Zobrazeno 1 - 10
of 554
pro vyhledávání: '"David A. JANS"'
Autor:
Alexander J. Martin, David M. Shackleford, Susan A. Charman, Kylie M. Wagstaff, Christopher J. H. Porter, David A. Jans
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1974 (2023)
N-(4-hydroxyphenyl) retinamide (4-HPR, or fenretinide) has promising in vitro and in vivo antiviral activity against a range of flaviviruses and an established safety record, but there are challenges to its clinical use. This study evaluated the in v
Externí odkaz:
https://doaj.org/article/2a1e9a8fc4ec461b8d615f90a672e66c
Publikováno v:
Cells, Vol 12, Iss 9, p 1311 (2023)
Although respiratory syncytial virus (RSV) is the most common cause of respiratory infection in infants, immunosuppressed adults and the elderly worldwide, there is no licensed RSV vaccine or widely applicable antiviral therapeutics We previously rep
Externí odkaz:
https://doaj.org/article/3286055a6c854ccabb11695be75bb981
Publikováno v:
Data in Brief, Vol 42, Iss , Pp 108099- (2022)
The transcriptional response to cellular stress relies upon trafficking of regulators of transcription between the nuclear and cytoplasmic compartments, which occurs through action of members of the importin (IPO) superfamily. As a result of stresses
Externí odkaz:
https://doaj.org/article/b28b2971f773457fbc70f12892a534e8
Autor:
Bikshapathi Jagga, Megan Edwards, Miriam Pagin, Kylie M. Wagstaff, David Aragão, Noelia Roman, Jeffrey D. Nanson, Shane R. Raidal, Nicole Dominado, Murray Stewart, David A. Jans, Gary R. Hime, Silvia K. Nicolis, Christopher F. Basler, Jade K. Forwood
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The SOX2 pioneer transcription factor performs critical roles in pluripotency and self-renewal of embryonic stem cells. Here the authors show that SOX2’s two nuclear localization signal sequences form a contiguous binding interface on the nuclear i
Externí odkaz:
https://doaj.org/article/213cab1ef68b41cbaac148926dd0be5d
Autor:
Sunyuan Zhang, Nicholas A. Williamson, Lisa Duvick, Alexander Lee, Harry T. Orr, Austin Korlin-Downs, Praseuth Yang, Yee-Foong Mok, David A. Jans, Marie A. Bogoyevitch
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Patients with spinocerebellar ataxia type 1 express ataxin-1 with an extended polyglutamine (polyQ) tract that forms distinctive nuclear bodies. Here, the authors characterize the cellular pathways affected by polyQ-ataxin-1, showing that it disrupts
Externí odkaz:
https://doaj.org/article/b2b32690cddc4b05a5d62aa6d6b893b2
Publikováno v:
Cells, Vol 12, Iss 2, p 279 (2023)
The cellular response to environmental stresses, such as heat and oxidative stress, is dependent on extensive trafficking of stress-signalling molecules between the cytoplasm and nucleus, which potentiates stress-activated signalling pathways, eventu
Externí odkaz:
https://doaj.org/article/a00367e302624244ae4f6959a9db25c5
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13899 (2022)
Signal-dependent transport into and out of the nucleus mediated by members of the importin (IMP) superfamily of nuclear transporters is critical to the eukaryotic function and a point of therapeutic intervention with the potential to limit disease pr
Externí odkaz:
https://doaj.org/article/525be17ec82c4935b8123417d13bf821
Autor:
Reena Ghildyal, Michael N. Teng, Kim C. Tran, John Mills, Marco G. Casarotto, Philip G. Bardin, David A. Jans
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7976 (2022)
Respiratory syncytial virus (RSV) is a major cause of respiratory infections in infants and the elderly. Although the RSV matrix (M) protein has key roles in the nucleus early in infection, and in the cytoplasm later, the molecular basis of switching
Externí odkaz:
https://doaj.org/article/12c2b8e768624e24aed6f50d71d51a84
Publikováno v:
Cells, Vol 11, Iss 12, p 1904 (2022)
Molecular transport between the nucleus and cytoplasm of the cell is mediated by the importin superfamily of transport receptors, of which the bidirectional transporter Importin 13 (IPO13) is a unique member, with a critical role in early embryonic d
Externí odkaz:
https://doaj.org/article/8279f42f1fd643eba5cebb61f7816541
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
The development of new drugs is costly and time-consuming, with estimates of over $US1 billion and 15 years for a product to reach the market. As understanding of the molecular basis of disease improves, various approaches have been used to target sp
Externí odkaz:
https://doaj.org/article/20208f1b01864bf1bed112ea2053feee