Zobrazeno 1 - 10
of 1 987
pro vyhledávání: '"David A. Brooks"'
Autor:
Kristian Juul-Madsen, Peter Parbo, Rola Ismail, Peter L. Ovesen, Vanessa Schmidt, Lasse S. Madsen, Jacob Thyrsted, Sarah Gierl, Mihaela Breum, Agnete Larsen, Morten N. Andersen, Marina Romero-Ramos, Christian K. Holm, Gregers R. Andersen, Huaying Zhao, Peter Schuck, Jens V. Nygaard, Duncan S. Sutherland, Simon F. Eskildsen, Thomas E. Willnow, David J. Brooks, Thomas Vorup-Jensen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The peripheral immune system is important in neurodegenerative diseases, both in protecting and inflaming the brain, but the underlying mechanisms remain elusive. Alzheimer’s Disease is commonly preceded by a prodromal period. Here, we rep
Externí odkaz:
https://doaj.org/article/81c39ad41509420b82e48e637c1da445
Autor:
Hilmar P. Sigurdsson, Lisa Alcock, Michael Firbank, Ross Wilson, Philip Brown, Ross Maxwell, Elizabeth Bennett, Nicola Pavese, David J. Brooks, Lynn Rochester
Publikováno v:
NeuroImage, Vol 288, Iss , Pp 120531- (2024)
Gait is an excellent indicator of physical, emotional, and mental health. Previous studies have shown that gait impairments in ageing are common, but the neural basis of these impairments are unclear. Existing methodologies are suboptimal and novel p
Externí odkaz:
https://doaj.org/article/c096ef344398443a92479200422bd187
Autor:
Mengdi Guo, Diala Abd-Rabbo, Bruna C. Bertol, Madeleine Carew, Sabelo Lukhele, Laura M. Snell, Wenxi Xu, Giselle M. Boukhaled, Heidi Elsaesser, Marie Jo Halaby, Naoto Hirano, Tracy L. McGaha, David G. Brooks
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113047- (2023)
Summary: CD4 T cells are central effectors of anti-cancer immunity and immunotherapy, yet the regulation of CD4 tumor-specific T (TTS) cells is unclear. We demonstrate that CD4 TTS cells are quickly primed and begin to divide following tumor initiati
Externí odkaz:
https://doaj.org/article/e4149f45150d4ef1af757d28b5084332
Autor:
David M. Long, Deborah Baker, Andy S. H. To, Lidia van Driel-Gesztelyi, David H. Brooks, Marco Stangalini, Mariarita Murabito, Alexander W. James, Mihalis Mathioudakis, Paola Testa
Publikováno v:
The Astrophysical Journal, Vol 965, Iss 1, p 63 (2024)
The composition of the solar corona differs from that of the photosphere, with the plasma thought to fractionate in the solar chromosphere according to the first ionization potential (FIP) of the different elements. This produces a FIP bias, wherein
Externí odkaz:
https://doaj.org/article/57c3e388a81c4a13ab11abb23ce025f5
Publikováno v:
The Astrophysical Journal, Vol 962, Iss 2, p 105 (2024)
A significant impediment to solving the coronal heating problem is that we currently only observe active region loops in their cooling phase. Previous studies showed that the evolution of cooling loop densities and apex temperatures is insensitive to
Externí odkaz:
https://doaj.org/article/5db78e84c8c546019e6e41d18241e3f1
Publikováno v:
Frontiers in Astronomy and Space Sciences, Vol 10 (2023)
We assess the on-orbit performance of the flare event trigger for the Hinode EUV Imaging Spectrometer. Our goal is to understand the time-delay between the occurrence of a flare, as defined by a prompt rise in soft X-ray emission, and the initiation
Externí odkaz:
https://doaj.org/article/06fe8c0a44f04990825ca4118f4fa187
Autor:
Jacob Horsager, Niels Okkels, Nathalie Van Den Berge, Jan Jacobsen, Anna Schact, Ole Lajord Munk, Kim Vang, Dirk Bender, David J. Brooks, Per Borghammer
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Background The autonomic nervous system is frequently affected in some neurodegenerative diseases, including Parkinson’s disease and Dementia with Lewy bodies. In vivo imaging methods to visualize and quantify the peripheral cholinergic ne
Externí odkaz:
https://doaj.org/article/dea18ac0e9764365a8f638a14a74f226
Autor:
Ignacio Ugarte-Urra, Peter R. Young, David H. Brooks, Harry P. Warren, Bart De Pontieu, Paul Bryans, Jeffrey W. Reep, Cooper Downs, Amy R. Winebarger, Samuel D. Tun
Publikováno v:
Frontiers in Astronomy and Space Sciences, Vol 9 (2023)
In the context of the recent call for white papers for the Decadal Survey for Solar and Space Physics (Heliophysics) 2024–2033, we present the argument that spatially-resolved spectral diagnostics over the full solar disk should be made a high-prio
Externí odkaz:
https://doaj.org/article/c2abc91326a0462e83d93d5b63a01be7
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101643- (2022)
Summary: This is a cytometry by time-of-flight (CyTOF) staining protocol for hematopoietic-derived cells, that leverages live-cell barcoding using receptor-type tyrosine-protein phosphatase C (CD45) antibodies conjugated to metal isotopes in combinat
Externí odkaz:
https://doaj.org/article/317fbfb48ce149088f7a8eb4475eb616
Autor:
S. Y. Cindy Yang, Scott C. Lien, Ben X. Wang, Derek L. Clouthier, Youstina Hanna, Iulia Cirlan, Kelsey Zhu, Jeffrey P. Bruce, Samah El Ghamrasni, Marco A. J. Iafolla, Marc Oliva, Aaron R. Hansen, Anna Spreafico, Philippe L. Bedard, Stephanie Lheureux, Albiruni Razak, Vanessa Speers, Hal K. Berman, Alexey Aleshin, Benjamin Haibe-Kains, David G. Brooks, Tracy L. McGaha, Marcus O. Butler, Scott V. Bratman, Pamela S. Ohashi, Lillian L. Siu, Trevor J. Pugh
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Although circulating tumour DNA (ctDNA) can predict immune checkpoint blockade (ICB) responses, its association with tumour biomarkers remains unknown. Here, the authors use ctDNA to inform exome and transcriptome profiling of >100 patients with 30 c
Externí odkaz:
https://doaj.org/article/2a55653c8f4a4ed888f461e4bdb5696f