Zobrazeno 1 - 10
of 15
pro vyhledávání: '"David A. Janowick"'
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 34K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd0a58f7cbd736328e57e7a23f7e5ec
https://doi.org/10.1158/1078-0432.22446309.v1
https://doi.org/10.1158/1078-0432.22446309.v1
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
Purpose: Small-molecule inhibitors of Aurora A (AAK) and B (ABK) kinases, which play important roles in mitosis, are currently being pursued in oncology clinical trials. We developed three novel assays to quantitatively measure biomarkers of AAK inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2b8c17037133a1bc1c17abc8089fa3
https://doi.org/10.1158/1078-0432.c.6520713
https://doi.org/10.1158/1078-0432.c.6520713
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 27K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::889d43f96b1d811fca5e3c164e018a19
https://doi.org/10.1158/1078-0432.22446306
https://doi.org/10.1158/1078-0432.22446306
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 65K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9737acec25fe2137ea4f1aa5f53a36c5
https://doi.org/10.1158/1078-0432.22446312.v1
https://doi.org/10.1158/1078-0432.22446312.v1
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 36K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fa6e54e4641152cddff0837b8a5697
https://doi.org/10.1158/1078-0432.22446315
https://doi.org/10.1158/1078-0432.22446315
Autor:
Todd B. Sells, Ryan Chau, Jeffrey A. Ecsedy, Rachel E. Gershman, Kara Hoar, Jessica Huck, David A. Janowick, Vivek J. Kadambi, Patrick J. LeRoy, Matthew Stirling, Stephen G. Stroud, Tricia J. Vos, Gabriel S. Weatherhead, Deborah R. Wysong, Mengkun Zhang, Suresh K. Balani, Joseph B. Bolen, Mark G. Manfredi, Christopher F. Claiborne
Publikováno v:
ACS Medicinal Chemistry Letters. 6:630-634
The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, select
Autor:
Vaishali Shinde, Stephen G. Stroud, Melissa S. Germanos, Mengkun Zhang, Wei Chen, Sells Todd B, Deborah R. Wysong, Arijit Chakravarty, Matthew D. Silva, Marc L. Hyer, Mark Manfredi, Christopher F. Claiborne, Jeffrey Ecsedy, Patrick J. LeRoy, Jessica Huck, Lee Silverman, David A. Janowick, Kara Hoar, Joseph B. Bolen, Rachel E. Gershman
Publikováno v:
Clinical Cancer Research. 17:7614-7624
Purpose: Small-molecule inhibitors of Aurora A (AAK) and B (ABK) kinases, which play important roles in mitosis, are currently being pursued in oncology clinical trials. We developed three novel assays to quantitatively measure biomarkers of AAK inhi
Autor:
William A. Metz, Timothy C McCloskey, Scott Meikrantz, Boyd L. Harrison, Bruce Baron, Dirk Friedrich, Farr Robert A, Gross Raymond S, Robert J. Cregge, Roy J. Vaz, Donald Matthews, David A. Janowick, Philip L Nyce
Publikováno v:
Journal of Medicinal Chemistry. 48:995-1018
(E)-3-(2-Carboxy-2-phenylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acid, 1, is a potent and selective antagonist of the glycine site of the N-methyl-d-aspartate (NMDA) receptor. Using 3D comparative molecular field analysis (CoMFA) to guide the synt
Autor:
Michael A. Stashko, Cele Abad-Zapatero, Bruce G. Szczepankiewicz, Michael R. Jirousek, Zhonghua Pei, Cathy Berg, Gang Liu, Stephen J. Ballaron, Zhili Xin, Philip J. Hajduk, Thomas H. Lubben, Heng Liang, Charles W. Hutchins, David A. Janowick, Cristina M. Rondinone, James M. Trevillyan
Publikováno v:
Journal of Medicinal Chemistry. 46:3437-3440
Protein tyrosine phosphatase (PTPase) 1B (PTP1B) has been implicated as a key negative regulator of both insulin and leptin signaling cascades. We identified several salicylic acid-based ligands for the second phosphotyrosine binding site of PTP1B us
Autor:
Ping Zhong, Philip J. Hajduk, Rachel Hammond, Vicki L. Nienaber, Bruce A. Beutel, David J. Augeri, Michael L. Coen, David A. Janowick, Jeffrey M. Schkeryantz, Jürgen Dinges, Kaminski Michele A, Stephen W. Fesik, Leonard Katz, Michael D. Tufano, Andrew M. Petros
Publikováno v:
Journal of Medicinal Chemistry. 42:3852-3859
The Erm family of methyltransferases confers resistance to the macrolide-lincosamide-streptogramin type B (MLS) antibiotics through the methylation of 23S ribosomal RNA. Upon the methylation of RNA, the MLS antibiotics lose their ability to bind to t