Zobrazeno 1 - 10
of 1 538
pro vyhledávání: '"David A. Johnston"'
Autor:
Diana K. Franco-Bocanegra, Yamina Gourari, Ciaran McAuley, David S. Chatelet, David A. Johnston, James A. R. Nicoll, Delphine Boche
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Microglia are the brain immune cells and their function is highly dependent on cell motility. It was hypothesised that morphological variability leads to differences in motility, ultimately impacting on the microglial function. Here, we asse
Externí odkaz:
https://doaj.org/article/f86008062e354063b1e13b8592a0398e
Autor:
Xiaojie Yu, Sonya James, James H. Felce, Blanka Kellermayer, David A. Johnston, H. T. Claude Chan, Christine A. Penfold, Jinny Kim, Tatyana Inzhelevskaya, C. Ian Mockridge, Yasunori Watanabe, Max Crispin, Ruth R. French, Patrick J. Duriez, Leon R. Douglas, Martin J. Glennie, Mark S. Cragg
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Yu et al examined a panel of both experimental and clinically-relevant TNF agonists in order to advance our understanding of the mechanisms underlying their varying activities and anti-tumor responses. They demonstrated that agonists with greater act
Externí odkaz:
https://doaj.org/article/497b996aa1574d6a946f5ee6787fec3f
Autor:
Jacqui Nimmo, David A. Johnston, J. C. Dodart, Matthew T. MacGregor‐Sharp, Roy O. Weller, James A. R. Nicoll, Ajay Verma, Roxana O. Carare
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Accumulation of amyloid beta (Aβ), α‐synuclein (αSyn), and tau in dementias indicates their age‐related failure of elimination from the brain. Aβ is eliminated along basement membranes in walls of cerebral arterioles and
Externí odkaz:
https://doaj.org/article/b871a5cd538848158b9fbc7d7bb6065c
Autor:
Savannah A. Lynn, David A. Johnston, Jenny A. Scott, Rosie Munday, Roshni S. Desai, Eloise Keeling, Ruaridh Weaterton, Alexander Simpson, Dillon Davis, Thomas Freeman, David S. Chatelet, Anton Page, Angela J. Cree, Helena Lee, Tracey A. Newman, Andrew J. Lotery, J. Arjuna Ratnayaka
Publikováno v:
Cells, Vol 10, Iss 2, p 413 (2021)
Alzheimer’s disease-associated amyloid beta (Aβ) proteins accumulate in the outer retina with increasing age and in eyes of age-related macular degeneration (AMD) patients. To study Aβ-induced retinopathy, wild-type mice were injected with nanomo
Externí odkaz:
https://doaj.org/article/d442198e469c40d1a0b5154e1a50840f
Autor:
Wendy S. Smith, David A. Johnston, Harrison J. Wensley, Suzanne E. Holmes, Sopsamorn U. Flavell, David J. Flavell
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8734 (2020)
Cholesterol seems to play a central role in the augmentation of saporin-based immunotoxin (IT) cytotoxicity by triterpenoid saponins. Endolysosomal escape has been proposed as one mechanism for the saponin-mediated enhancement of targeted toxins. We
Externí odkaz:
https://doaj.org/article/fb969cae59384a43b231a91df65dd8df
Autor:
Eloise Keeling, Annabelle J. Culling, David A. Johnston, David S. Chatelet, Anton Page, David A. Tumbarello, Andrew J. Lotery, J. Arjuna Ratnayaka
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6647 (2020)
Impaired cargo trafficking and the aggregation of intracellular macromolecules are key features of neurodegeneration, and a hallmark of aged as well as diseased retinal pigment epithelial (RPE) cells in the eye. Here, photoreceptor outer segments (PO
Externí odkaz:
https://doaj.org/article/5dcc36e5bd0f4fe0a9bddbb0d0ab42f9
Autor:
Asish K. Kundu, Xiong Huang, Eric Seewald, Ethan Ritz, Santanu Pakhira, Shuai Zhang, Dihao Sun, Simon Turkel, Sara Shabani, Turgut Yilmaz, Elio Vescovo, Cory R. Dean, David C. Johnston, Tonica Valla, Turan Birol, Dmitri N. Basov, Rafael M. Fernandes, Abhay N. Pasupathy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Kagome vanadates AV3Sb5 display unusual low-temperature electronic properties including charge density waves (CDW), whose microscopic origin remains unsettled. Recently, CDW order has been discovered in a new material ScV6Sn6, providing an o
Externí odkaz:
https://doaj.org/article/382a1e46c5f64b4e8bb5aad778cf86c1
Autor:
Savannah A. Lynn, Eloise Keeling, Jennifer M. Dewing, David A. Johnston, Anton Page, Angela J. Cree, David A. Tumbarello, Tracey A. Newman, Andrew J. Lotery, J. Arjuna Ratnayaka
Publikováno v:
F1000Research, Vol 7 (2018)
The retinal pigment epithelium (RPE) plays a key role in the pathogenesis of several blinding retinopathies. Alterations to RPE structure and function are reported in Age-related Macular Degeneration, Stargardt and Best disease as well as pattern dys
Externí odkaz:
https://doaj.org/article/806a7f95156b4dba8deadf7db67b425d
Autor:
Wendy S. Smith, David A. Johnston, Suzanne E. Holmes, Harrison J. Wensley, Sopsamorn U. Flavell, David J. Flavell
Publikováno v:
Toxins, Vol 11, Iss 2, p 127 (2019)
Triterpenoid saponins from Saponinum album (SA) significantly augment the cytotoxicity of saporin-based immunotoxins but the mechanism of augmentation is not fully understood. We investigated the effects of six small molecule pharmacological agents,
Externí odkaz:
https://doaj.org/article/833679c267eb49f9bde90e8bb95ed9a9
Publikováno v:
Journal of Computer Science and Technology, Vol 13, Iss 02, Pp 91-96 (2013)
The introduction of mobile wireless devices brings unique challenges for distribution of data to many devices simultaneously. An optimizing multicast methodology called Probabilistic Multicast Trees (PMT) is extended to handle mobile wireless devices
Externí odkaz:
https://doaj.org/article/2ea3d0bcb2b44b59b52421f50eb20cc9