Zobrazeno 1 - 10
of 517
pro vyhledávání: '"David A. Church"'
Publikováno v:
Frontiers in Nutrition, Vol 11 (2024)
The quality of a dietary protein refers to its ability to provide the EAAs necessary to meet dietary requirements. There are 9 dietary amino acids that cannot be metabolically produced in the body and therefore must be consumed as part of the diet to
Externí odkaz:
https://doaj.org/article/18e9901a0ebe4594a2abf1bdb781a1db
Autor:
Marta Nowak, Faiz Jabbar, Ann-Katrin Rodewald, Luciana Gneo, Tijana Tomasevic, Andrea Harkin, Tim Iveson, Mark Saunders, Rachel Kerr, Karin Oein, Noori Maka, Jennifer Hay, Joanne Edwards, Ian Tomlinson, Owen Sansom, Caroline Kelly, Francesco Pezzella, David Kerr, Alistair Easton, Enric Domingo, Viktor H. Koelzer, David N. Church, Bengt Glimelius, Ismail Gogenur, Emma Jaeger, Hannah Morgan, Clare Orange, Claire Palles, Campbell Roxburgh
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101727- (2024)
Summary: Testing for DNA mismatch repair deficiency (MMRd) is recommended for all colorectal cancers (CRCs). Automating this would enable precision medicine, particularly if providing information on etiology not captured by deep learning (DL) methods
Externí odkaz:
https://doaj.org/article/0addef455aaa46a896ad776bd6ad5c75
Autor:
Gareth Evans, Tjalling Bosse, David N Church, Noel de Miranda, James Bolton, Neil Ryan, Emma Crosbie, Thomas Walker, Marieke Ijsselsteijn, Mark Glaire, Natalja ter Haar
Publikováno v:
BMJ Oncology, Vol 3, Iss 1 (2024)
Objective To explore the impact of molecular subtype in endometrial cancer (EC) on CD8+T cell densities. Furthermore, this work will test the assumption that all mismatch repair deficient (MMRd) tumours are immunologically similar which would enable
Externí odkaz:
https://doaj.org/article/0d7d9326c85c4ec0a50f47499e3953a4
Publikováno v:
Canine Medicine and Genetics, Vol 11, Iss 1, Pp 1-16 (2024)
Abstract Background Shih Tzus are a popular dog breed in the UK although there is relatively little reported information on their health. This study aimed to characterise the demography, common disorders and mortality of Shih Tzus under primary veter
Externí odkaz:
https://doaj.org/article/657d6c33d0c3436bb75e64d9ee6250eb
Publikováno v:
Canine Medicine and Genetics, Vol 11, Iss 1, Pp 1-13 (2024)
Abstract Background The English Cocker Spaniel (ECS) is one of the most popular dog breeds in the UK but information on disorder predisposition and protection is limited. Using anonymised veterinary clinical data from the VetCompass™ Programme, thi
Externí odkaz:
https://doaj.org/article/83bc81bba74e42f794022c1ebd9991a2
Autor:
Dan G. O’Neill, Karolina S. Engdahl, Alice Leach, Rowena M. A. Packer, David B. Church, Dave C. Brodbelt
Publikováno v:
Canine Medicine and Genetics, Vol 10, Iss 1, Pp 1-14 (2023)
Abstract Background The Shar Pei is a common dog breed with a distinctive appearance caused by hyaluronosis that has been linked with several health conditions. Anonymised primary-care veterinary clinical records were explored to extract data on the
Externí odkaz:
https://doaj.org/article/179e555826cb47b7ab34863594bc8204
Publikováno v:
Frontiers in Nutrition, Vol 11 (2024)
Essential amino acid (EAA)-based compositions have been shown to be effective stimulators of muscle protein synthesis, but the lower limit of effective dosage is not clear. We have used stable isotope tracer methodology to quantify the response of mu
Externí odkaz:
https://doaj.org/article/47efe54eef6444488ddec0d58476cfb5
Autor:
Anja L Frei, Anthony McGuigan, Ritik RAK Sinha, Mark A Glaire, Faiz Jabbar, Luciana Gneo, Tijana Tomasevic, Andrea Harkin, Tim J Iveson, Mark Saunders, Karin Oein, Noori Maka, Francesco Pezella, Leticia Campo, Jennifer Hay, Joanne Edwards, Owen J Sansom, Caroline Kelly, Ian Tomlinson, Wanja Kildal, Rachel S Kerr, David J Kerr, Håvard E Danielsen, Enric Domingo, TransSCOT Consortium, David N Church, Viktor H Koelzer
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 6, Pp 449-463 (2023)
Abstract Multiplex immunofluorescence (mIF) imaging can provide comprehensive quantitative and spatial information for multiple immune markers for tumour immunoprofiling. However, application at scale to clinical trial samples sourced from multiple i
Externí odkaz:
https://doaj.org/article/d2fd350d290249e6b38f3b09f966ff54
Autor:
David D. Church, Katie R. Hirsch, Shiloah A. Kviatkovsky, Arny A. Ferrando, Gohar Azhar, Robert R Wolfe
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 130-131 (2024)
OBJECTIVES/GOALS: We endeavor to investigated the hypothesis that muscle protein synthesis (MPS) is stimulated more after consumption of a 4-ounce beef patty as compared to 4- and 8-ounces of a soy protein based meat alternative (SPBMA) and if a grea
Externí odkaz:
https://doaj.org/article/11631792a07f47de9a149377730e347e
Autor:
Dan G. O’Neill, Grace L. Edmunds, Jade Urquhart-Gilmore, David B. Church, Lynda Rutherford, Matthew J. Smalley, Dave C. Brodbelt
Publikováno v:
Canine Medicine and Genetics, Vol 10, Iss 1, Pp 1-17 (2023)
Abstract Background Osteosarcoma is a malignant bone neoplasia that has high welfare consequences for affected dogs. Awareness of breed and canine conformational risk factors for osteosarcoma can assist with earlier diagnosis and improved clinical ma
Externí odkaz:
https://doaj.org/article/ee3bcf2179c64d919995ec59d8bca5ef