Zobrazeno 1 - 10
of 86
pro vyhledávání: '"David A. Ferrick"'
Autor:
Jakob D. Wikstrom, Samuel B. Sereda, Linsey Stiles, Alvaro Elorza, Emma M. Allister, Andy Neilson, David A. Ferrick, Michael B. Wheeler, Orian S. Shirihai
Publikováno v:
PLoS ONE, Vol 8, Iss 12 (2013)
Externí odkaz:
https://doaj.org/article/fb6faf64026f471396bf06b1b893b94e
Autor:
Brandon R. Desousa, Kristen K.O. Kim, Anthony E. Jones, Andréa B. Ball, Wei Y. Hsieh, Pamela Swain, Danielle H. Morrow, Alexandra J. Brownstein, David A. Ferrick, Orian S. Shirihai, Andrew Neilson, David A. Nathanson, George W. Rogers, Brian P. Dranka, Anne N. Murphy, Charles Affourtit, Steven J. Bensinger, Linsey Stiles, Natalia Romero, Ajit S. Divakaruni
Oxidative phosphorylation and glycolysis are the dominant ATP-generating pathways in mammalian metabolism. The balance between these two pathways is often shifted to execute cell-specific functions in response to stimuli that promote activation, prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::262cd739bb8f66589fce51566c8ae045
https://doi.org/10.1101/2022.04.16.488523
https://doi.org/10.1101/2022.04.16.488523
Autor:
Jakob D Wikstrom, Samuel B Sereda, Linsey Stiles, Alvaro Elorza, Emma M Allister, Andy Neilson, David A Ferrick, Michael B Wheeler, Orian S Shirihai
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e33023 (2012)
The pancreatic beta cell is unique in its response to nutrient by increased fuel oxidation. Recent studies have demonstrated that oxygen consumption rate (OCR) may be a valuable predictor of islet quality and long term nutrient responsiveness. To dat
Externí odkaz:
https://doaj.org/article/113026f2fefc41b1898270645fef0a88
Autor:
George W Rogers, Martin D Brand, Susanna Petrosyan, Deepthi Ashok, Alvaro A Elorza, David A Ferrick, Anne N Murphy
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21746 (2011)
Recently developed technologies have enabled multi-well measurement of O(2) consumption, facilitating the rate of mitochondrial research, particularly regarding the mechanism of action of drugs and proteins that modulate metabolism. Among these techn
Externí odkaz:
https://doaj.org/article/6809df3e6d854ea0b649391d3f2dff26
Autor:
Linsey Stiles, Luciana Berod, Tin Duong, Kacey Caradonna, Ajit S. Divakaruni, Michael J. Wolfgang, Alexsander Y. Andreyev, Tim Sparwasser, Brandon R. Desousa, Daniel Braas, David A. Ferrick, George W. Rogers, Marc Liesa, Theodore P. Ciaraldi, Caitlyn E. Bowman, Lucía Minarrieta, Kristen K.O. Kim, Brian P. Dranka, Steven J. Bensinger, Wei Yuan Hsieh, Anne N. Murphy
Publikováno v:
Cell metabolism, vol 28, iss 3
Long-chain fatty acid (LCFA) oxidation has been shown to play an important role in interleukin-4 (IL-4)-mediated macrophage polarization (M(IL-4)). However, many of these conclusions are based on the inhibition of carnitine palmitoyltransferase-1 wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159495c0d1be78d8c409a5323dfdda36
https://escholarship.org/uc/item/7w98t225
https://escholarship.org/uc/item/7w98t225
Autor:
Steven J. Novick, Julie B. Stimmel, George W. Rogers, David A. Ferrick, James B. Mangum, Kennedy L. Queen, Ruolan Wang
Publikováno v:
SLAS Discovery. 20:422-429
Numerous investigations have linked mitochondrial dysfunction to adverse health outcomes and drug-induced toxicity. The pharmaceutical industry is challenged with identifying mitochondrial liabilities earlier in drug development and thereby reducing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba141130cca7f77b268b7e62ac44cd0d
https://doi.org/10.1177/1087057114557621
https://doi.org/10.1177/1087057114557621
Autor:
Victor M. Darley-Usmar, Brian P. Dranka, Saranya Ravi, Shannon M. Bailey, Robert W. Hardy, David A. Ferrick, Jianhua Zhang, Degui Zhi, Tanecia Mitchell, Scott W. Ballinger, Ashwani K. Singal, Balu K. Chacko, Philip A. Kramer, Gloria A. Benavides
Publikováno v:
Clinical Science (London, England : 1979)
Bioenergetics has become central to our understanding of pathological mechanisms, the development of new therapeutic strategies and as a biomarker for disease progression in neurodegeneration, diabetes, cancer and cardiovascular disease. A key concep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ddf9afbb531579a1898dc1867b77a4d
https://doi.org/10.1042/cs20140101
https://doi.org/10.1042/cs20140101
Autor:
Lina María Ruiz, Alvaro A. Elorza, Claudia A. Riedel, Rodrigo I. Bustos, Ricardo Gutierrez-Garcia, Graciela Argüelloa, Erik Jensen, Claudia Hernández, David A. Ferrick, Mauricio González, Felipe Simon, Rodolfo Paredes
Publikováno v:
Journal of Cellular Physiology. 229:607-619
Copper is an essential cofactor of complex IV of the electron transfer chain, and it is directly involved in the generation of mitochondrial membrane potential. Its deficiency induces the formation of ROS, large mitochondria and anemia. Thus, there i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dc4fdb02d58edaa1db1aaf6313ead95
https://doi.org/10.1002/jcp.24484
https://doi.org/10.1002/jcp.24484
Autor:
Alexander Y. Andreyev, Alejandro P. Heuck, William G. McDonald, Melvin I. Simon, Robert R. Henry, Estelle A. Wall, Theodore P. Ciaraldi, Sandra E. Wiley, Mattias Loviscach, Nagendra Yadava, David A. Ferrick, Ajit S. Divakaruni, Susanna Petrosyan, George W. Rogers, Anne N. Murphy, Jerry R. Colca
Publikováno v:
Proceedings of the National Academy of Sciences. 110:5422-5427
Facilitated pyruvate transport across the mitochondrial inner membrane is a critical step in carbohydrate, amino acid, and lipid metabolism. We report that clinically relevant concentrations of thiazolidinediones (TZDs), a widely used class of insuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba61887b682c43ad1ae60a3af85bdb9
https://doi.org/10.1073/pnas.1303360110
https://doi.org/10.1073/pnas.1303360110
Autor:
Seth T. Rodgers, A. Peter Russo, Brian Benoit, Rachel Legmann, David A. Ferrick, Ronald Fedechko, Ellen L. McCormick, Cynthia L. Deppeler, Sriram Srinivasan, Russell H. Robins
Publikováno v:
Biotechnology Progress. 27:757-765
Top performing clones have failed at the manufacturing scale while the true best performer may have been rejected early in the screening process. Therefore, the ability to screen multiple clones in complex fed-batch processes using multiple process v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48cd0bd24da822aee42a488e641b39a0
https://doi.org/10.1002/btpr.577
https://doi.org/10.1002/btpr.577