Zobrazeno 1 - 10
of 420
pro vyhledávání: '"David A. Stein"'
Autor:
Alexandra Sakai, Gagandeep Singh, Mahsa Khoshbakht, Scott Bittner, Christiane V. Löhr, Randy Diaz-Tapia, Prajakta Warang, Kris White, Luke Le Luo, Blanton Tolbert, Mario Blanco, Amy Chow, Mitchell Guttman, Cuiping Li, Yiming Bao, Joses Ho, Sebastian Maurer-Stroh, Arnab Chatterjee, Sumit Chanda, Adolfo García-Sastre, Michael Schotsaert, John R. Teijaro, Hong M. Moulton, David A. Stein
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102331- (2024)
Further development of direct-acting antiviral agents against human SARS-CoV-2 infections remains a public health priority. Here, we report that an antisense peptide-conjugated morpholino oligomer (PPMO) named 5′END-2, targeting a highly conserved
Externí odkaz:
https://doaj.org/article/cde8602c5de243599a35a2d086e74e3b
Publikováno v:
Rambam Maimonides Medical Journal, Vol 15, Iss 4, p e0021 (2024)
Pancytopenia is defined as a reduction in red blood cells, white blood cells, and platelets, and can pose as a diagnostic challenge due to the multitude of causes. Myxedema coma is the manifestation of severe untreated hypothyroidism. This case repor
Externí odkaz:
https://doaj.org/article/b8b264a039184f5ab0e6d54e0950e662
Autor:
Marie Schwerdtner, Luna C. Schmacke, Julia Nave, Hannah Limburg, Torsten Steinmetzer, David A. Stein, Hong M. Moulton, Eva Böttcher-Friebertshäuser
Publikováno v:
Viruses, Vol 16, Iss 11, p 1798 (2024)
The zoonotic transmission of influenza A viruses (IAVs) and coronaviruses (CoVs) may result in severe disease. Cleavage of the surface glycoproteins hemagglutinin (HA) and spike protein (S), respectively, is essential for viral infectivity. The trans
Externí odkaz:
https://doaj.org/article/b9d683346e0040d5b78dbc6365d841b1
Autor:
Eric H. Rosenn, Mickael Benhaim, Allison Siegel, David A. Stein, Joseph S. Leonard, Erik Katcher, Dania Halperin, Zachary Mostel
Publikováno v:
Immuno, Vol 3, Iss 3, Pp 346-357 (2023)
Advancements in sequencing and screening technology have made monoclonal antibodies more accessible, cost-effective, and precise. These drugs effectively target pathogens and cancer cells and even regulate metabolic pathways by focusing on specific i
Externí odkaz:
https://doaj.org/article/a83910fa4ad9430598b3ef8f1bf4d8af
Autor:
Rosario Mercedes Meneses Castañeda, Sergio Luis Ramos Rodriguez, Chiara del Carmen Molfino Jaramillo, Ely Luisa Sánchez Miraval, David Francisco Stein Montoro, Lourdes Guissel Chávez Rodríguez
Publikováno v:
Revista de la Facultad de Medicina Humana, Vol 23, Iss 1, Pp 25-32 (2023)
Introduction: Students during virtual classes due to COVID-19 may develop computer visual syndrome (SVI) due to excessive time in front of digital screens. Objective: To determine the frequency of computer vision syndrome in sixth-year medical studen
Externí odkaz:
https://doaj.org/article/fc8a31cd09914ace88850c12b9dc1a9a
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-7 (2022)
Rotor-like dynamics is observed in many natural systems, from the rotor proteins in cellular membranes to atmospheric models. Here, the authors uncover geometrical conservation laws that limit distribution of driven rotors in a membrane or a soap fil
Externí odkaz:
https://doaj.org/article/3535e763548147f3a9a7b3ec0327202b
Publikováno v:
Mathematical Biosciences and Engineering, Vol 18, Iss 3, Pp 2849-2881 (2021)
Active fluids consume fuel at the microscopic scale, converting this energy into forces that can drive macroscopic motions over scales far larger than their microscopic constituents. In some cases, the mechanisms that give rise to this phenomenon hav
Externí odkaz:
https://doaj.org/article/0bc64f55899846948eda71572e358df6
Autor:
David F. Stein, Huidong Chen, Michael E. Vinyard, Qian Qin, Rebecca D. Combs, Qian Zhang, Luca Pinello
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Single-cell assays have transformed our ability to model heterogeneity within cell populations. As these assays have advanced in their ability to measure various aspects of molecular processes in cells, computational methods to analyze and meaningful
Externí odkaz:
https://doaj.org/article/3ecbc0b74fde43aab49aec3ba8f72dc7
Autor:
Leslie M Stevens, Goheun Kim, Theodora Koromila, John W Steele, James McGehee, Angelike Stathopoulos, David S Stein
Publikováno v:
PLoS Genetics, Vol 17, Iss 5, p e1009544 (2021)
Here we describe the development and characterization of the photo-N-degron, a peptide tag that can be used in optogenetic studies of protein function in vivo. The photo-N-degron can be expressed as a genetic fusion to the amino termini of other prot
Externí odkaz:
https://doaj.org/article/757efd65f0604ed4b7c73e7ef3d79d0d
Autor:
David E. Stein, MD, MHCM, Stanley H. Chia, MD, Thomas H. Breakey, MHA, David H. Song, MD, MBA, Edward Y. Woo, MD, Rollin J. Fairbanks, MD, MS, David Jordan, MD, Leigh Ann Curl, MD, Henry R. Boucher, MD, Lisa Boyle, MD, Karol Edwards, RN, MHA, NE-BC, Hanna Friedrich, BSN, Robert J. Gilbert, MHA, Jeffrey Matton, MHA, Kathy Mucci, MBA, RN, Bradley Chambers, MS, Michael Sachtleben, MHA, Thomas J. Watson, MD
Publikováno v:
Annals of Surgery Open, Vol 1, Iss 1, p e002 (2020)
Introduction:. Coronavirus disease 2019 (COVID-19) infections have strained hospital resources worldwide. As a result, many facilities have suspended elective operations and ambulatory procedures. As the incidence of new cases of COVID-19 decreases,
Externí odkaz:
https://doaj.org/article/c9f2439c1c9540bdbe548b3e85663a49