Zobrazeno 1 - 10
of 96
pro vyhledávání: '"David A. Frick"'
Autor:
David A. Frick
In the mid-seventeenth century, Wilno (Vilnius), the second capital of the Polish-Lithuanian Commonwealth, was home to Poles, Lithuanians, Germans, Ruthenians, Jews, and Tatars, who worshiped in Catholic, Uniate, Orthodox, Calvinist, and Lutheran chu
Autor:
Jawad B. Belayet, Sarah Beamish, Mizzanoor Rahaman, Samer Alanani, Rajdeep S. Virdi, David N. Frick, A. F. M. Towheedur Rahman, Joseph S. Ulicki, Sreya Biswas, Leggy A. Arnold, M. S. Rashid Roni, Eric Y. Cheng, Douglas A. Steeber, Karyn M. Frick, M. Mahmun Hossain
Publikováno v:
J Med Chem
Histone acetylation is a prominent epigenetic modification linked to the memory loss symptoms associated with neurodegenerative disease. The use of existing histone deacetylase inhibitor (HDACi) drugs for treatment is precluded by their weak blood–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e52da392db4ac38742625a6dece2af
https://doi.org/10.1021/acs.jmedchem.1c01928
https://doi.org/10.1021/acs.jmedchem.1c01928
Autor:
Nemanja Vuksanovic, Rajdeep S Virdi, Trevor R Melkonian, Robert Bavisotto, Nicholas Hopper, Nicholas R. Silvaggi, David N. Frick
Publikováno v:
Slas Discovery
bioRxiv
bioRxiv
The Mac1 domain of the multifunctional SARS-CoV-2 non-structural protein 3 (nsp3) is a potential COVID-19 drug target because it is suspected to enhance the ability of the virus to evade the human immune system. The SARS-CoV-2 Mac1 domain binds ADP-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79149885fd5d4a061115aef8bb6f5866
http://europepmc.org/articles/PMC7684785
http://europepmc.org/articles/PMC7684785
Autor:
Craig A. Belon, David N. Frick
Publikováno v:
BioTechniques, Vol 45, Iss 4, Pp 433-442 (2008)
A high-throughput, fluorescence-based helicase assay using molecular beacons is described. The assay is tested using the NS3 helicase encoded by the hepatitis C virus (HCV) and is shown to accurately monitor helicase action on both DNA and RNA. In th
Externí odkaz:
https://doaj.org/article/2e0f703d2d054fd19c80fab8adf5941f
Autor:
Paola J S Provazzi, Sourav Mukherjee, Alicia M Hanson, Mauricio L Nogueira, Bruno M Carneiro, David N Frick, Paula Rahal
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144638 (2015)
The hepatitis C virus (HCV) is a species of diverse genotypes that infect over 170 million people worldwide, causing chronic inflammation, cirrhosis and hepatocellular carcinoma. HCV genotype 3a is common in Brazil, and it is associated with a relati
Externí odkaz:
https://doaj.org/article/f94e5349b6d747df892beab02c234f8f
Publikováno v:
Biochemistry
The virus that causes COVID-19, SARS-CoV-2, has a large RNA genome that encodes numerous proteins that might be targets for antiviral drugs. Some of these proteins, such as the RNA-dependent RNA polymerase, helicase, and main protease, are well conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f35ab41298dbe73df3c2a8b81f988aa
http://europepmc.org/articles/PMC7341687
http://europepmc.org/articles/PMC7341687
The virus that causes COVID-19, SARS-CoV-2, has a large RNA genome that encodes numerous proteins that might be targets for antiviral drugs. Some of these proteins, such as the RNA-dependent RNA polymers, helicase and main protease, are well conserve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64214a8f665bded89f8f460a20475879
https://doi.org/10.1101/2020.03.31.014639
https://doi.org/10.1101/2020.03.31.014639
Autor:
David N. Frick
Publikováno v:
Transplant Infectious Disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495d65433cdcc7091668a3c939d4a612
https://doi.org/10.1111/tid.13738
https://doi.org/10.1111/tid.13738
Autor:
David N. Frick, Atreyei Ray
Publikováno v:
Anal Biochem
Nudix proteins are members of a large family of homologous enzymes that hydrolyze nucleoside diphosphates linked to other compounds. The substrates for a subset of Nudix enzymes are all nucleotides linked to RNA, like the m(7)G mRNA caps and the more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d026ec0e724dce0edcc7146d477100
https://doi.org/10.1016/j.ab.2020.113622
https://doi.org/10.1016/j.ab.2020.113622
Publikováno v:
Adv Exp Med Biol
Protein Reviews – Purinergic Receptors ISBN: 9783030143381
Protein Reviews – Purinergic Receptors ISBN: 9783030143381
This review discusses new developments in Forster resonance energy transfer (FRET) microscopy and its application to cellular receptors. The method is based on the kinetic theory of FRET, which can be used to predict FRET not only in dimers, but also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c086382429c17d84aed34d22c30c2754
https://pubmed.ncbi.nlm.nih.gov/30471070
https://pubmed.ncbi.nlm.nih.gov/30471070