Zobrazeno 1 - 10
of 131
pro vyhledávání: '"David A. D'Argenio"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The aim of this study was to develop a dynamic model-based approach to separately quantify the exogenous and endogenous contributions to total plasma insulin concentration and to apply it to assess the effects of inhaled-insulin administrati
Externí odkaz:
https://doaj.org/article/996d6dde823e49adacb9410f7e77c09b
Publikováno v:
Journal of NeuroEngineering and Rehabilitation, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Background Given the heterogeneity of stroke, it is important to determine the best course of motor therapy for each patient, i.e., to personalize rehabilitation based on predictions of long-term outcomes. Here, we propose a hierarchical Bay
Externí odkaz:
https://doaj.org/article/9294d77c794440eb9eeac405b2aa19b4
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/4d032b2f4a5340a1a1ca1152a8f435f8
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
A model-based framework is presented to predict monoclonal antibody (mAb) pharmacokinetics (PK) in humans based on in vitro measures of antibody physiochemical properties. A physiologically based pharmacokinetic (PBPK) model is used to explore the pr
Externí odkaz:
https://doaj.org/article/d38c4c49ffa248d5b8813a33df7d09fe
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 7, Pp 671-683 (2021)
Abstract A circulatory model of granulopoiesis and its regulation is presented that includes neutrophil trafficking in the lungs, liver, spleen, bone marrow, lymph nodes, and blood. In each organ, neutrophils undergo transendothelial migration from v
Externí odkaz:
https://doaj.org/article/bf5aef639c6f4750b6e6b96bdcef4b35
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Glucose effectiveness, defined as the ability of glucose itself to increase glucose utilization and inhibit hepatic glucose production, is an important mechanism maintaining normoglycemia. We conducted a minimal modeling analysis of glucose effective
Externí odkaz:
https://doaj.org/article/07da6829b353488c94234b48a5f60762
Publikováno v:
Membranes, Vol 11, Iss 5, p 331 (2021)
Primary rat alveolar epithelial cell monolayers (RAECM) were grown without (type I cell-like phenotype, RAECM-I) or with (type II cell-like phenotype, RAECM-II) keratinocyte growth factor to assess passive transport of 11 hydrophilic solutes. We esti
Externí odkaz:
https://doaj.org/article/1bdd124a3d684f3e8a9500e6f3141bc4
Publikováno v:
The AAPS Journal. 25
An integrated physiologically based modeling framework is presented for predicting pharmacokinetics and bioavailability of subcutaneously administered monoclonal antibodies in cynomolgus monkeys, based on in silico structure-derived metrics character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9574c3cc7a3c439523b643a7c83a15a2
https://doi.org/10.1208/s12248-022-00772-4
https://doi.org/10.1208/s12248-022-00772-4
BackgroundGiven the heterogeneity of stroke, it is important to determine the best course of motor therapy for each patient, i.e., to personalize rehabilitation based on predictions of long-term outcomes. Here, we propose a Hierarchical Bayesian dyna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fb18e6c19e959012c40cdbed0e69a89
https://doi.org/10.1101/2022.10.20.22280926
https://doi.org/10.1101/2022.10.20.22280926
Publikováno v:
Pharmaceutical research. 39(12)
Purpose In order to clarify the effect of rifampicin on the bioavailability of the P-glycoprotein substrate talinolol, its absorption kinetics was modeled after multiple-dose oral administration of talinolol in healthy subjects. Methods A sum of two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f8d51c8a37803971afd5df9ec65aa3
https://pubmed.ncbi.nlm.nih.gov/36163409
https://pubmed.ncbi.nlm.nih.gov/36163409