Výsledky vyhledávání - "David A. Close"

Akademický článek

Characterization of allosteric modulators that disrupt androgen receptor co-activator protein-protein interactions to alter transactivation–Drug leads for metastatic castration resistant prostate cancer

Autor: Ashley T. Fancher, Yun Hua, David A. Close, Wei Xu, Lee A. McDermott, Christopher J. Strock, Ulises Santiago, Carlos J. Camacho, Paul A. Johnston

Publikováno v: SLAS Discovery, Vol 28, Iss 7, Pp 325-343 (2023)

Three series of compounds were prioritized from a high content screening campaign that identified molecules that blocked dihydrotestosterone (DHT) induced formation of Androgen Receptor (AR) protein-protein interactions (PPIs) with the Transcriptiona

Externí odkaz: https://doaj.org/article/1f522784d4774c6bb7d40f6419a475d6

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Akademický článek

Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines

Autor: David A. Close, Paul A. Johnston

Publikováno v: SLAS Discovery, Vol 27, Iss 1, Pp 39-54 (2022)

In solid tumors like head and neck cancer (HNC), chronic and acute hypoxia have serious adverse clinical consequences including poorer overall patient prognosis, enhanced metastasis, increased genomic instability, and resistance to radiation-, chemo-

Externí odkaz: https://doaj.org/article/e971a5d9dc9d46819f246bd958154abf

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Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines

Autor: Paul A. Johnston, David A Close

Publikováno v: SLAS Discovery. 27:39-54

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f22ad1eaabc077aff4f7de9ff8e06c
https://doi.org/10.1016/j.slasd.2021.10.008

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Unbiased High-Throughput Drug Combination Pilot Screening Identifies Synergistic Drug Combinations Effective against Patient-Derived and Drug-Resistant Melanoma Cell Lines

Autor: Walter J. Storkus, Ronald J Fecek, John M. Kirkwood, Paul A. Johnston, David A Close

Publikováno v: SLAS Discov

We describe the development, optimization, and validation of 384-well growth inhibition assays for six patient-derived melanoma cell lines (PDMCLs), three wild type (WT) for BRAF and three with V600E-BRAF mutations. We conducted a pilot drug combinat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed36b9a611ae3bf321c140a77512548f
https://doi.org/10.1177/2472555220970917

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Akademický článek

Projected Scenarios for Coastal First Nations' Fisheries Catch Potential under Climate Change: Management Challenges and Opportunities.

Autor: Lauren V Weatherdon, Yoshitaka Ota, Miranda C Jones, David A Close, William W L Cheung

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0145285 (2016)

Studies have demonstrated ways in which climate-related shifts in the distributions and relative abundances of marine species are expected to alter the dynamics and catch potential of global fisheries. While these studies assess impacts on large-scal

Externí odkaz: https://doaj.org/article/851575424358413db36fdcc2e211d268

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One-electron oxidation of ds(5′-GGG-3′) and ds(5′-G(8OG)G-3′) and the nature of hole distribution: a density functional theory (DFT) study

Autor: Michael D. Sevilla, Anil Kumar, David M. Close, Amitava Adhikary

Publikováno v: Phys Chem Chem Phys

Of particular interest in radiation-induced charge transfer processes in DNA is the extent of hole localization immediately after ionization and subsequent relaxation. To address this, we considered double stranded oligomers containing guanine (G) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de1a016b371cd849bb5851ba17abc60
https://doi.org/10.1039/c9cp06244k

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Confirmation of Selected Synergistic Cancer Drug Combinations Identified in an HTS Campaign and Exploration of Drug Efflux Transporter Contributions to the Mode of Synergy

Autor: Paul A. Johnston, Stanton J Kochanek, Julie L. Eiseman, Tongying Shun, Allen Xinwei Wang, David A Close, Philip E. Empey

Publikováno v: SLAS Discovery. 24:653-668

Systematic unbiased high-throughput screening (HTS) of drug combinations (DCs) in well-characterized tumor cell lines is a data-driven strategy to identify novel DCs with potential to be developed into effective therapies. Four DCs from a DC HTS camp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a341cbca337474824667c48ec9b8746a
https://doi.org/10.1177/2472555219844566

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High Content Screening Characterization of Head and Neck Squamous Cell Carcinoma Multicellular Tumor Spheroid Cultures Generated in 384-Well Ultra-Low Attachment Plates to Screen for Better Cancer Drug Leads

Autor: Paul A. Johnston, Stanton J Kochanek, David A Close

Publikováno v: ASSAY and Drug Development Technologies. 17:17-36

Multicellular tumor spheroid (MCTS) cultures represent more physiologically relevant in vitro cell tumor models that recapitulate the microenvironments and cell–cell or cell–extracellular matrix interactions which occur in solid tumors. We charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e89fa17288ff141b686d31b390427fb
https://doi.org/10.1089/adt.2018.896

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