Zobrazeno 1 - 10
of 822
pro vyhledávání: '"David A. Hume"'
Autor:
Sepideh Kiani Shabestari, Samuel Morabito, Emma Pascal Danhash, Amanda McQuade, Jessica Ramirez Sanchez, Emily Miyoshi, Jean Paul Chadarevian, Christel Claes, Morgan Alexandra Coburn, Jonathan Hasselmann, Jorge Hidalgo, Kayla Nhi Tran, Alessandra C. Martini, Winston Chang Rothermich, Jesse Pascual, Elizabeth Head, David A. Hume, Clare Pridans, Hayk Davtyan, Vivek Swarup, Mathew Blurton-Jones
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110961- (2022)
Summary: Microglia are strongly implicated in the development and progression of Alzheimer’s disease (AD), yet their impact on pathology and lifespan remains unclear. Here we utilize a CSF1R hypomorphic mouse to generate a model of AD that genetica
Externí odkaz:
https://doaj.org/article/def9c689b7ba47e59182ba5cb0a6929b
Autor:
Omkar L. Patkar, Abdalla Z. Mohamed, Ashwin Narayanan, Karine Mardon, Gary Cowin, Rajiv Bhalla, Damion H. R. Stimson, Michael Kassiou, Kate Beecher, Arnauld Belmer, Ignatius Alvarez Cooper, Michael Morgan, David A. Hume, Katharine M. Irvine, Selena E. Bartlett, Fatima Nasrallah, Paul Cumming
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract While the dire cardiometabolic consequences of the hypercaloric modern ‘Western’ diet are well known, there is not much information on the health impact of a high sucrose diet not inducing weight gain. Here, we tested the hypothesis that
Externí odkaz:
https://doaj.org/article/c523c0f955e34761879d7926be4d415f
Autor:
Sahar Keshvari, Berit Genz, Ngari Teakle, Melanie Caruso, Michelle F. Cestari, Omkar L. Patkar, Brian W. C. Tse, Kamil A. Sokolowski, Hilmar Ebersbach, Julia Jascur, Kelli P. A. MacDonald, Gregory Miller, Grant A. Ramm, Allison R. Pettit, Andrew D. Clouston, Elizabeth E. Powell, David A. Hume, Katharine M. Irvine
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 4 (2022)
Resident and recruited macrophages control the development and proliferation of the liver. We have previously shown in multiple species that treatment with a macrophage colony stimulating factor (CSF1)-Fc fusion protein initiated hepatocyte prolifera
Externí odkaz:
https://doaj.org/article/9b4f9a4ccdaa4fd4b6ee2680c8ac5715
Autor:
Simranpreet Kaur, Anuj Sehgal, Andy C. Wu, Susan M. Millard, Lena Batoon, Cheyenne J. Sandrock, Michelle Ferrari-Cestari, Jean-Pierre Levesque, David A. Hume, Liza J. Raggatt, Allison R. Pettit
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-19 (2021)
Abstract Background Prior chemotherapy and/or underlying morbidity commonly leads to poor mobilisation of hematopoietic stem cells (HSC) for transplantation in cancer patients. Increasing the number of available HSC prior to mobilisation is a potenti
Externí odkaz:
https://doaj.org/article/a35dbeec550140e9ade7a9eec3072d08
Autor:
Androniki Psifidi, Andreas Kranis, Lisa M. Rothwell, Abi Bremner, Kay Russell, Diego Robledo, Stephen J. Bush, Mark Fife, Paul M. Hocking, Georgios Banos, David A. Hume, Jim Kaufman, Richard A. Bailey, Santiago Avendano, Kellie A. Watson, Pete Kaiser, Mark. P. Stevens
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Campylobacter is the leading cause of bacterial foodborne gastroenteritis worldwide. Handling or consumption of contaminated poultry meat is a key risk factor for human campylobacteriosis. One potential control strategy is to select poultry
Externí odkaz:
https://doaj.org/article/7e1f6472c34c49b9b1c83a773c652d42
Autor:
Prasun Dutta, Andrea Talenti, Rachel Young, Siddharth Jayaraman, Rebecca Callaby, Santosh Kumar Jadhav, Velu Dhanikachalam, Mayakannan Manikandan, Bhim B. Biswa, Wai Y. Low, John L. Williams, Elizabeth Cook, Phil Toye, Eileen Wall, Appolinaire Djikeng, Karen Marshall, Alan L. Archibald, Suresh Gokhale, Satish Kumar, David A. Hume, James G. D. Prendergast
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The comparative genomics of domesticated lineages can yield insights into the signatures of artificial selection. This study sequences 79 water buffalo genomes from 7 breeds and reveals examples of convergent domestication at the genetic level betwee
Externí odkaz:
https://doaj.org/article/ec8018ffcfa040fca619b70f69cacf2d
Autor:
Iveta Gažová, Lucas Lefevre, Stephen J. Bush, Rocio Rojo, David A. Hume, Andreas Lengeling, Kim M. Summers
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
USP16 is a histone deubiquitinase which facilitates G2/M transition during the cell cycle, regulates DNA damage repair and contributes to inducible gene expression. We mutated the USP16 gene in a high differentiation clone of the acute monocytic leuk
Externí odkaz:
https://doaj.org/article/007df63a40774d17a153ba289c1c7a34
Autor:
Omkar L. Patkar, Melanie Caruso, Ngari Teakle, Sahar Keshvari, Stephen J. Bush, Clare Pridans, Arnauld Belmer, Kim M. Summers, Katharine M. Irvine, David A. Hume
Publikováno v:
Neurobiology of Disease, Vol 151, Iss , Pp 105268- (2021)
Mutations in the human CSF1R gene have been associated with dominant and recessive forms of neurodegenerative disease. Here we describe the impacts of Csf1r mutation in the rat on development of the brain. Diffusion imaging indicated small reductions
Externí odkaz:
https://doaj.org/article/511dbe99f70844778390ac483938cb1c
Autor:
Rocío Rojo, Anna Raper, Derya D. Ozdemir, Lucas Lefevre, Kathleen Grabert, Evi Wollscheid-Lengeling, Barry Bradford, Melanie Caruso, Iveta Gazova, Alejandra Sánchez, Zofia M. Lisowski, Joana Alves, Irene Molina-Gonzalez, Hayk Davtyan, Rebecca J. Lodge, James D. Glover, Robert Wallace, David A. D. Munro, Eyal David, Ido Amit, Véronique E. Miron, Josef Priller, Stephen J. Jenkins, Giles E. Hardingham, Mathew Blurton-Jones, Neil A. Mabbott, Kim M. Summers, Peter Hohenstein, David A. Hume, Clare Pridans
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
The lineage-specific receptor CSF1R controls macrophage development and homeostasis. Here the authors show that deletion of a conserved Csf1r enhancer (FIRE) selectively depletes brain microglia and resident macrophages in the epidermis, kidney, hear
Externí odkaz:
https://doaj.org/article/f7dcb1c551fc424bb8707e117d441d06
Autor:
Stephen J. Bush, Mary E. B. McCulloch, Charity Muriuki, Mazdak Salavati, Gemma M. Davis, Iseabail L. Farquhar, Zofia M. Lisowski, Alan L. Archibald, David A. Hume, Emily L. Clark
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 2, Pp 359-373 (2019)
One of the most significant physiological challenges to neonatal and juvenile ruminants is the development and establishment of the rumen. Using a subset of RNA-Seq data from our high-resolution atlas of gene expression in sheep (Ovis aries) we have
Externí odkaz:
https://doaj.org/article/73da7c1940804333b770fb689ad6c742