Zobrazeno 1 - 10
of 13
pro vyhledávání: '"David A. Griffiths-Johnson"'
Autor:
Dolores M Conroy, Alison A Humbles, Sara M Rankin, Roger T Palframan, Paul D Collins, David A Griffiths-Johnson, Peter J Jose, Timothy J Williams
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 92, Pp 183-191 (1997)
Blood eosinophilia and tissue infiltration by eosinophils are frequently observed in allergic inflammation and parasitic infections. This selective accumulation of eosinophils suggested the existence of endogenous eosinophil-selective chemoattractant
Externí odkaz:
https://doaj.org/article/d426755c424140f5829a1315f0dc482c
Autor:
Sara M. Rankin, David A. Griffiths-Johnson, Alison A. Humbles, Paul D. Collins, Roger T. Palframan, Timothy J. Williams, Dolores M. Conroy, Peter J. Jose
Publikováno v:
Memórias do Instituto Oswaldo Cruz, Volume: 92 Supplement 2, Pages: 183-191, Published: DEC 1997
Memórias do Instituto Oswaldo Cruz., Vol 92, Pp 183-191 (1997)
Memórias do Instituto Oswaldo Cruz., Vol 92, Iss suppl.2, Pp 183-191 (1997)
Memórias do Instituto Oswaldo Cruz., Vol 92, Pp 183-191 (1997)
Memórias do Instituto Oswaldo Cruz., Vol 92, Iss suppl.2, Pp 183-191 (1997)
Blood eosinophilia and tissue infiltration by eosinophils are frequently observed in allergic inflammation and parasitic infections. This selective accumulation of eosinophils suggested the existence of endogenous eosinophil-selective chemoattractant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ac98b4252d5c054d0b23246d3f1d9d
https://doi.org/10.1590/s0074-02761997000800024
https://doi.org/10.1590/s0074-02761997000800024
Autor:
Roger T. Palframan, Amanda E. I. Proudfoot, Sara M. Rankin, Sylvie Marleau, David A. Griffiths-Johnson, Peter J. Jose, Timothy N. C. Wells, Dolores M. Conroy, Peter K. Jeffery, Alison A. Humbles, Dechun Li, Timothy J. Williams
Publikováno v:
The Journal of Experimental Medicine
Challenge of the airways of sensitized guinea pigs with aerosolized ovalbumin resulted in an early phase of microvascular protein leakage and a delayed phase of eosinophil accumulation in the airway lumen, as measured using bronchoalveolar lavage (BA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfea4b7218e04e929fdb302bb785245c
https://doi.org/10.1084/jem.186.4.601
https://doi.org/10.1084/jem.186.4.601
Autor:
Peter J. Jose, N. Berkman, C.A. Power, T.N.C. Wells, Timothy J. Williams, Ian M. Adcock, David A. Griffiths-Johnson
Publikováno v:
Biochemical and Biophysical Research Communications. 205:788-794
Eotaxin was recently identified as the major eosinophil chemoattractant in bronchoalveolar lavage fluid obtained 3h after allergen challenge of sensitised guinea-pigs. We now report the cDNA cloning of this C-C chemokine. The 777 base-pair clone, pEo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3081c52d1fea776a55e0677db1533926
https://doi.org/10.1006/bbrc.1994.2734
https://doi.org/10.1006/bbrc.1994.2734
Publikováno v:
Biochemical and Biophysical Research Communications. 197:1167-1172
Eotaxin is a novel C-C chemokine purified from the bronchoalveolar lavage (BAL) fluid of actively sensitised guinea-pigs after aerosol allergen challenge. In this study we show that eotaxin induced a dose-dependent increase in both intracellular-free
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00b8118afdac04887b2499c17fa0e84
https://doi.org/10.1006/bbrc.1993.2599
https://doi.org/10.1006/bbrc.1993.2599
Publikováno v:
Journal of Toxicology and Environmental Health. 40:117-127
Guinea pigs have been used extensively to model pulmonary hypersensitivity responses. Although guinea pigs produce mainly immunoglobulin G1 (IgG1) antibodies and humans produce IgE, both immunoglobulin classes have been shown to be regulated similarl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5f57310828546f45ea1cb1712f07417
https://doi.org/10.1080/15287399309531779
https://doi.org/10.1080/15287399309531779
Publikováno v:
Inhalation Toxicology. 3:405-417
An animal model for organic dust toxic syndrome (ODTS) was developed using the guinea pig. Animals were exposed to airborne cotton dust at 78–33 mg m−3 for 6 h. A febrile response of 1.1–1.5°C occurred by 5 h and lasted for several hours. Conc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5022f317d9fcd5583883595ca3e351f4
https://doi.org/10.3109/08958379109145298
https://doi.org/10.3109/08958379109145298
Publikováno v:
Methods in Enzymology ISBN: 9780121821890
In studies of disease processes, increasing knowledge leads to an increased awareness of the complexity of the underlying mechanisms. The intense research activity in the chemokine field has made this acutely manifest. Numerous chemokines have been d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e12c7cd726a1029eba9dfe727989641
https://doi.org/10.1016/s0076-6879(97)88018-4
https://doi.org/10.1016/s0076-6879(97)88018-4
Publikováno v:
The Journal of Experimental Medicine
Experiments were designed to study the effect of systemically administered IL-5 on local eosinophil accumulation induced by the intradermal injection of the chemokine eotaxin in the guinea pig. Intravenous interleukin-5 (IL-5) stimulated a rapid and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affbc100ce93aea366c37a034f63b178
http://hdl.handle.net/10044/1/28151
http://hdl.handle.net/10044/1/28151
Publikováno v:
Novel Molecular Approaches to Anti-Inflammatory Therapy ISBN: 9783034872782
The eosinophil is the predominant inflammatory cell which accumulates in the asthmatic lung. There is considerable circumstantial evidence linking these cells to lung dysfunction, but the precise cause and effect relationship is controversial. The de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ba9218966889be4fb5320b3286fcbf2
https://doi.org/10.1007/978-3-0348-7276-8_1
https://doi.org/10.1007/978-3-0348-7276-8_1