Výsledky vyhledávání - "David A. Eavarone"

Akademický článek

Humanized anti-Sialyl-Tn antibodies for the treatment of ovarian carcinoma.

Autor: David A Eavarone, Linah Al-Alem, Alexey Lugovskoy, Jillian M Prendergast, Rawan I Nazer, Jenna N Stein, Daniel T Dransfield, Jeff Behrens, Bo R Rueda

Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0201314 (2018)

The expression of Sialyl-Tn (STn) in tumors is associated with metastatic disease, poor prognosis, and reduced overall survival. STn is expressed on ovarian cancer biomarkers including CA-125 (MUC16) and MUC1, and elevated serum levels of STn in ovar

Externí odkaz: https://doaj.org/article/1ed3cf5163d54450925d78f8a05687dc

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Treatment of ovarian cancer by targeting the tumor stem cell-associated carbohydrate antigen, Sialyl-Thomsen-nouveau

Autor: David A. Eavarone, Linah Al-Alem, Bianca Zarrella, Kristen D. Starbuck, Bo R. Rueda, Whitfield B. Growdon, Rosemary Foster, Daniel T Dransfield, Chiara Bellio, Silvia F. Hernandez, Jillian M. Prendergast, Jenna Stein, Jeff Behrens

Publikováno v: Oncotarget

Recurrent ovarian cancer (OvCa) is thought to result in part from the inability to eliminate rare quiescent cancer stem cells (CSCs) that survive cytotoxic chemotherapy and drive tumor resurgence. The Sialyl-Thomsen-nouveau antigen (STn) is a carbohy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b114f0ea5be1313b8d6814d0a37f63a
https://doi.org/10.18632/oncotarget.25289

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Novel anti-Sialyl-Tn monoclonal antibodies and antibody-drug conjugates demonstrate tumor specificity and anti-tumor activity

Autor: Bo R. Rueda, Jillian M. Prendergast, David A. Eavarone, Jeff Behrens, Julie DeSander, Joan Wicks, Dane A. Brady, Mai Zhang, Darius Ghaderi, Ana Paula Galvao da Silva

Publikováno v: mAbs

Targeted therapeutics that can differentiate between normal and malignant tumor cells represent the ideal standard for the development of a successful anti-cancer strategy. The Sialyl-Thomsen-nouveau antigen (STn or Sialyl-Tn, also known as CD175s) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfadaea5022b508c694df898fee535af
https://doi.org/10.1080/19420862.2017.1290752

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Abstract B28: Targeting the tumor-associated carbohydrate antigen STn with humanized anti-Sialyl-Tn monoclonal antibody-drug conjugates inhibits ovarian cancer tumor growth in vitro and in vivo

Autor: Linah Al-Alem, Rawan Nazer, Jillian M. Prendergast, Bo R. Rueda, Daniel T. Dransfield, Jenna Stein, David A. Eavarone, Jeff Behrens

Publikováno v: Clinical Cancer Research. 24:B28-B28

Ovarian cancer is the leading cause of death from gynecologic malignancies in the U.S. The current standard of care is tumor debulking followed by chemotherapy. This treatment results in approximately 70% of patients achieving an initial complete cli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27595062fc5ea583d6ee4b26ed25dabf
https://doi.org/10.1158/1557-3265.ovca17-b28

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Humanized anti-Sialyl-Tn antibodies for the treatment of ovarian carcinoma

Autor: Jillian M. Prendergast, David A. Eavarone, Rawan Nazer, Bo R. Rueda, Jenna Stein, Jeff Behrens, Linah Al-Alem, Daniel T Dransfield, Alexey Alexandrovich Lugovskoy

Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0201314 (2018)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee1986b669bb80313d6fc64254e783c
https://doi.org/10.1371/journal.pone.0201314

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Abstract 5625: Myeloid derived suppressor cells (MDSCs) express Sialyl Tn (STn) and are a therapeutic target for anti-STn antibody drug conjugates

Autor: Daniel T. Dransfield, Adam Curtis, Patricia E. Rao, Rong Zhang, Jenna Stein, David A. Eavarone, Lindsay S. Shopland, Jeff Behrens, Jillian M. Prendergast

Publikováno v: Cancer Research. 78:5625-5625

Introduction: Myeloid derived suppressor cells (MDSCs) are functionally defined by their capacity to suppress T cell immunity; therefore inhibiting these cells is of great interest for immuno-oncology applications. STn, the sialylated version of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3a30eaa802efa5e129942e790e9c3cd
https://doi.org/10.1158/1538-7445.am2018-5625

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Abstract B114: Humanized anti-Sialyl-Tn monoclonal antibody-drug conjugates inhibit tumor growth in vitro and in vivo

Autor: Jillian M. Prendergast, Daniel T. Dransfield, Bo R. Rueda, Jenna Stein, Jeff Behrens, Rawan Nazer, Linah Al-Alem, David A. Eavarone

Publikováno v: Molecular Cancer Therapeutics. 17:B114-B114

Targeted therapeutics that can differentiate between normal and malignant tumor cells represent the ideal standard for the development of a successful anticancer strategy. The Sialyl-Thomsen-nouveau antigen (STn or Sialyl-Tn, also known as CD175s) is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1f13f73c77dcce89cb9892a3aa46432
https://doi.org/10.1158/1535-7163.targ-17-b114

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Glycome and Transcriptome Regulation of Vasculogenesis

Autor: Ram Sasisekharan, Cristin G. Print, David A. Eavarone, Shiladitya Sengupta, Tanyel Kiziltepe, Stephanie Piecewicz, Sudipta Basu, Dirk M. Hentschel, Rania Harfouche

Publikováno v: PMC

Background— Therapeutic vasculogenesis is an emerging concept that can potentially be harnessed for the management of ischemic pathologies. The present study elucidates the potential coregulation of vasculogenesis by the heparan sulfate glycosamino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97498b24a0c2e6ca9d10930ce1f3cf30
https://doi.org/10.1161/circulationaha.108.837724

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Abstract 36: Novel anti-Sialyl-Tn monoclonal antibodies and antibody-drug conjugates (ADCs) demonstrate tumor specificity in vitro and in vivo antitumor efficacy

Autor: David A. Eavarone, Todd A. Hoffert, Lindsay S. Shopland, Adam Curtis, Jillian M. Prendergast, Jeff Behrens, Jenna Stein, Daniel T. Dransfield, Patricia E. Rao

Publikováno v: Cancer Research. 77:36-36

Tumor-associated carbohydrate antigens (TACAs) historically have been challenging targets for antibody therapeutics. Sialyl-Tn (STn) is a cancer specific antigen that is expressed on the cell surface of carcinomas including ovarian, colon, prostate,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b92622a3e5d75b1aa1749c3ff6bc4f0f
https://doi.org/10.1158/1538-7445.am2017-36

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Abstract 3640: Novel humanized anti-Sialyl-Tn, anti-CD3 bispecific antibodies demonstrate tumor and T-cell specificity for immune activation at the tumor site

Autor: Jenna Stein, Jillian M. Prendergast, Daniel T. Dransfield, Patricia E. Rao, David A. Eavarone, Jeff Behrens

Publikováno v: Cancer Research. 77:3640-3640

Tumor-associated carbohydrate antigens (TACAs) historically have been challenging targets for antibody therapeutics. Sialyl-Tn (STn) is a cancer specific antigen that is expressed on the surface of carcinomas including ovarian, colon, prostate, and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65e1e7e786e64b021e2aff3283181e58
https://doi.org/10.1158/1538-7445.am2017-3640

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