Clinical utility of WHO-recommended screening tools and development and validation of novel clinical prediction models for pulmonary tuberculosis screening among outpatients living with HIV: an individual participant data meta-analysis

Autor: Ashar Dhana, Rishi K. Gupta, Yohhei Hamada, Andre P. Kengne, Andrew D. Kerkhoff, Christina Yoon, Adithya Cattamanchi, Byron W.P. Reeve, Grant Theron, Gcobisa Ndlangalavu, Robin Wood, Paul K. Drain, Claire J. Calderwood, Mahdad Noursadeghi, Tom Boyles, Graeme Meintjes, Gary Maartens, David A. Barr

Publikováno v: European Respiratory Review, Vol 32, Iss 168 (2023)

Background: The World Health Organization (WHO) recommends that outpatient people living with HIV (PLHIV) undergo tuberculosis screening with the WHO four-symptom screen (W4SS) or C-reactive protein (CRP) (5 mg·L−1 cut-off) followed by confirmator

Externí odkaz: https://doaj.org/article/c3ec9d7f1d364792a9377ea5aa72c7c0

Serial measurement of M. tuberculosis in blood from critically-ill patients with HIV-associated tuberculosis

Autor: David A. Barr, Charlotte Schutz, Avuyonke Balfour, Muki Shey, Mireille Kamariza, Carolyn R. Bertozzi, Timothy J. de Wet, Ryan Dinkele, Amy Ward, Kathryn A. Haigh, Jean-Paul Kanyik, Valerie Mizrahi, Mark P. Nicol, Robert J. Wilkinson, David G. Lalloo, Digby F. Warner, Graeme Meintjes, Gerry Davies

Publikováno v: EBioMedicine, Vol 78, Iss , Pp 103949- (2022)

Summary: Background: Despite being highly prevalent in hospitalised patients with severe HIV-associated tuberculosis (TB) and sepsis, little is known about the mycobacteriology of Mycobacterium tuberculosis bloodstream infection (MTBBSI). We develope

Externí odkaz: https://doaj.org/article/b23d542ff14a41e78eaf5d443a71e548

Xpert Ultra testing of blood in severe HIV-associated tuberculosis to detect and measure Mycobacterium tuberculosis blood stream infection: a diagnostic and disease biomarker cohort study

Autor: Linda Boloko, Charlotte Schutz, Nomfundo Sibiya, Avuyonke Balfour, Amy Ward, Muki Shey, Mark P Nicol, Rosie Burton, Robert J Wilkinson, Gary Maartens, Graeme Meintjes, David A Barr

Publikováno v: The Lancet Microbe. 3:e521-e532

BACKGROUND: Mycobacterium tuberculosis bloodstream infection is a leading cause of death in people living with HIV and disseminated bacillary load might be a key driver of disease severity. We aimed to assess Xpert MTB/RIF Ultra (Xpert Ultra) testing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2ba3c4a74fb4eb2dddaec645dc74ec
https://doi.org/10.1016/s2666-5247(22)00062-3

Sensitivity of SARS-CoV-2 RNA polymerase chain reaction using a clinical and radiological reference standard

Autor: Muhammad S Ahmed, Diana Penha, Sheetal Sharma, Cairine Probert, Michael Beadsworth, Catriona Farrell, Katharine E. Stott, Meng-San Wu, Elizabeth Joekes, Rory Hicks, David A Barr, Beth Hankinson, Stacy Todd, James Cruise, Kathryn Haigh, Tamsin Paterson, Fred Fyles, Vijay Chindambaram, Nuria Santamaria, Alice Maxwell, Michael Abouyannis, Alexander J. Stockdale, Nick Moody, Rashika Fernando, Joseph M. Lewis, Imogen Fordham, Rebecca Wiles

Publikováno v: The Journal of Infection

Objectives Diagnostic tests for SARS-CoV-2 are important for epidemiology, clinical management, and infection control. Limitations of oro-nasopharyngeal real-time PCR sensitivity have been described based on comparisons of single tests with repeated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156bd2461a8eff98ac65a081d40a8691
https://doi.org/10.1016/j.jinf.2021.04.012

Tuberculosis screening among HIV-positive inpatients: a systematic review and individual participant data meta-analysis

Autor: Ashar Dhana, Yohhei Hamada, Andre P Kengne, Andrew D Kerkhoff, Molebogeng X Rangaka, Tamara Kredo, Annabel Baddeley, Cecily Miller, Ankur Gupta-Wright, Katherine Fielding, Robin Wood, Helena Huerga, Sekai Chenai Mathabire Rücker, Christine Heidebrecht, Douglas Wilson, Stephanie Bjerrum, Isik S Johansen, Swe Swe Thit, Mar Mar Kyi, Josh Hanson, David A Barr, Graeme Meintjes, Gary Maartens

Publikováno v: The lancet. HIV
Dhana, A, Hamada, Y, Kengne, A P, Kerkhoff, A D, Rangaka, M X, Kredo, T, Baddeley, A, Miller, C, Gupta-Wright, A, Fielding, K, Wood, R, Huerga, H, Rücker, S C M, Heidebrecht, C, Wilson, D, Bjerrum, S, Johansen, I S, Thit, S S, Kyi, M M, Hanson, J, Barr, D A, Meintjes, G & Maartens, G 2022, ' Tuberculosis screening among HIV-positive inpatients : a systematic review and individual participant data meta-analysis ', The Lancet HIV, vol. 9, no. 4, pp. e233-e241 . https://doi.org/10.1016/S2352-3018(22)00002-9

BackgroundSince 2011, WHO has recommended that HIV-positive inpatients be routinely screened for tuberculosis with the WHO four-symptom screen (W4SS) and, if screened positive, receive a molecular WHO-recommended rapid diagnostic test (eg, Xpert MTB/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d1dd3500da4263f8a536c010ce55c2
http://livrepository.liverpool.ac.uk/3152689/1/PIIS2352301822000029.pdf