Zobrazeno 1 - 10
of 52
pro vyhledávání: '"David A. Crispin"'
Autor:
Kay L Pogue-Geile, Ru Chen, Mary P Bronner, Tatjana Crnogorac-Jurcevic, Kara White Moyes, Sally Dowen, Carol A Otey, David A Crispin, Ryan D George, David C Whitcomb, Teresa A Brentnall
Publikováno v:
PLoS Medicine, Vol 3, Iss 12, p e516 (2006)
BackgroundPancreatic cancer is a deadly disease. Discovery of the mutated genes that cause the inherited form(s) of the disease may shed light on the mechanism(s) of oncogenesis. Previously we isolated a susceptibility locus for familial pancreatic c
Externí odkaz:
https://doaj.org/article/65aaf5c116f849e1973ffad1e2090847
Autor:
Nolan G. Ericson, Nathan Basisty, Vivian L. MacKay, Dao-Fu Dai, Edward J. Hsieh, Jason H. Bielas, David A. Crispin, Pabalu P. Karunadharma, Michael J. MacCoss, Ying A. Chiao, Richard P. Beyer, Peter S. Rabinovitch, Ellen Quarles
Publikováno v:
Aging Cell
Calorie restriction (CR) and rapamycin (RP) extend lifespan and improve health across model organisms. Both treatments inhibit mammalian target of rapamycin (mTOR) signaling, a conserved longevity pathway and a key regulator of protein homeostasis, y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e9639cbc4def019c1e2ccfcd1a54ed
https://doi.org/10.1111/acel.12317
https://doi.org/10.1111/acel.12317
Autor:
K. Lachance, Paul Nghiem, David M. Koelle, Matthew Fitzgibbon, Gerald Willimsky, Martin W. McIntosh, Candice D. Church, Natalie J. Miller, Ioannis Gavvovidis, Thomas Blankenstein, Michi M. Shinohara, Lichen Jing, David A. Crispin, Lichun Dong
Tumor-infiltrating CD8+ T cells are associated with improved survival of patients with Merkel cell carcinoma (MCC), an aggressive skin cancer causally linked to Merkel cell polyomavirus (MCPyV). However, CD8+ T-cell infiltration is robust in only 4%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1f27fdac3f2e69d404f1931d398a37
https://europepmc.org/articles/PMC5421625/
https://europepmc.org/articles/PMC5421625/
Autor:
Wei Zhao, Martin W. McIntosh, Matthew Fitzgibbon, Nigel Clegg, Gordon B. Mills, David A. Crispin, Lindsay Bergan
RNA-seq and mass-spectrometry proteomics combined with growing data repositories have greatly increased the capacity to identify candidate proteins or protein sequence variants that share properties of ideal therapy targets, which include being abund
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6901e85913bfda37ce74935d5736de42
https://europepmc.org/articles/PMC5839124/
https://europepmc.org/articles/PMC5839124/
Autor:
Haiwei Gu, Michael J. MacCoss, Danijel Djukovic, Nathan Basisty, David A. Crispin, Pabalu P. Karunadharma, Daniel Raftery, Peter S. Rabinovitch, Edward J. Hsieh, Tony Chen, Richard P. Beyer, Dao-Fu Dai, Ying A. Chiao
Publikováno v:
Aging Cell
Chronic caloric restriction (CR) and rapamycin inhibit the mechanistic target of rapamycin (mTOR) signaling, thereby regulating metabolism and suppressing protein synthesis. Caloric restriction or rapamycin extends murine lifespan and ameliorates man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c1fcaf7f9f0cfb0737ffd926304fb5
https://doi.org/10.1111/acel.12203
https://doi.org/10.1111/acel.12203
Autor:
Jesse J. Salk, Peter S. Rabinovitch, David A. Crispin, Cigdem Himmetoglu Ussakli, Lisa A. Lai, Lawrence A. Loeb, Rosa Ana Risques, Aasthaa Bansal, Teresa A. Brentnall, Marshall S. Horwitz, Mary P. Bronner
Publikováno v:
Inflammatory Bowel Diseases. 19:2593-2602
Background: Patients with ulcerative colitis (UC) are at risk of developing colorectal cancer. We have previously reported that cancer progression is associated with the presence of clonal expansions and shorter telomeres in nondysplastic mucosa. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e0ac10513182ebcbc6136bd6b6744f
https://doi.org/10.1097/mib.0b013e3182a87640
https://doi.org/10.1097/mib.0b013e3182a87640
Autor:
Argyrios Ziogas, Sheng Pan, Mary P. Bronner, Martin W. McIntosh, Teresa A. Brentnall, Damon May, Hoda Anton-Culver, Ru Chen, Tyler Stevens, David A. Crispin
Publikováno v:
Journal of Proteome Research. 10:2359-2376
Pancreatic cancer is a lethal disease that is difficult to diagnose at early stages when curable treatments are effective. Biomarkers that can improve current pancreatic cancer detection would have great value in improving patient management and surv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b705672492b952071d393be95000544
https://doi.org/10.1021/pr101148r
https://doi.org/10.1021/pr101148r
Autor:
Raymond R. Tubbs, David A. Crispin, Mary P. Bronner, Marek Skacel, Lisa A. Lai, Peter D. Hoff, Jacintha O'Sullivan, Teresa A. Brentnall, Mary J. Emond, Peter S. Rabinovitch
Publikováno v:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Approximately 10% of ulcerative colitis patients develop colorectal neoplasia. At present, identification of this subset is markedly limited and necessitates lifelong colonoscopic surveillance for the entire ulcerative colitis population. Better risk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db34f658fb8637a1b4bc47d93ee7072d
https://doi.org/10.1038/modpathol.2010.161
https://doi.org/10.1038/modpathol.2010.161
Autor:
Marshall S. Horwitz, Peter S. Rabinovitch, Lin Li, Jesse J. Salk, Teresa A. Brentnall, Mary P. Bronner, Rosa Ana Risques, Lawrence A. Loeb, Stephen J. Salipante, David A. Crispin
Publikováno v:
Proceedings of the National Academy of Sciences. 106:20871-20876
Chronic inflammation predisposes to a variety of human cancers. Affected tissues slowly accumulate mutations, some of which affect growth regulation and drive successive waves of clonal evolution, whereas a far greater number are functionally neutral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab07fb33db7da80e4f12ed584261d2cd
https://doi.org/10.1073/pnas.0909428106
https://doi.org/10.1073/pnas.0909428106
Autor:
Joshua F. Coleman, Hamid Mirzaei, Martin W. McIntosh, Mary P. Bronner, Kelly Cooke, Zhaoli Lane, David A. Crispin, David R. Goodlett, Beth Ann Reimel, William Traverso, Sheng Pan, Ru Chen, Ruedi Aebersold, Teresa A. Brentnall
Publikováno v:
ELECTROPHORESIS. 30:1132-1144
Patients with pancreatic cancer are usually diagnosed at late stages, when the disease is incurable. Pancreatic intraepithelial neoplasia (PanIN) 3 is believed to be the immediate precursor lesion of pancreatic adenocarcinoma, and would be an ideal s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce3792c998c7a5964d77c0b97cc4abc
https://doi.org/10.1002/elps.200800752
https://doi.org/10.1002/elps.200800752