Zobrazeno 1 - 10
of 35
pro vyhledávání: '"David A. Kircher"'
Autor:
Joseph H. Cho, James P. Robinson, Rowan A. Arave, William J. Burnett, David A. Kircher, Guo Chen, Michael A. Davies, Allie H. Grossmann, Matthew W. VanBrocklin, Martin McMahon, Sheri L. Holmen
Publikováno v:
Cell Reports, Vol 13, Iss 5, Pp 898-905 (2015)
Metastases are the major cause of melanoma-related mortality. Previous studies implicating aberrant AKT signaling in human melanoma metastases led us to evaluate the effect of activated AKT1 expression in non-metastatic BRAFV600E/Cdkn2aNull mouse mel
Externí odkaz:
https://doaj.org/article/4e2c49c5716c454581ddfb0df503505a
Autor:
Sheri L. Holmen, Matthew W. VanBrocklin, Michelle C. Mendoza, Michael A. Davies, Martin McMahon, Kenneth M. Boucher, Keith L. Duffy, Allie H. Grossmann, Sean C. Strain, Christopher M. Stehn, Stephanie N. Angel, Grant M. Fischer, Gennie L. Parkman, Mark R. Silvis, Kirby A. Trombetti, David A. Kircher
Supplementary Figure 6. Expression of AKT1E17K promotes the dysregulation of integrins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9454b5a10eb9a2a4fe403f92b1302221
https://doi.org/10.1158/1541-7786.22514937
https://doi.org/10.1158/1541-7786.22514937
Autor:
Michael A. Davies, Michael T. Tetzlaff, Sheri L. Holmen, Jianjun Zhang, Joseph R. Marszalek, Ralph J. DeBerardinis, Alexander J. Lazar, Nagireddy Putluri, P. Andrew Futreal, Jennifer A. Wargo, Jason T. Huse, Patrick Hwu, Y. N. Vashisht Gopal, Jeffrey E. Gershenwald, Isabella C. Glitza, Hussein A. Tawbi, Sherise D. Ferguson, Wanleng Deng, Barbara Knighton, Courtney W. Hudgens, Arun Sreekumar, Chandrashekar R. Ambati, Anuj Srivastava, Chendong Yang, Fernando C. L. Carapeto, Mariana P. de Macedo, Alexandre Reuben, Aron Y. Joon, Lauren E. Haydu, Jennifer L. McQuade, Won-Chul Lee, David A. Kircher, Ali Jalali, Grant M. Fischer
Table S1: Clinical Characteristics of Melanoma Brain Metastases, Extracranial Metastases, and Primary Tumors. Tab 1. Clinical data for the MBMs and ECMs from melanoma patients utilized in this manuscript. Tab 2. Clinical data for primary melanomas fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148f98af1114c021ea7fd51f54fd55bd
https://doi.org/10.1158/2159-8290.22535959
https://doi.org/10.1158/2159-8290.22535959
Autor:
Michael A. Davies, Michael T. Tetzlaff, Sheri L. Holmen, Jianjun Zhang, Joseph R. Marszalek, Ralph J. DeBerardinis, Alexander J. Lazar, Nagireddy Putluri, P. Andrew Futreal, Jennifer A. Wargo, Jason T. Huse, Patrick Hwu, Y. N. Vashisht Gopal, Jeffrey E. Gershenwald, Isabella C. Glitza, Hussein A. Tawbi, Sherise D. Ferguson, Wanleng Deng, Barbara Knighton, Courtney W. Hudgens, Arun Sreekumar, Chandrashekar R. Ambati, Anuj Srivastava, Chendong Yang, Fernando C. L. Carapeto, Mariana P. de Macedo, Alexandre Reuben, Aron Y. Joon, Lauren E. Haydu, Jennifer L. McQuade, Won-Chul Lee, David A. Kircher, Ali Jalali, Grant M. Fischer
There is a critical need to improve our understanding of the pathogenesis of melanoma brain metastases (MBM). Thus, we performed RNA sequencing on 88 resected MBMs and 42 patient-matched extracranial metastases; tumors with sufficient tissue also und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45fe37c67c89f90e93ffd1ae70dd8269
https://doi.org/10.1158/2159-8290.c.6547993.v1
https://doi.org/10.1158/2159-8290.c.6547993.v1
Autor:
Sheri L. Holmen, Matthew W. VanBrocklin, Michelle C. Mendoza, Michael A. Davies, Martin McMahon, Kenneth M. Boucher, Keith L. Duffy, Allie H. Grossmann, Sean C. Strain, Christopher M. Stehn, Stephanie N. Angel, Grant M. Fischer, Gennie L. Parkman, Mark R. Silvis, Kirby A. Trombetti, David A. Kircher
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032b32ea8a6305ee92a068d90d7dffaa
https://doi.org/10.1158/1541-7786.22514931
https://doi.org/10.1158/1541-7786.22514931
Autor:
Michael A. Davies, Michael T. Tetzlaff, Sheri L. Holmen, Jianjun Zhang, Joseph R. Marszalek, Ralph J. DeBerardinis, Alexander J. Lazar, Nagireddy Putluri, P. Andrew Futreal, Jennifer A. Wargo, Jason T. Huse, Patrick Hwu, Y. N. Vashisht Gopal, Jeffrey E. Gershenwald, Isabella C. Glitza, Hussein A. Tawbi, Sherise D. Ferguson, Wanleng Deng, Barbara Knighton, Courtney W. Hudgens, Arun Sreekumar, Chandrashekar R. Ambati, Anuj Srivastava, Chendong Yang, Fernando C. L. Carapeto, Mariana P. de Macedo, Alexandre Reuben, Aron Y. Joon, Lauren E. Haydu, Jennifer L. McQuade, Won-Chul Lee, David A. Kircher, Ali Jalali, Grant M. Fischer
Supplemental Methods; Supplemental References
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6743e0d761222fba166485d60f9ef92c
https://doi.org/10.1158/2159-8290.22535962
https://doi.org/10.1158/2159-8290.22535962
Autor:
Allie H. Grossmann, Sheri L. Holmen, Dean Y. Li, Shannon J. Odelberg, Andrea Bild, David A. Kircher, Coulson P. Rich, Donghan Shin, Tara Mleynek, Roger K. Wolff, Lise K. Sorensen, Jingfu Peng, Aaron Rogers, Lehi Acosta-Alvarez, Samuel W. Brady, Jae Hyuk Yoo
Figure S4. Primary tumor incidence, growth, survival and metastasis in Ptenf/f vs. Arf6Q67L mice. (a) Increased tumor incidence (% = # of mice that developed a tumor / # TVA positive, injected mice) in Ptenf/f vs. Arf6Q67L cohorts. Fisher's exact tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9def0b48b2cc83022bfecdb8248f0a63
https://doi.org/10.1158/0008-5472.22420623
https://doi.org/10.1158/0008-5472.22420623
Autor:
Allie H. Grossmann, Sheri L. Holmen, Dean Y. Li, Shannon J. Odelberg, Andrea Bild, David A. Kircher, Coulson P. Rich, Donghan Shin, Tara Mleynek, Roger K. Wolff, Lise K. Sorensen, Jingfu Peng, Aaron Rogers, Lehi Acosta-Alvarez, Samuel W. Brady, Jae Hyuk Yoo
Melanoma has an unusual capacity to spread in early-stage disease, prompting aggressive clinical intervention in very thin primary tumors. Despite these proactive efforts, patients with low-risk, low-stage disease can still develop metastasis, indica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bfbd622d715707efdee9a96edeca39d
https://doi.org/10.1158/0008-5472.c.6510696
https://doi.org/10.1158/0008-5472.c.6510696
Autor:
Allie H. Grossmann, Sheri L. Holmen, Dean Y. Li, Shannon J. Odelberg, Andrea Bild, David A. Kircher, Coulson P. Rich, Donghan Shin, Tara Mleynek, Roger K. Wolff, Lise K. Sorensen, Jingfu Peng, Aaron Rogers, Lehi Acosta-Alvarez, Samuel W. Brady, Jae Hyuk Yoo
Table S1: ARF6 pathways and related genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3cad3eebeb5fc43555cf8b0b5bcb1b
https://doi.org/10.1158/0008-5472.22420611
https://doi.org/10.1158/0008-5472.22420611
Autor:
Gennie L. Parkman, Tursun Turapov, David A. Kircher, William J. Burnett, Christopher M. Stehn, Kayla O’Toole, Ryan Flaherty, Riley C. Elmer, Katie M. Culver, Mona Foth, Robert H. I. Andtbacka, David H. Lum, Robert Judson-Torres, Matthew W. VanBrocklin, Sheri L. Holmen, Martin McMahon
Aberrant activation of the PI3K-AKT pathway is common in melanoma but efforts to drug this pathway have proven largely ineffective in patients. In this study, we observed that pharmacological inhibition of AKT was ineffective whereas genetic silencin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1c4e543a02c06128ce930fbb3f826ad
https://doi.org/10.1101/2022.08.15.504039
https://doi.org/10.1101/2022.08.15.504039