Zobrazeno 1 - 10
of 15
pro vyhledávání: '"David A. Einfeld"'
Autor:
Cheng Cheng, Gary J. Nabel, Wing Pui Kong, Sung Youl Ko, David A. Einfeld, Jason G. D. Gall, Masaru Kanekiyo, C. Richter King, Lingshu Wang
Publikováno v:
Journal of Virology. 83:748-756
Human immunodeficiency virus type 1 (HIV-1) infection is characterized by the rapid onset of intestinal T-cell depletion that initiates the progression to AIDS. The induction of protective immunity in the intestinal mucosa therefore represents a pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1b51beaac1c4a9df446e682258c246
https://doi.org/10.1128/jvi.01811-08
https://doi.org/10.1128/jvi.01811-08
Autor:
Stephen H. Thorne, Masaki Akiyama, Peter W. Roelvink, C. Richter King, David A. Einfeld, Thomas J. Wickham, David H. Kirn
Publikováno v:
Molecular Therapy. 9:218-230
To create tumor-targeted Ad vectors, ablation of native CAR and integrin receptor binding is crucial to enhance the specificity of tumor transduction. Toward this aim, we have previously created base vectors in which binding to CAR (single-ablated) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f401692e035392f1493f01f17daea75
https://doi.org/10.1016/j.ymthe.2003.10.010
https://doi.org/10.1016/j.ymthe.2003.10.010
Autor:
Thomas J. Wickham, Suchitra Srinivasan, Laura R. Goldberg, Paula R. Clemens, Daniel P. Reay, Tiffany Hughes, Roberto Bilbao, Peter W. Roelvink, David A. Einfeld
Publikováno v:
Human Gene Therapy. 14:645-649
Adenoviral (Ad) infection involves attachment mediated by the Ad fiber protein binding to the coxsackievirus-adenovirus receptor (CAR) of a target cell and internalization facilitated by the interaction of the Ad penton base protein with alpha(v) int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e8d97cd05a3aac9cd0e076dd330bfb
https://doi.org/10.1089/104303403321618155
https://doi.org/10.1089/104303403321618155
Autor:
C. Richter King, Rosanna Schroeder, Alena Lizonova, David A. Einfeld, Peter W. Roelvink, Thomas J. Wickham, Imre Kovesdi
Publikováno v:
Journal of Virology. 75:11284-11291
The development of tissue-selective virus-based vectors requires a better understanding of the role of receptors in gene transfer in vivo, both to rid the vectors of their native tropism and to introduce new specificity. CAR and αv integrins have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a86c1c7da39da81584ea4ac2c50bd3
https://doi.org/10.1128/jvi.75.23.11284-11291.2001
https://doi.org/10.1128/jvi.75.23.11284-11291.2001
Autor:
Wing Pui Kong, C. Richter King, Richard M. Schwartz, David A. Einfeld, Masaru Kanekiyo, Lingshu Wang, Jason G. D. Gall, Sung Youl Ko, Cheng Cheng, Gary J. Nabel
Effective vaccines for human immunodeficiency virus type 1 (HIV-1) will likely need to stimulate protective immunity in the intestinal mucosa, where HIV-1 infection causes severe CD4 + T-cell depletion. While replication-competent recombinant adenovi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0ba65318e807357a2d6dff2d0336d4
https://europepmc.org/articles/PMC2704769/
https://europepmc.org/articles/PMC2704769/
Publikováno v:
International Journal of Oncology.
Ovarian cancer is the fourth most common cancer among women and existing treatment is not routinely curative. One new strategy for cancer therapy is the selective delivery of TNFalpha to tumors via adenovirus vectors. We have tested the combination o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97d539cfe4f35991ed2af635f5506d07
https://doi.org/10.3892/ijo.31.4.813
https://doi.org/10.3892/ijo.31.4.813
Publikováno v:
Molecular Therapy. 13
Ovarian cancer is the fourth most common cancer among women, and despite advances in therapy most patients still die as a consequence of disease that is disseminated within the peritoneal cavity. Delivery of hTNFa gene to tumors using direct intra-tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7296340aa5c610bd219895c74224c29a
Autor:
David A, Einfeld, Peter W, Roelvink
Publikováno v:
Current opinion in molecular therapeutics. 4(5)
Adenovirus-based vectors can efficiently transfer therapeutic genes into cells through an entry process that is initiated be binding to specific receptors on the cell surface. The receptors for the most commonly used Ad vectors include both the Coxsa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::416975155a455886c1d605149206be8e
https://pubmed.ncbi.nlm.nih.gov/12435045
https://pubmed.ncbi.nlm.nih.gov/12435045
The utility of adenovirus as a vector to deliver therapeutic genes would be greatly enhanced if the virus could be specifically targeted to the tissue of interest. Incorporation of tissue-specific ligands into viral coat proteins which lack their nat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3352739e5b636c56d8d2196051fe7be
https://europepmc.org/articles/PMC112945/
https://europepmc.org/articles/PMC112945/
Autor:
David A. Einfeld, Masaki Akiyama, Douglas E. Brough, Selva R. Murugesan, C. Richter King, Thomas J. Wickham, Jason G. Gall
Publikováno v:
Molecular Therapy. 11:S392
Generation of tropism modified adenovirus vectors with improved pharmacokinetics and bioavailability is likely to be critical for their application to the treatment of disseminated cancer. The goal of our studies is to identify strategies that enhanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54f4b10529058173019c15d324ee7571
https://doi.org/10.1016/j.ymthe.2005.07.560
https://doi.org/10.1016/j.ymthe.2005.07.560