Zobrazeno 1 - 10
of 521
pro vyhledávání: '"David A. Case"'
Publikováno v:
ACS Omega, Vol 9, Iss 27, Pp 29682-29690 (2024)
Externí odkaz:
https://doaj.org/article/ed08964a04bd428faeb59503cc527f4c
Autor:
Ainan Geng, Laura Ganser, Rohit Roy, Honglue Shi, Supriya Pratihar, David A. Case, Hashim M. Al-Hashimi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Sparse and short-lived excited RNA conformational states are essential players in cell physiology, disease, and therapeutic development, yet determining their 3D structures remains challenging. Combining mutagenesis, NMR spectroscopy, and co
Externí odkaz:
https://doaj.org/article/19d0e5c055614e97812f937259ec0244
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
X-ray diffraction images contain a signal that is an untapped source of information on protein dynamics. Here, the authors lay out a general workflow for interpreting this diffuse scattering signal and expanding the capabilities of protein crystallog
Externí odkaz:
https://doaj.org/article/62b86a7412104ea1ae450dda3d429bda
Autor:
Bei Liu, Honglue Shi, Atul Rangadurai, Felix Nussbaumer, Chia-Chieh Chu, Kevin Andreas Erharter, David A. Case, Christoph Kreutz, Hashim M. Al-Hashimi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
m6A RNA post-transcriptional modification changes RNA hybridization kinetics. Here the authors show that the methylamino group can adopt syn-conformation pairing with uridine with a mismatch-like conformation in RNA duplex. They also develop a quanti
Externí odkaz:
https://doaj.org/article/82625506d090481bad2beca7aff5481e
Autor:
Honglue Shi, Atul Rangadurai, Hala Abou Assi, Rohit Roy, David A. Case, Daniel Herschlag, Joseph D. Yesselman, Hashim M. Al-Hashimi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Determining dynamic ensembles of biomolecules is still challenging. Here the authors present an approach for rapid RNA ensemble determination that combines RNA structure prediction tools and NMR residual dipolar coupling data and use it to determine
Externí odkaz:
https://doaj.org/article/6aa8fe55c63a47b68b968427d832dae8
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Protein motion in crystals causes diffuse X-ray scattering, which so far has been very challenging to measure and interpret. Here the authors present a finely sampled diffuse scattering map from triclinic lysozyme, which allows them to resolve inter-
Externí odkaz:
https://doaj.org/article/acda98e77c5f4f089df2421fefdb87e6
Autor:
Jonathon G. Gray, David A. Case
Publikováno v:
Crystals, Vol 11, Iss 7, p 771 (2021)
Atomic models for nucleic acids derived from X-ray diffraction data at low resolution provide much useful information, but the observed scattering intensities can be fit with models that can differ in structural detail. Tradtional geometric restraint
Externí odkaz:
https://doaj.org/article/2f1f1c985c7e475a84c5e0dfc684df8e
Publikováno v:
Biomolecules, Vol 7, Iss 4, p 76 (2017)
Fibrillar collagens are the most abundant proteins in the extracellular matrix. Not only do they provide structural integrity to all of the connective tissues in the human body, but also their interactions with multiple cell receptors and other matri
Externí odkaz:
https://doaj.org/article/5aed463ac6854ffd97be61db9f68d948
Autor:
Cordell M. Baker, Joshua C. Hunsaker, Zach A. Folzenlogen, Glenn L. Pride, David E. Case, Babu G. Welch, Jonathan A. White, Christopher D. Roark, Andrew C. White, Joshua Seinfeld, John Muse, Ramesh Grandhi, Philipp Taussky
Publikováno v:
Operative Neurosurgery. 24:e255-e263
Publikováno v:
The Journal of Physical Chemistry B. 126:5982-5990
Electrostatic interactions are fundamental to RNA structure and function, and intimately influenced by solvation and the ion atmosphere. RNA enzymes, or ribozymes, are catalytic RNAs that are able to enhance reaction rates over a million-fold, despit