Zobrazeno 1 - 10
of 46
pro vyhledávání: '"David A. Link"'
Autor:
Donia E. Hafez, Mariam Dubiel, Gabriella La Spada, Marco Catto, David Reiner-Link, Yu-Ting Syu, Mohammad Abdel-Halim, Tsong-Long Hwang, Holger Stark, Ashraf H. Abadi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Neurodegenerative diseases such as Alzheimer’s disease (AD) are multifactorial with several different pathologic mechanisms. Therefore, it is assumed that multitargeted-directed ligands (MTDLs) which interact with different biological targets relev
Externí odkaz:
https://doaj.org/article/524cab4f650e41a28fe24ba5d6089fe3
Autor:
Justyna Godyń, Paula Zaręba, Dorota Stary, Maria Kaleta, Kamil J. Kuder, Gniewomir Latacz, Szczepan Mogilski, David Reiner-Link, Annika Frank, Agata Doroz-Płonka, Agnieszka Olejarz-Maciej, Sylwia Sudoł-Tałaj, Tobias Nolte, Jadwiga Handzlik, Holger Stark, Anna Więckowska, Barbara Malawska, Katarzyna Kieć-Kononowicz, Dorota Łażewska, Marek Bajda
Publikováno v:
Molecules, Vol 28, Iss 1, p 238 (2022)
The multitarget-directed ligands demonstrating affinity to histamine H3 receptor and additional cholinesterase inhibitory potency represent a promising strategy for research into the effective treatment of Alzheimer’s disease. In this study, a nove
Externí odkaz:
https://doaj.org/article/2481fe283dea45f89bc7efb49683033f
Autor:
Dorota Łażewska, Agata Siwek, Agnieszka Olejarz-Maciej, Agata Doroz-Płonka, Anna Wiktorowska-Owczarek, Marta Jóźwiak-Bębenista, David Reiner-Link, Annika Frank, Wioletta Sromek-Trzaskowska, Ewelina Honkisz-Orzechowska, Ewelina Królicka, Holger Stark, Marek Wieczorek, Waldemar Wagner, Katarzyna Kieć-Kononowicz, Anna Stasiak
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2187 (2022)
The clinical symptoms of Parkinson’s disease (PD) appear when dopamine (DA) concentrations in the striatum drops to around 20%. Simultaneous inhibitory effects on histamine H3 receptor (H3R) and MAO B can increase DA levels in the brain. A series o
Externí odkaz:
https://doaj.org/article/9d182e4dcb5d4290bc05ad6a476c576a
Autor:
Dorota Łażewska, Paula Zaręba, Justyna Godyń, Agata Doroz-Płonka, Annika Frank, David Reiner-Link, Marek Bajda, Dorota Stary, Szczepan Mogilski, Agnieszka Olejarz-Maciej, Maria Kaleta, Holger Stark, Barbara Malawska, Katarzyna Kieć-Kononowicz
Publikováno v:
Molecules, Vol 26, Iss 12, p 3580 (2021)
Neurodegenerative diseases, e.g., Alzheimer’s disease (AD), are a key health problem in the aging population. The lack of effective therapy and diagnostics does not help to improve this situation. It is thought that ligands influencing multiple but
Externí odkaz:
https://doaj.org/article/d9e7c3fbce1d4dee984dbfe75cd18352
Publikováno v:
Ideen- und Innovationsmanagement.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bfcc9d40bec0b10790cf84a8e5e5768
https://doi.org/10.37307/j.2198-3151.2023.01.07
https://doi.org/10.37307/j.2198-3151.2023.01.07
Autor:
Kamil J. Kuder, Magdalena Kotańska, Katarzyna Szczepańska, Kamil Mika, David Reiner-Link, Holger Stark, Katarzyna Kieć-Kononowicz
Publikováno v:
Molecules, Vol 26, Iss 8, p 2300 (2021)
In an attempt to find new dual acting histamine H3 receptor (H3R) ligands, we designed a series of compounds, structurally based on previously described in our group, a highly active and selective human histamine H3 receptor (hH3R) ligand KSK63. As a
Externí odkaz:
https://doaj.org/article/f6dc552355194124acf7001217757fb2
Autor:
David Reiner-Link, Alexander S. Hauser
Publikováno v:
BIOspektrum. 28:140-143
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a62b812a1d9ab5f00c64b944db970434
https://doi.org/10.1007/s12268-022-1721-x
https://doi.org/10.1007/s12268-022-1721-x
Autor:
Cecília M S Q, Aranha, David, Reiner-Link, Luisa R, Leitzbach, Flavia B, Lopes, Holger, Stark, João Paulo S, Fernandes
Publikováno v:
Bioorganicmedicinal chemistry. 78
Multitargeting ligands on enzymes and receptors may generate a profile for a potential treatment of cognitive impairment. Considering this, a set of 21 substituted aryl-alkyl-piperazines were designed, prepared and tested for their binding affinities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::035cdeac91f4fa0ca3ac42e50d8abf47
https://pubmed.ncbi.nlm.nih.gov/36542960
https://pubmed.ncbi.nlm.nih.gov/36542960
Autor:
Olga A, Sergeeva, Karolina, Mazur, David, Reiner-Link, Kiril, Lutsenko, Helmut L, Haas, Mercedes, Alfonso-Prieto, Holger, Stark
Publikováno v:
Neuropharmacology. 215
Histaminergic (HA) neurons are located in the tuberomamillary nucleus (TMN) of the posterior hypothalamus, from where they project throughout the whole brain to control wakefulness. We examined the effects of N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5764d5da0fa00ebe3f68993f0fc5a89e
https://pubmed.ncbi.nlm.nih.gov/35750238
https://pubmed.ncbi.nlm.nih.gov/35750238
Autor:
Olga A. Sergeeva, Karolina Mazur, David Reiner-Link, Kiril Lutsenko, Helmut L. Haas, Mercedes Alfonso-Prieto, Holger Stark
Publikováno v:
Neuropharmacology 215, 109167 (2022). doi:10.1016/j.neuropharm.2022.109167
Histaminergic (HA) neurons are located in the tuberomamillary nucleus (TMN) of the posterior hypothalamus, from where they project throughout the whole brain to control wakefulness. We examined the effects of Nα-oleoylhistamine (OLHA), a non-enzymat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b12a34dc75cf4618bf0f3e055ef6fb
https://juser.fz-juelich.de/record/908294
https://juser.fz-juelich.de/record/908294
