, Jeffrey J. Wallin
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-6 (2023)
Pan et al. determine the impact of the antiviral remdesivir (RDV) on biomarkers associated with clinical outcomes, within a randomized, double-blind, placebo-controlled phase 3 study (PINETREE). They demonstrate that RDV-treated patients have an acce
Externí odkaz:
https://doaj.org/article/8ae67f1cda5e4070bf72742899d454ad
Autor:
Kristina M. Garske, Caroline Comenho, David Z. Pan, Marcus Alvarez, Karen Mohlke, Markku Laakso, Kirsi H. Pietiläinen, Päivi Pajukanta
Publikováno v:
Epigenetics, Vol 17, Iss 13, Pp 1849-1862 (2022)
Obesity perturbs central functions of human adipose tissue, centred on differentiation of preadipocytes to adipocytes, i.e., adipogenesis. The large environmental component of obesity makes it important to elucidate epigenetic regulatory factors impa
Externí odkaz:
https://doaj.org/article/8b05b59ad3c34da58b79e4dfb81439c3
Autor:
Nicholas Darci-Maher, Marcus Alvarez, Uma Thanigai Arasu, Ilakya Selvarajan, Seung Hyuk T. Lee, David Z. Pan, Zong Miao, Sankha Subhra Das, Dorota Kaminska, Tiit Örd, Jihane N. Benhammou, Martin Wabitsch, Joseph R. Pisegna, Ville Männistö, Kirsi H. Pietiläinen, Markku Laakso, Janet S. Sinsheimer, Minna U. Kaikkonen, Jussi Pihlajamäki, Päivi Pajukanta
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104620- (2023)
Summary: Background: Non-alcoholic fatty liver disease (NAFLD) is a fast-growing, underdiagnosed, epidemic. We hypothesise that obesity-related inflammation compromises adipose tissue functions, preventing efficient fat storage, and thus driving ecto
Externí odkaz:
https://doaj.org/article/d790980f12064df98a63142b4ca4e5bb
Akademický článek
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Akademický článek
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Autor:
Mingtao Zhan, Yongpan Liu, Xiyuan Tang, David Z. Pan, Keren Zhu, Jaydeep P. Kulkarni, Nan Sun, Meizhi Wang, Xiangxing Yang, Nanshu Lu
Publikováno v:
CICC
AI edge devices require local intelligence for the concerns of latency and privacy. Given the accuracy and energy constraints, low-power convolutional neural networks (CNNs) are gaining popularity. To alleviate the high memory access energy and compu