Zobrazeno 1 - 10
of 124
pro vyhledávání: '"David A. Gell"'
Autor:
Jin-Long Gao, Ann H. Kwan, Anthony Yammine, Xiaoyan Zhou, Jill Trewhella, Barbara M. Hugrass, Daniel A. T. Collins, James Horne, Ping Ye, Derek Harty, Ky-Anh Nguyen, David A. Gell, Neil Hunter
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The pathogenic bacterium Porphyromonas gingivalis causes periodontal disease and depends on porphyrin from host sources. Here the authors show that the P. gingivalis haem uptake system protein A (HusA) mediates the uptake of exogenous porphyrin, pres
Externí odkaz:
https://doaj.org/article/e9830d61b97349769f8267ca4421698e
Publikováno v:
Pathogens, Vol 10, Iss 5, p 577 (2021)
Nontypeable Haemophilus influenzae (NTHi) is a major respiratory pathogen that initiates infection by colonising the upper airways. Strategies that interfere with this interaction may therefore have a clinically significant impact on the ability of N
Externí odkaz:
https://doaj.org/article/3841a4e0b9a54df6b4884810309cd89e
Cellular life relies on enzymes that require metal cofactors, which must be acquired from extracellular sources. Bacteria utilize surface and secreted proteins to acquire such valuable nutrients from their environment. These include the cargo protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0819aa732da215429e1abcb3dd0c983
https://doi.org/10.1101/2023.03.15.532718
https://doi.org/10.1101/2023.03.15.532718
Publikováno v:
Microbiology Australia. 42:116-119
Over the past decade, nontypeable Haemophilus influenzae (NTHi) has gained recognition as a major opportunistic pathogen of the respiratory tract that imposes a substantial global burden of disease, owing to a high rate of morbidity and ensuing compl
Autor:
R Latham, Joel P. Mackay, Brianna Atto, James L. Walshe, Mario Torrado, J. Mitchell Guss, Richard Wilson, Stephen G. Tristram, David A. Gell
Publikováno v:
Molecular Microbiology. 113:381-398
Commensal bacteria serve as an important line of defense against colonisation by opportunisitic pathogens, but the underlying molecular mechanisms remain poorly explored. Here, we show that strains of a commensal bacterium, Haemophilus haemolyticus,
Publikováno v:
Pathogens, Vol 10, Iss 577, p 577 (2021)
Pathogens
Volume 10
Issue 5
Pathogens
Volume 10
Issue 5
Nontypeable Haemophilus influenzae (NTHi) is a major respiratory pathogen that initiates infection by colonising the upper airways. Strategies that interfere with this interaction may therefore have a clinically significant impact on the ability of N
Publikováno v:
Pathogens, Vol 10, Iss 29, p 29 (2021)
Pathogens
Pathogens; Volume 10; Issue 1; Pages: 29
Pathogens
Pathogens; Volume 10; Issue 1; Pages: 29
Nontypeable Haemophilus influenzae (NTHi) is a significant respiratory tract pathogen responsible for infections that collectively pose a substantial health and socioeconomic burden. The clinical course of these infections is largely dictated by NTHi
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract The pivotal role of the tumor microenvironment (TME) in the initiation and advancement of hepatocellular carcinoma (HCC) is widely acknowledged, as it fosters the proliferation and metastasis of HCC cells. Within the intricate TME of HCC, tu
Externí odkaz:
https://doaj.org/article/b3455ecc90204fa38422cb6a7ea2e72c
Autor:
Celine Tohme, Tony Haykal, Ruiqi Yang, Taylor J. Austin, Patricia Loughran, David A. Geller, Richard L. Simmons, Samer Tohme, Hamza O. Yazdani
Publikováno v:
Cells, Vol 13, Iss 17, p 1448 (2024)
Background: Exercise can promote sustainable protection against cold and warm liver ischemia–reperfusion injury (IRI) and tumor metastases. We have shown that this protection is by the induction of hepatic mitochondrial biogenesis pathway. In this
Externí odkaz:
https://doaj.org/article/fb2e62d8e57f457099f6cc270bf554e4
Autor:
Megan, Sjodt, Ramsay, Macdonald, Joanna D, Marshall, Joseph, Clayton, John S, Olson, Martin, Phillips, David A, Gell, Jeff, Wereszczynski, Robert T, Clubb
Publikováno v:
The Journal of biological chemistry. 295(33)
Staphylococcus aureus is a leading cause of life-threatening infections in the United States. It actively acquires the essential nutrient iron from human hemoglobin (Hb) using the iron-regulated surface-determinant (Isd) system. This process is initi