Výsledky vyhledávání - "David A. F. Langnel"

Akademický článek

Antitumor imidazotetrazines. 38. New 8-substituted derivatives of the imidazo[5,1-d]-1,2,3,5-tetrazines temozolomide and mitozolomide

Autor: David A. F. Langnel, Jillian Arrowsmith, Malcolm F. G. Stevens

Publikováno v: ARKIVOC, Vol 2000, Iss 3, Pp 421-437 (2000)

Externí odkaz: https://doaj.org/article/21ab0a02507744379c40e1ff37c40a50

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Antitumor imidazotetrazines. 38. New 8-substituted derivatives of the imidazo[5,1-d]-1,2,3,5-tetrazines temozolomide and mitozolomide

Autor: Jillian Arrowsmith, Malcolm F. G. Stevens, David A. F. Langnel

Publikováno v: ARKIVOC, Vol 2000, Iss 3, Pp 421-437 (2000)

The imidazo(5,1-d)-1,2,3,5-tetrazine ring-system is hypersensitive to attack by nucleophiles. Therefore, acidic conditions were applied successfully to synthesise new 8-substituted derivatives of the antitumor agents temozolomide (1a) and mitozolomid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d0592b29c3f3b5dd5fbc17f5512c1f
https://doi.org/10.3998/ark.5550190.0001.324

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Antitumour imidazotetrazines. Part 39. Synthesis of bis(imidazotetrazine)s with saturated spacer groups

Autor: Jill Arrowsmith, Malcolm F. G. Stevens, David A. F. Langnel, Richard T. Wheelhouse, Sharon A. Jennings

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :4432-4438

Bis(imidazotetrazine)s (16), related in structure to the antitumour agents mitozolomide (1a) and temozolomide (1b), but linked through the N(3)–N(3′) atoms of the imidazo[5,1-d][1,2,3,5]tetrazine ring-systems, are prepared by interaction of 5-dia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0cc87a75c5daddae71e64b0cdcb67a28
https://doi.org/10.1039/b005652i

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Antitumour imidazotetrazines. Part 36.1 Conversion of 5-aminoimidazole-4-carboxamide to imidazo[5,1-d ][1,2,3,5]tetrazin-4(3H )-ones and imidazo[1,5-a][1,3,5]triazin-4(3H )-ones related in structure to the antitumour agents temozolomide and mitozolomide

Autor: David A. F. Langnel, Yongfeng Wang, Malcolm F. G. Stevens, Linxiang Zhao, Richard T. Wheelhouse

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :1669-1676

Novel 3-substituted imidazo[5,1-d][1,2,3,5]tetrazinones 3 have been prepared by two routes: reaction of 5-diazoimidazole-4-carboxamide 2 and isocyanates, and nitrosative cyclisation of 5-amino-1-carbamoylimidazole-4-carboxamides 7. The latter cyclisa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5482a811f9b55deee03d74cfb464e51b
https://doi.org/10.1039/a800572i

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ChemInform Abstract: Antitumor Imidazotetrazines. Part 36. Conversion of 5-Aminoimidazole-4-carboxamide to Imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-ones and Imidazo[1,5-a][1,3,5]triazin-4(3H)-ones Related in Structure to the Antitumor Agents Temozolomide and

Autor: Malcolm F. G. Stevens, Richard T. Wheelhouse, Lixia Zhao, Yongfeng Wang, David A. F. Langnel

Publikováno v: ChemInform. 29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b373db6fbb338c27801e1580f22b4e5d
https://doi.org/10.1002/chin.199839183

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ChemInform Abstract: Antitumor Imidazotetrazines. Part 39. Synthesis of Bis(imidazotetrazine)s with Saturated Spacer Groups

Autor: David A. F. Langnel, Jill Arrowsmith, Malcolm F. G. Stevens, Sharon A. Jennings, Richard T. Wheelhouse

Publikováno v: ChemInform. 32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::149cf54d11157826905d699abc570ff8
https://doi.org/10.1002/chin.200120124

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