Výsledky vyhledávání - "David A. Fraser"

Akademický článek

Icosabutate Exerts Beneficial Effects Upon Insulin Sensitivity, Hepatic Inflammation, Lipotoxicity, and Fibrosis in Mice

Autor: Anita M. van denHoek, Elsbet J. Pieterman, José W. van derHoorn, Marta Iruarrizaga‐Lejarreta, Cristina Alonso, Lars Verschuren, Tore Skjæret, Hans M.G. Princen, David A. Fraser

Publikováno v: Hepatology Communications, Vol 4, Iss 2, Pp 193-207 (2020)

Icosabutate is a structurally engineered eicosapentaenoic acid derivative under development for nonalcoholic steatohepatitis (NASH). In this study, we investigated the absorption and distribution properties of icosabutate in relation to liver targeti

Externí odkaz: https://doaj.org/article/17635485619345adb907554abe0b690f

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Serum 1,25-dihydroxyvitamin D levels in the diagnosis and pathogenesis of nutritional rickets – a multivariable re-analysis of a case-control study

Autor: Philip R. Fischer, Christopher T. Sempos, John M. Pettifor, David R. Fraser, Craig F. Munns, Ramon A. Durazo-Arvizu, Tom D. Thacher

Publikováno v: The American Journal of Clinical Nutrition. 117:998-1004

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6975af7f846d4f4fe53871f72a721e3
https://doi.org/10.1016/j.ajcnut.2023.02.011

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Differences in career paths of alumni of the Cornell Leadership Program from North American universities compared with those alumni from universities in other countries

Autor: David R. Fraser, John S. L. Parker, Douglas D. McGregor

Publikováno v: Journal of the American Veterinary Medical Association. :1-5

OBJECTIVE To characterize and compare the careers of alumni of the Cornell Leadership Program for Veterinary Students according to the countries where they studied and obtained their veterinary qualification. The Cornell Leadership Program is a 10-we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e10dda394ab1ac28ea289f3f411abd5
https://doi.org/10.2460/javma.22.10.0461

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Icosabutate: targeting metabolic and inflammatory pathways for the treatment of NASH

Autor: David A Fraser, Stephen A Harrison, Detlef Schuppan

Publikováno v: Expert opinion on investigational drugs.

Via pleiotropic targeting of membrane and nuclear fatty acid receptors regulating key metabolic and inflammatory pathways in the liver, long-chain omega-3 fatty acids could offer a unique therapeutic approach for the treatment of metabolic-inflammato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ef14220b344218806cda2df0fdf61b
https://pubmed.ncbi.nlm.nih.gov/36527256

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Vitamin D toxicity related to its physiological and unphysiological supply

Autor: David R. Fraser

Publikováno v: Trends in Endocrinology & Metabolism. 32:929-940

Vitamin D is defined as a nutrient despite its rare occurrence in food. Vitamin D status is determined mainly by solar UV light action in skin. However, the strategy to combat vitamin D deficiency has been to increase oral intake of vitamin D in grea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169521ed1b7c615f8f42ff143508272a
https://doi.org/10.1016/j.tem.2021.08.006

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Structurally-engineered fatty acid 1024 (SEFA-1024) improves diet-induced obesity, insulin resistance, and fatty liver disease

Autor: Jordon D. Secor, Bennet S. Cho, Lumeng J. Yu, Amy Pan, Victoria H. Ko, Duy T. Dao, Michael Feigh, Lorenzo Anez‐Bustillos, Gillian L. Fell, David A. Fraser, Kathleen M. Gura, Mark Puder

Publikováno v: Lipids

Obesity is a global epidemic that drives morbidity and mortality through cardiovascular disease, diabetes, and non-alcoholic fatty liver disease (NAFLD). No definitive therapy has been approved to improve glycemic control and treat NAFLD in obese pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abc259ea31d02d93a904e95b9a06ba0
https://europepmc.org/articles/PMC9463121/

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A structurally engineered fatty acid, icosabutate, suppresses liver inflammation and fibrosis in NASH

Autor: David A. Fraser, Xiaoyu Wang, Jenny Lund, Nataša Nikolić, Marta Iruarrizaga-Lejarreta, Tore Skjaeret, Cristina Alonso, John J.P. Kastelein, Arild C. Rustan, Yong Ook Kim, Detlef Schuppan

Publikováno v: Journal of hepatology, 76(4), 800-811. Elsevier

Background & Aims: Although long-chain omega-3 fatty acids (LCn-3FAs) regulate inflammatory pathways of relevance to non-alcoholic steatohepatitis (NASH), their susceptibility to peroxidation may limit their therapeutic potential. We compared the met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bb34640194cc100454542ea670cf9b
https://pure.amc.nl/en/publications/a-structurally-engineered-fatty-acid-icosabutate-suppresses-liver-inflammation-and-fibrosis-in-nash(f9db8dc2-fa29-42cc-b2b8-ea1f1a47881f).html

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USING LIDAR TO IDENTIFY PLANAR MEASUREMENT REGIONS IN ULTRASONIC INSPECTIONS OF COMPLEX STRUCTURES

Autor: IAN T. CUMMINGS, ELENA C. REINISCH, ERICA M. JACOBSON, DAVID H. FRASER, ADAM J. WACHTOR, ERIC B. FLYNN

Publikováno v: Proceedings of the 13th International Workshop on Structural Health Monitoring.

Acoustic Steady State Excitation Spatial Spectroscopy (ASSESS) is an ultrasonic inspection technique that was developed to rapidly evaluate large structures and identify regions of damage. An ultrasonic transducer affixed to the structure emits a sin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38be41ff5155eda8e9e0377230a0532e
https://doi.org/10.12783/shm2021/36318

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