Zobrazeno 1 - 7
of 7
pro vyhledávání: '"David A. Fairman"'
Autor:
Akram Khan, Cody Benthin, Brian Zeno, Timothy E. Albertson, John Boyd, Jason D. Christie, Richard Hall, Germain Poirier, Juan J. Ronco, Mark Tidswell, Kelly Hardes, William M. Powley, Tracey J. Wright, Sarah K. Siederer, David A. Fairman, David A. Lipson, Andrew I. Bayliffe, Aili L. Lazaar
Publikováno v:
Critical Care, Vol 21, Iss 1, Pp 1-9 (2017)
Abstract Background Renin-angiotensin system (RAS) signaling and angiotensin-converting enzyme 2 (ACE2) have been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS). We postulated that repleting ACE2 using GSK2586881, a reco
Externí odkaz:
https://doaj.org/article/4b40439005934e0f95c189083cecdc5c
Autor:
James W. T. Yates, David A Fairman
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 3, Pp 588-600 (2022)
Abstract Translational model‐based approaches have played a role in increasing success in the development of novel anticancer treatments. However, despite this, significant translational uncertainty remains from animal models to patients. Optimizat
Externí odkaz:
https://doaj.org/article/81fc557ca8994fe9985f407ffa399e2f
Publikováno v:
Pharmaceutical Research. 39:213-222
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea638f83dd461e12c78b7251b9b03b88
https://doi.org/10.1007/s11095-022-03172-7
https://doi.org/10.1007/s11095-022-03172-7
Autor:
James W. T. Yates, David A Fairman
Publikováno v:
Clinical and Translational Science. 15:588-600
Translational model-based approaches have played a role in increasing success in the development of novel anticancer treatments. However, despite this, significant translational uncertainty remains from animal models to patients. Optimization of dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a21ad56f8e3e16bac091df96ff8d04
https://doi.org/10.1111/cts.13183
https://doi.org/10.1111/cts.13183
Publikováno v:
Pharmaceutical research. 39(2)
The Free Drug Hypothesis is a well-established concept within the scientific lexicon pervading many areas of Drug Discovery and Development, and yet it is poorly defined by virtue of many variations appearing in the literature. Clearly, unbound drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::395e858f0366e1d16b7219d405877d61
https://pubmed.ncbi.nlm.nih.gov/35112229
https://pubmed.ncbi.nlm.nih.gov/35112229
Autor:
Paul A, Glossop, Christine A L, Watson, David A, Price, Mark E, Bunnage, Donald S, Middleton, Anthony, Wood, Kim, James, Dannielle, Roberts, Ross S, Strang, Michael, Yeadon, Christelle, Perros-Huguet, Nicholas P, Clarke, Michael A, Trevethick, Ian, Machin, Emilio F, Stuart, Steven M, Evans, Anthony C, Harrison, David A, Fairman, Balaji, Agoram, Jane L, Burrows, Neil, Feeder, Craig K, Fulton, Barry R, Dillon, David A, Entwistle, Fiona J, Spence
Publikováno v:
Journal of medicinal chemistry. 54(19)
A novel tertiary amine series of potent muscarinic M(3) receptor antagonists are described that exhibit potential as inhaled long-acting bronchodilators for the treatment of chronic obstructive pulmonary disease. Geminal dimethyl functionality presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22c240e08044f99a090aa8ee4d570ee8
https://pubmed.ncbi.nlm.nih.gov/21870878
https://pubmed.ncbi.nlm.nih.gov/21870878
Autor:
David S. Millan, Mark E. Bunnage, Jane L. Burrows, Kenneth J. Butcher, Peter G. Dodd, Timothy J. Evans, David A. Fairman, Samantha J. Hughes, Iain C. Kilty, Arnaud Lemaitre, Russell A. Lewthwaite, Axel Mahnke, John P. Mathias, James Philip, Robert T. Smith, Mark H. Stefaniak, Michael Yeadon, Christopher Phillips
Publikováno v:
Journal of Medicinal Chemistry; Nov2011, Vol. 54 Issue 22, p7797-7814, 18p