Zobrazeno 1 - 10
of 29
pro vyhledávání: '"David A. Kocisko"'
Publikováno v:
Journal of Wildlife Diseases. 48:530-533
We compared prion infection rates among mule deer (Odocoileus hemionus) receiving pentosan polysulfate, tannic acid, tetracycline HCl, or no treatment 14 days before to 14 days after (dpi) oral inoculation with tonsil tissue homogenate. All deer were
Autor:
Emily A. Olsen, David A. Kocisko, Kil Sun Lee, Kevin M. Arnold, Nadine Bertholet, Jean-Marc Juteau, Byron Caughey, Andrew Vaillant, Richard E. Race
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:1034-1044
Although transmissible spongiform encephalopathies (TSEs) are incurable, a key therapeutic approach is prevention of conversion of the normal, protease-sensitive form of prion protein (PrP-sen) to the disease-specific protease-resistant form of prion
Publikováno v:
Animal, Dairy, and Veterinary Science Faculty Publications
In vitro inhibitors of the accumulation of abnormal (protease-resistant) prion protein (PrP-res) can sometimes prolong the lives of scrapie-infected rodents. Here, transgenic mice were used to test the in vivo anti-scrapie activities of new PrP-res i
Autor:
David A. Kocisko, Douglas S. Walsh, Chirapa Eamsila, Thomas G. Brewer, Bruce G. Charles, Michael D. Edstein
Publikováno v:
British Journal of Clinical Pharmacology. 52:663-670
Aims To describe the population pharmacokinetics of tafenoquine in healthy volunteers after receiving tafenoquine for malaria prophylaxis. Methods The population consisted of 135 male Thai soldiers (mean age 28.9 years; weight 60.3 kg). All soldiers
Autor:
David A. Kocisko, Grant Y. Roper, John D. Morrey, Richard E. Race, Winslow S. Caughey, Byron Caughey
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:759-761
Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but on
Autor:
Byron Caughey, David A. Kocisko
Publikováno v:
Journal of Virology. 80:1044-1046
In view of the effectiveness of antimalaria drugs inhibiting abnormal protease-resistant prion protein (PrP-res) formation in scrapie agent-infected cells, we tested other antimalarial compounds for similar activity. Mefloquine (MF), a quinoline anti
Publikováno v:
Chemistry & Biology. 2(12):807-817
Introduction : Scrapie infection instigates the in vivo conversion of normal, protease-sensitive prion protein (PrPc) into a protease-resistant form (PrP Sc ) by an unknown mechanism. In vitro studies have indicated that PrP Sc can induce this conver
Autor:
David A. Kocisko, Byron Caughey, Peter T. Lansbury, Suzette A. Priola, Gregory J. Raymond, Bruce Chesebro
Publikováno v:
Proceedings of the National Academy of Sciences. 92:3923-3927
Scrapie is a transmissible neurodegenerative disease that appears to result from an accumulation in the brain of an abnormal protease-resistant isoform of prion protein (PrP) called PrPsc. Conversion of the normal, protease-sensitive form of PrP (PrP
Autor:
Gregory J. Raymond, Bruce Chesebro, Suzette A. Priola, Byron Caughey, David A. Kocisko, Peter T. Lansbury, Jon H. Come
Publikováno v:
Nature. 370:471-474
THE infectious agent (or 'prion') of the transmissible spongiform encephalopathies (TSEs) such as scrapie resembles a virus in that it replicates in vivo and has distinct strains1, but it was postulated long ago to contain only protein2,3. More recen
Autor:
Lynne D. Raymond, Suzette A. Priola, David A. Kocisko, Byron Caughey, Winslow S. Caughey, Anne Ward
Publikováno v:
Antimicrobial agents and chemotherapy. 51(11)
Cyclic tetrapyrroles are among the most potent compounds with activity against transmissible spongiform encephalopathies (TSEs; or prion diseases). Here the effects of differential sulfonation and metal binding to cyclic tetrapyrroles were investigat