Zobrazeno 1 - 10
of 20
pro vyhledávání: '"David A. Kau"'
Autor:
Robert Ford, Mario Bouchard, Andrew Whiting, Vivian Miao, Paul Brian, Richard H. Baltz, Marie-Francois Coëffet-Le Gal, Steve Martin, Julia Penn, Trevor Gibson, David A. Kau, Kien T. Nguyen, Jonathan Steele, Stephen K. Wrigley
Publikováno v:
Chemistry & Biology. 13:269-276
SummaryDaptomycin is a lipopeptide antibiotic produced by a nonribosomal peptide synthetase (NRPS) in Streptomyces roseosporus. The holoenzyme is composed of three subunits, encoded by the dptA, dptBC, and dptD genes, each responsible for incorporati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5959da5dd832b37b8f00bbc3dbb6fe
https://doi.org/10.1016/j.chembiol.2005.12.012
https://doi.org/10.1016/j.chembiol.2005.12.012
Autor:
Jay Chandra, Miguel A. Armengol de la Hoz, Gwendolyn Lee, Alexandria Lee, Patrick Thoral, Paul Elbers, Hyung-Chul Lee, John S. Munger, Leo Anthony Celi, David A. Kaufman
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-10 (2022)
Abstract Purpose Sepsis is a leading cause of morbidity and mortality worldwide and is characterized by vascular leak. Treatment for sepsis, specifically intravenous fluids, may worsen deterioration in the context of vascular leak. We therefore sough
Externí odkaz:
https://doaj.org/article/0cd522bcd3e34d1da13c44482afd79f1
Autor:
Stephen K. Wrigley, R. N. Manohar, L. Pairet, Steve Martin, M. I. Chicarelli-Robinson, J. M. Moloney, E. R. Olson, C. V. Byrne, S. J. Trew, Donald Hupe, Judith A. K. Howard, P. Shanu-Wilson, Martin A. Hayes, Elizabeth M. H. Wellington, J. Sohal, David A. Kau
Publikováno v:
The Journal of Antibiotics. 53:1-11
A series of halogenated pyrrolo [2,1-b] [1,3] benzoxazines (1 approximately 9) was isolated from fermentations of an actinomycete strain X10/78/978 (NCIMB40808), identified as Streptomyces rimosus, during a microbial extract screening programme to id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0930be765f889ff138c0476fef57f6
https://doi.org/10.7164/antibiotics.53.1
https://doi.org/10.7164/antibiotics.53.1
Autor:
Steven M. Martin, A. Martyn Ainsworth, Sangeeta Bahl, Philip B. Rawlins, Michael Moore, Jenny S. Tang, Stephen K. Wrigley, David J. Hardick, David A. Kau, Roya Sadheghi
Publikováno v:
ChemInform. 32
A series of reduced benzo[j]fluoranthen-3-ones (1-4) was isolated from fermentations of a fungal strain CBUK20700 (CBS 100220), classified as Cladosporium cf. cladosporioides, during a microbial extract screening programme to identify inhibitors of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0239764c36aee4346ea3330701398796
https://doi.org/10.1002/chin.200140244
https://doi.org/10.1002/chin.200140244
Autor:
Luis Morales-Quinteros, Ary Serpa Neto, Antonio Artigas, Lluis Blanch, Michela Botta, David A. Kaufman, Marcus J. Schultz, Anissa M. Tsonas, Frederique Paulus, Lieuwe D. Bos, the PRoVENT-COVID Study Group
Publikováno v:
Critical Care, Vol 25, Iss 1, Pp 1-13 (2021)
Abstract Background Estimates for dead space ventilation have been shown to be independently associated with an increased risk of mortality in the acute respiratory distress syndrome and small case series of COVID-19-related ARDS. Methods Secondary a
Externí odkaz:
https://doaj.org/article/20fc8eea489546ca809408cbddedaf34
Autor:
Christopher J. Kay, Andrew C. Cannons, Charles R. Hipkin, Larry P. Solomonson, David A. Kau, Michael J. Barber
Publikováno v:
Biochemical Journal. 272:545-548
Visible spectra of oxidized and reduced Candida nitratophila assimilatory NAD(P)H:nitrate reductase yielded absorbance maxima of 413 nm and 423 nm, and 525 nm and 555 nm respectively, characteristic of a b5-type cytochrome. E.p.r. spectra of the part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b82f9cda3f0e3d0d596ed3034150dc3
https://doi.org/10.1042/bj2720545
https://doi.org/10.1042/bj2720545
Autor:
Stephen K. Wrigley, Barbara Waters, Martin A. Hayes, Neville Nicholson, David A. Kau, Ewan J. T. Chrystal, Robert Thomas, Julian Davies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35ebd1b1d2228312ac4a2279e1d53448
https://doi.org/10.1039/9781847550231-00086
https://doi.org/10.1039/9781847550231-00086
Autor:
Richard H. Baltz, Kien T. Nguyen, Stephen K. Wrigley, David A. Kau, Jian-Qiao Gu, Vivian Miao, Paul Brian
Publikováno v:
Molecular microbiology. 61(5)
In many peptide antibiotics, modified amino acids are important for biological activity. The amino acid 3-methyl-glutamic acid (3mGlu) has been found only in three cyclic lipopeptide antibiotics: daptomycin and the A21978C family produced by Streptom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64bb61ae37fcd204d0cd1c7201e94db2
https://pubmed.ncbi.nlm.nih.gov/16879412
https://pubmed.ncbi.nlm.nih.gov/16879412
Publikováno v:
Natural Products Isolation ISBN: 9781588294470
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d823241ece5623958d6cd9d52a77631f
https://doi.org/10.1385/1-59259-955-9:439
https://doi.org/10.1385/1-59259-955-9:439
Autor:
Yangsheng Wanggui, Julian Davies, Stephen K. Wrigley, Richard W. Stokes, Barbara Waters, Geeta Saxena, David A. Kau
Publikováno v:
The Journal of antibiotics. 55(4)
We have identified a strain of Streptomyces in which aerial hyphae formation appears to be especially sensitive to inhibition by protein kinase inhibitors. Using this assay, a number of bacterial cultures have been screened and novel inhibitors of eu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d776052204b35a18ae533f63bdf9af
https://pubmed.ncbi.nlm.nih.gov/12061549
https://pubmed.ncbi.nlm.nih.gov/12061549