Zobrazeno 1 - 10
of 4 140
pro vyhledávání: '"David A. Baker"'
Autor:
Avnish Patel, Aline Fréville, Joshua A. Rey, Helen R. Flynn, Konstantinos Koussis, Mark J. Skehel, Michael J. Blackman, David A. Baker
Publikováno v:
mBio, Vol 15, Iss 11 (2024)
ABSTRACT We previously reported that the Plasmodium falciparum putative serine/threonine protein phosphatase 7 (PP7) is a high-confidence substrate of the cAMP-dependent protein kinase (PKA). Here we explore the function of PP7 in asexual P. falcipar
Externí odkaz:
https://doaj.org/article/8e1daffe95784ff5ad6aba222b2a6941
Autor:
Aline Freville, Lindsay B. Stewart, Kevin K. A. Tetteh, Moritz Treeck, Alfred Cortes, Till S. Voss, Sarah J. Tarr, David A. Baker, David J. Conway
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTThe Plasmodium falciparum merozoite surface protein MSPDBL2 is a polymorphic antigen targeted by acquired immune responses, and normally expressed in only a minority of mature schizonts. The potential relationship of MSPDBL2 to sexual commitm
Externí odkaz:
https://doaj.org/article/a3c074ac2bf04bf99c760a62f54b71a2
Autor:
Lindsay B. Stewart, Aline Freville, Till S. Voss, David A. Baker, Gordon A. Awandare, David J. Conway
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT Asexual blood-stage malaria parasites must produce sexual progeny to infect mosquitoes. It is important to understand the scope and causes of intraspecific variation in sexual commitment rates, particularly for the major human parasite P. fa
Externí odkaz:
https://doaj.org/article/c945b530d1bd487fa6c592d91ace00d6
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT In model organisms, type IV ATPases (P4-ATPases) require cell division control protein 50 (CDC50) chaperones for their phospholipid flipping activity. In the malaria parasite Plasmodium falciparum, guanylyl cyclase alpha (GCα) is an integra
Externí odkaz:
https://doaj.org/article/274f48a5efab4ec797951ca71d34392b
Autor:
Trent M. Prall, Emma K. Neumann, Julie A. Karl, Cecilia G. Shortreed, David A. Baker, Hailey E. Bussan, Roger W. Wiseman, David H. O’Connor
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background Oxford Nanopore Technologies’ instruments can sequence reads of great length. Long reads improve sequence assemblies by unambiguously spanning repetitive elements of the genome. Sequencing reads of significant length requires th
Externí odkaz:
https://doaj.org/article/7abaa99c2c9742b3894e3dd25ba0d864
Autor:
Gregory Simandl, Gregory J. Simandl, Evan Hess, Linghai Kong, Nicholas J. Raddatz, Matthew M. Hurley, Brian Maunze, SuJean Choi, Aaron M. Geurts, David A. Baker
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 145-145 (2023)
OBJECTIVES/GOALS: We aim to discover safer and more effective therapeutics for CNS disorders. Current therapeutic development is hindered by dosing out drugs for safe consumption. By identifying proteins with narrow functional roles in the brain (i.e
Externí odkaz:
https://doaj.org/article/e95a333379c64267a47095434505eef3
Autor:
Grazia Camarda, Piyaporn Jirawatcharadech, Richard S. Priestley, Ahmed Saif, Sandra March, Michael H. L. Wong, Suet Leung, Alex B. Miller, David A. Baker, Pietro Alano, Mark J. I. Paine, Sangeeta N. Bhatia, Paul M. O’Neill, Stephen A. Ward, Giancarlo A. Biagini
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Primaquine (PQ) is a widely used anti-malaria drug, but its mechanism of action is unclear. Here, Camarda et al. show that PQ’s activity against liver and sexual Plasmodium stages depends on generation of hydroxylated-PQ metabolites (OH-PQm), which
Externí odkaz:
https://doaj.org/article/53df786506df4fffaf54431621d57eba
Autor:
Maria Penzo, Laura de las Heras-Dueña, Lydia Mata-Cantero, Beatriz Diaz-Hernandez, Maria-Jesus Vazquez-Muñiz, Sonja Ghidelli-Disse, Gerard Drewes, Elena Fernandez-Alvaro, David A. Baker
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract Antimalarial drug resistance compels the quest for new compounds that target alternative pathways to current drugs. The Plasmodium cyclic GMP-dependent protein kinase (PKG) has essential functions in all of the major life cycle developmental
Externí odkaz:
https://doaj.org/article/7b1853796974419994e20d37569169f5
Autor:
Abigail J. Perrin, Claudine Bisson, Peter A. Faull, Matthew J. Renshaw, Rebecca A. Lees, Roland A. Fleck, Helen R. Saibil, Ambrosius P. Snijders, David A. Baker, Michael J. Blackman
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Malaria is a deadly infectious disease. Rationally designed novel therapeutics will be essential for its control and eradication.
Externí odkaz:
https://doaj.org/article/6ee9607081a545d7b55c84aede269aec
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
The clinical manifestations of malaria arise due to successive rounds of replication of Plasmodium
Externí odkaz:
https://doaj.org/article/002c8011b3bc41a3a9ea405439021f8a