Zobrazeno 1 - 10
of 451
pro vyhledávání: '"David A. Agard"'
Autor:
Un Seng Chio, Eugene Palovcak, Anton A. A. Smith, Henriette Autzen, Elise N. Muñoz, Zanlin Yu, Feng Wang, David A. Agard, Jean-Paul Armache, Geeta J. Narlikar, Yifan Cheng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Single-particle cryo-EM is widely used to determine enzyme-nucleosome complex structures. However, cryo-EM sample preparation remains challenging and inconsistent due to complex denaturation at the air-water interface (AWI). Here, to address
Externí odkaz:
https://doaj.org/article/27aa364ca261463cb826925799de5972
Autor:
Andrea Fossati, Deepto Mozumdar, Claire Kokontis, Melissa Mèndez-Moran, Eliza Nieweglowska, Adrian Pelin, Yuping Li, Baron Guo, Nevan J. Krogan, David A. Agard, Joseph Bondy-Denomy, Danielle L. Swaney
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Host-pathogen interactions are pivotal in regulating establishment, progression, and outcome of an infection. While affinity-purification mass spectrometry has become instrumental in characterizing such interactions, it suffers from limitati
Externí odkaz:
https://doaj.org/article/bfb0742bdc28451aa8144fcd925343ed
Autor:
Maru Jaime-Garza, Carlos A. Nowotny, Daniel Coutandin, Feng Wang, Mariano Tabios, David A. Agard
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The Hsp90 molecular chaperone collaborates with the phosphorylated Cdc37 cochaperone for the folding and activation of its many client kinases. As with many kinases, the Hsp90 client kinase CRaf is activated by phosphorylation at specific re
Externí odkaz:
https://doaj.org/article/f4dae4dff3af402bb7da3cc3f3e9e00c
Autor:
Eliza S. Nieweglowska, Axel F. Brilot, Melissa Méndez-Moran, Claire Kokontis, Minkyung Baek, Junrui Li, Yifan Cheng, David Baker, Joseph Bondy-Denomy, David A. Agard
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
To protect from host attack, numerous jumbo bacteriophages establish a micron-scale, protein-based structure to enclose their replicating DNA. Using cryoEM, the authors show that the 2D crystal enclosing this so-called phage nucleus is an assembly of
Externí odkaz:
https://doaj.org/article/f7a9df2988ef437aa0a60e5c599bd823
Autor:
Shawn Zheng, Georg Wolff, Garrett Greenan, Zhen Chen, Frank G.A. Faas, Montserrat Bárcena, Abraham J. Koster, Yifan Cheng, David A. Agard
Publikováno v:
Journal of Structural Biology: X, Vol 6, Iss , Pp 100068- (2022)
AreTomo, an abbreviation for Alignment and Reconstruction for Electron Tomography, is a GPU accelerated software package that fully automates motion-corrected marker-free tomographic alignment and reconstruction in a single package. By correcting in-
Externí odkaz:
https://doaj.org/article/8cf7635fbb844f1d9b77ae94bc3a04d3
Autor:
Abhinav Joshi, Li Dai, Yanxin Liu, Jungsoon Lee, Nastaran Mohammadi Ghahhari, Gregory Segala, Kristin Beebe, Lisa M. Jenkins, Gaelyn C. Lyons, Lilia Bernasconi, Francis T. F. Tsai, David A. Agard, Len Neckers, Didier Picard
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-23 (2020)
Abstract Background The molecular chaperone TRAP1, the mitochondrial isoform of cytosolic HSP90, remains poorly understood with respect to its pivotal role in the regulation of mitochondrial metabolism. Most studies have found it to be an inhibitor o
Externí odkaz:
https://doaj.org/article/e2196003fcc841a4afae75d1e8f78cab
Autor:
Rebecca Freilich, Miguel Betegon, Eric Tse, Sue-Ann Mok, Olivier Julien, David A. Agard, Daniel R. Southworth, Koh Takeuchi, Jason E. Gestwicki
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Small heat shock proteins (sHSPs) limit the aggregation of proteins, such as tau. Here the authors show that Hsp27 recognizes two aggregation-prone regions of tau and that this interaction competes with Hsp27 oligomerization.
Externí odkaz:
https://doaj.org/article/ea828c6ee26840cd8de08621cb5f0b7d
Autor:
Jayachandran Gopalakrishnan, Vito Mennella, Stephanie Blachon, Bo Zhai, Andrew H. Smith, Timothy L. Megraw, Daniela Nicastro, Steven P. Gygi, David A. Agard, Tomer Avidor-Reiss
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-2 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/5f23f6c0cb1e492d8178aacc26859bdc
Publikováno v:
Urology. 175:175-180
Autor:
Michael R. Hoopmann, David D. Shteynberg, Alex Zelter, Michael Riffle, Andrew S. Lyon, David A. Agard, Qing Luan, Brad J. Nolen, Michael J. MacCoss, Trisha N. Davis, Robert L. Moritz
Publikováno v:
Journal of Proteome Research. 22:647-655