Zobrazeno 1 - 10
of 30
pro vyhledávání: '"David A. Boyles"'
Autor:
Mohammad S. Alomar, David A. Boyles
Publikováno v:
ACS Omega, Vol 4, Iss 27, Pp 22363-22372 (2019)
Externí odkaz:
https://doaj.org/article/c6206a94c42241758fb74efe7737cd00
Autor:
Manjinder S. Lall, David C. Boyles, Gerald A. Weisenburger, Barbara J. Sitter, Yong Tao, Andrew Morgan Stewart, Susan C. Lilley, Robert J. Rafka, Sebastian D. Pattavina, Jan Szeliga
Publikováno v:
Organic Process Research & Development. 23:2499-2509
An efficient process to synthesize Monobactam 1 from intermediates 2, 3, and 4 was developed. The process was initially enabled to deliver 500 g of 1 for exploratory toxicity studies and further im...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc24a7505b25646bb5d4c4e452ec18ff
https://doi.org/10.1021/acs.oprd.9b00374
https://doi.org/10.1021/acs.oprd.9b00374
Autor:
David C. Boyles, Jianmin Sun, Joel T. Arcari, Matthew Frank Brown, Yong Tao, Susan C. Lilley, Jeremy T. Starr, Manjinder S. Lall, Andrew Morgan Stewart, Mark J. Mitton-Fry, David B. Damon
Publikováno v:
Organic Process Research & Development. 22:212-218
Process development and multikilogram synthesis of the monocyclic β-lactam core 17 for a novel pyridone-conjugated monobactam antibiotic is described. Starting with commercially available 2-(2,2-diethoxyethyl)isoindoline-1,3-dione, the five-step syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ca072f8a0203aaf9f04ea26283ffbc0
https://doi.org/10.1021/acs.oprd.7b00359
https://doi.org/10.1021/acs.oprd.7b00359
Autor:
Jotham Wadsworth Coe, Phillip J. Fiore, Ian Edmonds, Jeffrey B. Sperry, Wiglesworth Kristin, Eugene Lvovich Piatnitski Chekler, Jonathan Langille, David C. Boyles, Roberta Louise Dorow, David B. Damon
Publikováno v:
Organic Process Research & Development. 18:1752-1758
This work describes the optimization and scale-up of a Buchwald–Hartwig amination reaction for the preparation of a pharmaceutical intermediate. This C–N bond formation is challenged by the use of a chiral primary amine, which both adds cost and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::470ba14d178fb0c8d303c2bfa1cd4ece
https://doi.org/10.1021/op5002319
https://doi.org/10.1021/op5002319
Autor:
John T. Bendler, C.A. Edmondson, Mary C. Wintersgill, David A. Boyles, John J. Fontanella, Tsvetanka Filipova, Mark A. Westgate
Publikováno v:
Macromolecules. 46:4024-4033
The relative permittivity and dielectric strength have been determined for a bisphenol A polycarbonate (BPA-PC), in which a cyanoethyl group has been substituted for one of the geminal dimethyl groups. The new material (CN-PC) has a glass transition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cffaa684f109cf8373161af01cdc07b
https://doi.org/10.1021/ma4002269
https://doi.org/10.1021/ma4002269
Autor:
Tsvetanka Filipova, David A. Boyles, John T. Bendler, C.A. Edmondson, Mary C. Wintersgill, John J. Fontanella
Publikováno v:
European Polymer Journal. 48:830-840
The relative permittivity, loss and dielectric strength have been measured for a polycarbonate-based material, tetraaryl bisphenol A polycarbonate, that has been fluorine substituted (DiF p-TABPA-PC). The new material has a glass transition temperatu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7209e0c25e1a8cb9e2cce59c8028d07a
https://doi.org/10.1016/j.eurpolymj.2012.02.001
https://doi.org/10.1016/j.eurpolymj.2012.02.001
Autor:
John J. Fontanella, Maria J. Schroeder, Mary C. Wintersgill, Joseph F. Lomax, Shady Helmi Awwad, Tsvetanka Filipova, C.A. Edmondson, David A. Boyles, John T. Bendler
Publikováno v:
Journal of Polymer Science Part B: Polymer Physics. 50:289-304
The relative permittivity, loss, and breakdown strength are reported for a commercial sample of bisphenol A-polycarbonate (comm-BPA-PC) and a purified sample of the same polymer (rp-BPA-PC) as well as for two new polycarbonates having low molecular c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35d40706bb67474050e2d7dde41e7fce
https://doi.org/10.1002/polb.23010
https://doi.org/10.1002/polb.23010
Autor:
Ian B. Moses, Rick Rodriguez, Peter Robert Rose, Corey L. Stanchina, Cuthbertson Timothy J, Asayuki Kamatani, Pieter D. de Koning, Alison Sandoval, Kyle Kissick, Robert Moore, Leera Rahman, Douglas McAndrew, Armando Urbina, David C. Boyles
Publikováno v:
Organic Process Research & Development. 15:1018-1026
A robust six-step process for the synthesis of crizotinib, a novel c-Met/ALK inhibitor currently in phase III clinical trials, has been developed and used to deliver over 100 kg of API. The process includes a Mitsunobu reaction, a chemoselective redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fd5a1469f77db90ff994ded3cb5273e
https://doi.org/10.1021/op200131n
https://doi.org/10.1021/op200131n
Autor:
David A. Boyles, Josiah T. Reams
Publikováno v:
Journal of Applied Polymer Science. 121:756-763
Three isomeric tetraaryl cyanate esters containing biphenyl moieties {bis-[4-(4′-cyanatophenyl)phenyl]propane, 2,2-bis-[4-(3′-cyanatophenyl)phenyl]propane, and 2,2-bis-[4-(2′-cyanatophenyl)phenyl]propane} and three isomeric triaryl cyanate este
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eab201f18d8f409dc51f4f00f9c9473
https://doi.org/10.1002/app.33360
https://doi.org/10.1002/app.33360
Autor:
David C. Boyles, Stephanie Schuyler, Edward J. Hessler, Jeffrey A. Pfefferkorn, Daniel Merritt Bowles, Chulho Choi
Publikováno v:
Organic Process Research & Development. 15:148-157
Early process development work toward a promising pyrazole-based HMG-CoA reductase inhibitor is described. PF-03052334-02 (1) was prepared in 14 synthetic steps with a 21% overall yield, highlighted by a modified three-step hydroxypyrazole formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3244cefc6fb774fd450882bea2ca9fe2
https://doi.org/10.1021/op100268e
https://doi.org/10.1021/op100268e