Zobrazeno 1 - 10
of 18
pro vyhledávání: '"David A. Karanian"'
Autor:
Andrea M. Zuhl, Charles E. Nolan, Michael A. Brodney, Sherry Niessen, Kevin Atchison, Christopher Houle, David A. Karanian, Claude Ambroise, Jeffrey W. Brulet, Elizabeth M. Beck, Shawn D. Doran, Brian T. O’Neill, Christopher W. am Ende, Cheng Chang, Kieran F. Geoghegan, Graham M. West, Joshua C. Judkins, Xinjun Hou, David R. Riddell, Douglas S. Johnson
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Several β-secretase (BACE) inhibitors exhibit unexplained ocular toxicity in preclinical studies. Here the authors generate a clickable photoaffinity probe to interrogate off-targets in cells and animals, and identify inhibition of cathepsin D as a
Externí odkaz:
https://doaj.org/article/5dfe4a29e6af43a49ee6c24207abc513
Autor:
Heather Romine, Aaron Byrd, Sara A. McEwan, Karen L.G. Farizatto, Michael F. Almeida, Ben A. Bahr, Spyros P. Nikas, Alexandros Makriyannis, Vinogran Naidoo, David A. Karanian, Vidyanand G. Shukla
Publikováno v:
Journal of molecular neuroscience : MN. 63(1)
The anticholinesterase paraoxon (Pxn) is related to military nerve agents that increase acetylcholine levels, trigger seizures, and cause excitotoxic damage in the brain. In rat hippocampal slice cultures, high-dose Pxn was applied resulting in a pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f309fc7570f608f294ef6e0824505075
https://pubmed.ncbi.nlm.nih.gov/28803438
https://pubmed.ncbi.nlm.nih.gov/28803438
Autor:
Johnathan R. Locklear, Vinogran Naidoo, Mahmoud L. Nasr, Pamela M. Quizon, Ben A. Bahr, Vidyanand G. Shukla, JodiAnne T. Wood, Subramanian K. Vadivel, Emily E. Graves, David A. Karanian, Alexandros Makriyannis
Publikováno v:
Neurotherapeutics. 9:801-813
Advances in the understanding of the endogenous cannabinoid system have led to several therapeutic indications for new classes of compounds that enhance cannabinergic responses. Endocannabinoid levels are elevated during pathogenic conditions, and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95916a801c3f5d3a8c42a847d34bb8e
https://doi.org/10.1007/s13311-011-0100-y
https://doi.org/10.1007/s13311-011-0100-y
Autor:
Spyros P. Nikas, Vinogran Naidoo, Alexandros Makriyannis, Jianhong Zhao, Subramanian K. Vadivel, Shakiru O. Alapafuja, David A. Karanian, Ben A. Bahr, Jeannie Hwang, JodiAnne T. Wood, David Butler
Publikováno v:
Journal of Molecular Neuroscience. 43:493-502
Endocannabinoids, including anandamide (AEA), have been implicated in neuroprotective on-demand responses. Related to such a response to injury, an excitotoxic kainic acid (KA) injection (i.p.) was found to increase AEA levels in the brain. To modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f032aa11fd7650e79f04cf6c6e010ec
https://doi.org/10.1007/s12031-010-9472-4
https://doi.org/10.1007/s12031-010-9472-4
Autor:
Ben A. Bahr, Priscilla Kehoe, David A. Karanian, Colin N. Haile, Jeansok J. Kim, Jeannette Yeh, Therese A. Kosten
Publikováno v:
Neurobiology of Learning and Memory. 88:167-176
Early life events have profound consequences. Our research demonstrates that the early life stress of neonatal isolation (1-h individual isolation on postnatal days 2–9) in rats has immediate and enduring neural and behavioral effects. Recently, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fbe892d95b7b7ca7518ec46a4abc797
https://doi.org/10.1016/j.nlm.2007.03.011
https://doi.org/10.1016/j.nlm.2007.03.011
Autor:
Alexandros Makriyannis, Ben A. Bahr, Lakshmipathi Pandarinathan, David A. Karanian, John L. Williams, Paul Vouros, JodiAnne Wood
Publikováno v:
Analytical Chemistry. 79:5582-5593
The endocannabinoid system's biological significance continues to grow as novel endocannabinoid metabolites are discovered. Accordingly, a myopic view of the system that focuses solely on one or two endocannabinoids, such as anandamide or 2-arachidon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d4f78bb5ceecd199939b36e4c30f97
https://doi.org/10.1021/ac0624086
https://doi.org/10.1021/ac0624086
Publikováno v:
Expert Opinion on Investigational Drugs. 15:351-365
Recent cannabinoid research has a primary focus on developing therapeutics against human diseases. Many studies on cannabinoids indicate important progress for protection against several neurodegenerative disorders. Agonists of cannabinoid receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366f665a45d0bce9028e2378093eb6c5
https://doi.org/10.1517/13543784.15.4.351
https://doi.org/10.1517/13543784.15.4.351
Autor:
Manpreet Singh Mutneja, David A. Karanian, Douglas J. Chin, Sanjida Karim, Queenie B. Brown, Ben A. Bahr, David Butler, Lara Batey
Publikováno v:
Rejuvenation Research. 8:227-237
Protein oligomerization and aggregation are key events in age-related neurodegenerative disorders, causing neuronal disturbances including microtubule destabilization, transport failure and loss of synaptic integrity that precede cell death. The abno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901b9b690d99295b305922d6cb8ffa2e
https://doi.org/10.1089/rej.2005.8.227
https://doi.org/10.1089/rej.2005.8.227
Publikováno v:
Neuropsychopharmacology. 22:626-641
Individual differences in locomotor responses to novelty and psychostimulants, and sensitization following repeated drug exposure, predict increased sensitivity to the reinforcing effects of psychostimulants and are thought to underlie vulnerability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ee599b02a33d1dcf3786a011a88419
https://doi.org/10.1016/s0893-133x(99)00160-8
https://doi.org/10.1016/s0893-133x(99)00160-8
Autor:
JodiAnne T. Wood, Alexandros Makriyannis, Emily E. Graves, David A. Karanian, Spyros P. Nikas, Ben A. Bahr, Vinogran Naidoo
Publikováno v:
The FASEB Journal. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a7cb91be7ba5d1018d9687991fb22a7
https://doi.org/10.1096/fasebj.25.1_supplement.lb420
https://doi.org/10.1096/fasebj.25.1_supplement.lb420