Zobrazeno 1 - 10
of 154
pro vyhledávání: '"David A. Colby"'
Publikováno v:
Journal of Chemical Information and Modeling. 63:375-386
Autor:
Hari R, Khatri, Changho, Han, Reem A, Alkhodier, Amna T, Adam, Baharul, Islam, David A, Colby
Publikováno v:
Chem Commun (Camb)
A method for the in situ production of formaldehyde from dimethylsulfoxide, bromine, and cesium carbonate is reported for reactions with difluoroenolates and difluorobenzyl carbanions. This process also generates formaldehyde-d(2) for the production
Publikováno v:
Chemical Communications. 58:5490-5493
A method for the in situ production of formaldehyde from dimethylsulfoxide, bromine, and cesium carbonate is reported for reactions with difluoroenolates and difluorobenzyl carbanions.
Autor:
Hilda Mirbaha, Dailu Chen, Olga A Morazova, Kiersten M Ruff, Apurwa M Sharma, Xiaohua Liu, Mohammad Goodarzi, Rohit V Pappu, David W Colby, Hamid Mirzaei, Lukasz A Joachimiak, Marc I Diamond
Publikováno v:
eLife, Vol 7 (2018)
Tauopathies feature progressive accumulation of tau amyloids. Pathology may begin when these amplify from a protein template, or seed, whose structure is unknown. We have purified and characterized distinct forms of tau monomer—inert (Mi) and seed-
Externí odkaz:
https://doaj.org/article/4a281ab9d29a4287a093526308f4f1c5
Autor:
Bei Wu, Alex J McDonald, Kathleen Markham, Celeste B Rich, Kyle P McHugh, Jörg Tatzelt, David W Colby, Glenn L Millhauser, David A Harris
Publikováno v:
eLife, Vol 6 (2017)
PrPC, the cellular isoform of the prion protein, serves to transduce the neurotoxic effects of PrPSc, the infectious isoform, but how this occurs is mysterious. Here, using a combination of electrophysiological, cellular, and biophysical techniques,
Externí odkaz:
https://doaj.org/article/e25aea8ab81e414abac02e864afe08be
Publikováno v:
Org Lett
α-Haloketones are valuable intermediates in the synthesis of pharmaceuticals and natural products because they display two electrophiles. Although chemoselective additions to each of these functional groups are known, the use of fluorinated nucleoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e8d1b99359d6aa3e5452eea7961968
https://europepmc.org/articles/PMC8764867/
https://europepmc.org/articles/PMC8764867/
Publikováno v:
Bioorg Med Chem Lett
Flavones are valuable scaffolds in medicinal chemistry, especially as they display activity as antioxidants and neuroprotective agents. The need to incorporate a fluorine atom on flavones has driven much of the recent synthetic work in this area. We
Publikováno v:
Org Lett
Fluoroalkenes serve as bioisosteres to peptide bonds and are resistant to hydrolytic enzymes in vivo. Currently, α-fluoro-α,β-unsaturated carbonyl compounds are readily accessible via general synthetic methods; however, β-fluoro-α,β-unsaturated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245459f5a80b9f76515209a0aa0c9c23
https://europepmc.org/articles/PMC7465497/
https://europepmc.org/articles/PMC7465497/