Zobrazeno 1 - 10
of 17
pro vyhledávání: '"David A. Litvak"'
Publikováno v:
Case Reports in Oncology, Vol 5, Iss 3, Pp 601-607 (2012)
Background: Hypersplenism due to chemotherapy-related liver injury has been associated with severe thrombocytopenia that may preclude continuation of systemic therapy for cancer patients. Patients treated for metastatic colorectal cancer (mCRC) are a
Externí odkaz:
https://doaj.org/article/2cc551c95b6c4199ab158622cf8a3b99
Publikováno v:
Journal of the American College of Surgeons. 198:27-35
Standard prognostic factors, including precise staging of the regional lymph nodes, cannot accurately determine which early-stage melanomas will metastasize. The immune response to a 90-kd tumor-associated antigen correlates with occult nodal disease
Publikováno v:
JNCI Journal of the National Cancer Institute. 93:347-357
Inherent or acquired drug resistance, which frequently characterizes cancer cells, is caused by multiple mechanisms, including dysfunctional metabolism of the lipid second messenger ceramide. Ceramide, the basic structural unit of the sphingolipids,
Publikováno v:
Journal of Gastrointestinal Surgery. 3:618-624
Novel chemotherapeutic agents are needed to treat gastric cancer for which the prognosis remains dismal. The antitumor alkaloid camptothecin (CPT) may be useful in the treatment of certain solid tumors; however, its effects on gastric cancer are larg
Autor:
Richard A. Falcone, David A. Litvak, Brad W. Warner, Christopher J. Kemp, Cathy E. Shin, B. Mark Evers, Christopher R. Erwin
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 277:G717-G724
Adaptation following small bowel resection (SBR) signals enterocyte proliferation and apoptosis. Because p53-induced p21waf1/cip1may be important for apoptosis in many cells, we hypothesized that these genes are required for increased enterocyte apop
Autor:
Courtney M. Townsend, Kevin O. Hwang, B. Mark Evers, Mimi Kim, Harry T. Papaconstantinou, David A. Litvak
Publikováno v:
Surgery. 126:223-230
Background: The prognosis for gastric cancer remains dismal; novel agents that target specific molecular pathways are needed as adjuvant therapy. Camptothecin (CPT), an inhibitor of topoisomerase I, is effective in the treatment of certain solid tumo
Publikováno v:
Journal of Gastrointestinal Surgery. 3:432-440
Combination therapy with enterotrophic agents may be useful in patients with the short bowel syndrome. The gut hormones neurotensin (NT) and glucagon-like peptide 2 (GLP-2) are potent enterotrophic factors when administered alone; however, their comb
Autor:
Iseki H, Ambikaipakan Balasubramaniam, Evers Bm, David A. Litvak, Courtney M. Townsend, Iwase K, Greeley Gh, Mark R. Hellmich
Publikováno v:
Digestive Diseases and Sciences. 44:643-648
Effective clinical therapy to augment intestinal absorption of water and electrolytes does not exist; the gut hormone, peptide YY (PYY), is a potent proabsorptive agent in animal models. The purpose of our study was to evaluate the effects of two nov
Autor:
Courtney M. Townsend, Mark R. Hellmich, B. Mark Evers, Tien C. Ko, David A. Litvak, Kevin O. Hwang
Publikováno v:
Surgery. 124:161-170
Background: Intestinal mucosal turnover is a process of proliferation, differentiation, and apoptosis; the mechanisms remain largely undefined. The purpose of our study was to (1) assess the relationship between apoptosis and enterocyte differentiati
Autor:
David A. Litvak, Rajeev Arora
Publikováno v:
Archives of surgery (Chicago, Ill. : 1960). 141(10)
Hypothesis Elderly breast cancer patients are underdiagnosed and undertreated in a community hospital setting. Design Retrospective study of tumor registry patients. Setting Community hospital. Patients A total of 354 breast cancer patients aged 70 y