Zobrazeno 1 - 10
of 134
pro vyhledávání: '"David A. Goldhamer"'
Autor:
Lorraine N. Burdick, Amanda H. DelVichio, L. Russell Hanson, Brenden B. Griffith, Keith R. Bouchard, Jeffrey W. Hunter, David J. Goldhamer
Publikováno v:
Biomolecules, Vol 14, Iss 2, p 177 (2024)
Heterotopic ossification (HO) is most dramatically manifested in the rare and severely debilitating disease, fibrodysplasia ossificans progressiva (FOP), in which heterotopic bone progressively accumulates in skeletal muscles and associated soft tiss
Externí odkaz:
https://doaj.org/article/0323a404739f4c11b0368c825cba807f
Autor:
John B. Lees-Shepard, Sean J. Stoessel, Julian T. Chandler, Keith Bouchard, Patricia Bento, Lorraine N. Apuzzo, Parvathi M. Devarakonda, Jeffrey W. Hunter, David J. Goldhamer
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 12 (2022)
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by progressive and catastrophic heterotopic ossification (HO) of skeletal muscle and associated soft tissues. FOP is caused by dominantly acting mutations in the gene
Externí odkaz:
https://doaj.org/article/d1d78e06be5a433aa33e6845557009ed
Autor:
Giselle A. Joseph, Margaret Hung, Aviva J. Goel, Mingi Hong, Marysia-Kolbe Rieder, Noam D. Beckmann, Madhavika N. Serasinghe, Jerry E. Chipuk, Parvathi M. Devarakonda, David J. Goldhamer, Paulina Aldana-Hernandez, Jonathan Curtis, René L. Jacobs, Robert S. Krauss
Publikováno v:
Skeletal Muscle, Vol 9, Iss 1, Pp 1-17 (2019)
Abstract Background Group I Paks are serine/threonine kinases that function as major effectors of the small GTPases Rac1 and Cdc42, and they regulate cytoskeletal dynamics, cell polarity, and transcription. We previously demonstrated that Pak1 and Pa
Externí odkaz:
https://doaj.org/article/31317f8c00e84f5db79bb5fc800436e5
Autor:
Masakazu Yamamoto, Nicholas P. Legendre, Arpita A. Biswas, Alexander Lawton, Shoko Yamamoto, Shahragim Tajbakhsh, Gabrielle Kardon, David J. Goldhamer
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 956-969 (2018)
Summary: MyoD and Myf5 are fundamental regulators of skeletal muscle lineage determination in the embryo, and their expression is induced in satellite cells following muscle injury. MyoD and Myf5 are also expressed by satellite cell precursors develo
Externí odkaz:
https://doaj.org/article/9b4548a4ca7e458ca4e98e0ced50c621
Autor:
John B. Lees-Shepard, Masakazu Yamamoto, Arpita A. Biswas, Sean J. Stoessel, Sarah-Anne E. Nicholas, Cathy A. Cogswell, Parvathi M. Devarakonda, Michael J. Schneider, Samantha M. Cummins, Nicholas P. Legendre, Shoko Yamamoto, Vesa Kaartinen, Jeffrey W. Hunter, David J. Goldhamer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Fibrodysplasia ossificans progressiva is a severe disorder characterized by heterotopic ossification, and is caused by mutations in ACVR1. Here, the authors show that expression of mutant ACVR1 in fibro/adipogenic progenitors recapitulates disease pr
Externí odkaz:
https://doaj.org/article/cce620ded4304ad1a71c991a24918aac
Publikováno v:
Journal of Bone and Mineral Research. 37:2077-2093
Fibrodysplasia ossificans progressiva (FOP) is a devastating disease of progressive heterotopic bone formation for which effective treatments are currently unavailable. FOP is caused by dominant gain-of-function mutations in the receptor ACVR1 (also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a822c3aab63d0b6c232a64e8e0c39df
https://doi.org/10.1002/jbmr.4617
https://doi.org/10.1002/jbmr.4617
Autor:
David J Goldhamer, John B Lees-Shepard
Publikováno v:
eLife, Vol 8 (2019)
We respond to concerns expressed by Pacifici and Shore (2019) about a recent paper (Lees-Shepard and Goldhamer, 2018a) in which we reported that the drug palovarotene can have severe side effects in a mouse model of fibrodysplasia ossificans progress
Externí odkaz:
https://doaj.org/article/b3acad07ff6846baac3cd4fa3aaa5d59
Autor:
John B Lees-Shepard, Sarah-Anne E Nicholas, Sean J Stoessel, Parvathi M Devarakonda, Michael J Schneider, Masakazu Yamamoto, David J Goldhamer
Publikováno v:
eLife, Vol 7 (2018)
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by debilitating heterotopic ossification (HO). The retinoic acid receptor gamma agonist, palovarotene, and antibody-mediated activin A blockade have entered human cl
Externí odkaz:
https://doaj.org/article/a67397fb4bc442cf9f3548431a220bd8
Autor:
Sean J. Stoessel, John B Lees-Shepard, Patricia Bento, Keith Bouchard, Jeffrey W. Hunter, David J. Goldhamer, Lorraine N. Apuzzo, Julian Chandler, Parvathi M. Devarakonda
Publikováno v:
Journal of Clinical Investigation. 132
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by progressive and catastrophic heterotopic ossification (HO) of skeletal muscle and associated soft tissues. FOP is caused by dominantly acting mutations in the bone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a067cac4b9446765fde51fe426766b
https://doi.org/10.1172/jci153795
https://doi.org/10.1172/jci153795
