Zobrazeno 1 - 10
of 43
pro vyhledávání: '"David A. Hales"'
Autor:
Alison McNeal, David A. Hales
Publikováno v:
Utah Historical Quarterly. 90:312-326
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f43e154bdb297f0ab7eb80ba9b64d52b
https://doi.org/10.5406/26428652.90.4.04
https://doi.org/10.5406/26428652.90.4.04
Publikováno v:
Journal of the American Society for Mass Spectrometry. 33:1368-1376
Diketopiperazine (DKP) formation is an important degradation pathway for peptides and proteins. It can occur during synthesis and storage in either solution or the solid state. The kinetics of peptide cleavage through DKP formation have been analyzed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30088284f3521bada6510e19772fe950
https://doi.org/10.1021/jasms.2c00037
https://doi.org/10.1021/jasms.2c00037
Autor:
Daniel R. Fuller, Zhichao Zhang, David A. Hales, Christopher R. Conant, Shannon A. Raab, David E. Clemmer, Tarick J. El-Baba
Publikováno v:
The Journal of Physical Chemistry B. 125:8107-8116
Peptides with penultimate proline residues undergo trans → cis isomerization of the Phe1-Pro2 peptide bond followed by spontaneous bond cleavage at the Pro2-Xxx3 bond (where Xxx is another amino acid residue), leading to cleavage of the Pro2-Xxx3 b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f283d13d379476eefa025d2bd16162b
https://doi.org/10.1021/acs.jpcb.1c03515
https://doi.org/10.1021/acs.jpcb.1c03515
Publikováno v:
The Journal of Physical Chemistry B. 125:2952-2959
Ion mobility spectrometry (IMS) and mass spectrometry (MS) techniques were used to monitor diketopiperazine (DKP) formation from the peptide FPG8K at multiple defined temperatures in methanol, ethanol, propanol, and water, with the motivation to stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81d3cc7dd77b91176fc3b438b0bf7aea
https://doi.org/10.1021/acs.jpcb.1c00269
https://doi.org/10.1021/acs.jpcb.1c00269
Autor:
Zhichao, Zhang, Christopher R, Conant, Tarick J, El-Baba, Shannon A, Raab, Daniel R, Fuller, David A, Hales, David E, Clemmer
Publikováno v:
The journal of physical chemistry. B. 125(29)
Peptides with penultimate proline residues undergo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16ab18acb73799706b61589653f4d41f
https://pubmed.ncbi.nlm.nih.gov/34270248
https://pubmed.ncbi.nlm.nih.gov/34270248
Publikováno v:
J Phys Chem B
Ion mobility spectrometry (IMS) and mass spectrometry (MS) techniques were used to monitor diketopiperazine (DKP) formation from the peptide FPG(8)K at multiple defined temperatures in methanol, ethanol, propanol, and water, with the motivation to st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a538d805131e8de848c43e2f121782a
https://pubmed.ncbi.nlm.nih.gov/33689329
https://pubmed.ncbi.nlm.nih.gov/33689329
Autor:
Yang Liu, Arthur Laganowsky, Wen Liu, David H. Russell, David E. Clemmer, Shannon A. Raab, David A. Hales, Tarick J. El-Baba, Zane Baird, Daniel W. Woodall
Publikováno v:
J Am Chem Soc
Chymotrypsin inhibitor 2 (CI-2) is a classic model for two-state cooperative protein folding and is one of the most extensively studied systems. Alan Fersht, a pioneer in the field of structural biology, has studied the wild-type (wt) and over 100 mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7171bc093587807a14489f7f963507ef
https://pubmed.ncbi.nlm.nih.gov/32866376
https://pubmed.ncbi.nlm.nih.gov/32866376
Publikováno v:
Journal of the American Society for Mass Spectrometry. 30:77-84
Ion mobility spectrometry and circular dichroism spectroscopy are used to examine the populations of the small model peptide, polyproline-13 in water, methanol, ethanol, and 1-propanol over a range of solution temperatures (from 288 to 318 K). At low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb54c5096114096ad4276e5333aab6cf
https://doi.org/10.1007/s13361-018-2034-7
https://doi.org/10.1007/s13361-018-2034-7
Autor:
Connie S Zhang, Zhichao Zhang, David A. Hales, Kameron R Molloy, Tarick J. El-Baba, Daniel R. Fuller, Christopher R. Conant, David E. Clemmer
Publikováno v:
Eur J Mass Spectrom (Chichester)
Biomolecular degradation plays a key role in proteostasis. Typically, proteolytic enzymes degrade proteins into smaller peptides by breaking amino acid bonds between specific residues. Cleavage around proline residues is often missed and requires hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec3806ee160a27ab8129114ca8bf81b
https://europepmc.org/articles/PMC7702224/
https://europepmc.org/articles/PMC7702224/
Autor:
David A. Hales, Xuewei Dong, Ehud Gazit, Bankala Krishnarjuna, Guanghong Wei, Ayyalusamy Ramamoorthy, Santu Bera, Shannon A. Raab, Yiming Tang, Linda J. W. Shimon, David E. Clemmer, Wei Ji
Publikováno v:
Cell Reports. Physical Science
Summary The understanding and prediction of the solubility of biomolecules, even of the simplest ones, reflect an open question and unmet need. Short aromatic tripeptides are among the most highly aggregative biomolecules. However, in marked contrast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970e8d93cd2039615945ed504dcd7c2f
https://doi.org/10.1016/j.xcrp.2021.100391
https://doi.org/10.1016/j.xcrp.2021.100391