Zobrazeno 1 - 10
of 81
pro vyhledávání: '"David A. Keays"'
Autor:
Ines Leca, Alexander William Phillips, Lyubov Ushakova, Thomas David Cushion, David Anthony Keays
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract The tubulinopathies are an umbrella of rare diseases that result from mutations in tubulin genes and are frequently characterised by severe brain malformations. The characteristics of a given disease reflect the expression pattern of the tra
Externí odkaz:
https://doaj.org/article/f30ef63a6a784c2c867a80ab0498f92b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Microtubules are filamentous structures that play a critical role in a diverse array of cellular functions including, mitosis, nuclear translocation, trafficking of organelles and cell shape. They are composed of α/β-tubulin heterodimers which are
Externí odkaz:
https://doaj.org/article/3922d74c3693453383885241fa51927f
Autor:
Spencer D. Balay, Tobias Hochstoeger, Alexandra Vilceanu, E. Pascal Malkemper, William Snider, Gerhard Dürnberger, Karl Mechtler, Stefan Schuechner, Egon Ogris, Gregory C. Nordmann, Lyubov Ushakova, Simon Nimpf, David A. Keays
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Cryptochromes (CRY) are highly conserved signalling molecules that regulate circadian rhythms and are candidate radical pair based magnetoreceptors. Birds have at least four cryptochromes (CRY1a, CRY1b, CRY2, and CRY4), but few studies have
Externí odkaz:
https://doaj.org/article/088540efee3c4edaa5c3ab06f0fe4c93
Autor:
Simon Nimpf, David A. Keays
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104454- (2022)
Summary: The ability to detect magnetic fields is a sensory modality that is used by many animals to navigate. While first postulated in the 1800s, for decades, it was considered a biological myth. A series of elegant behavioral experiments in the 19
Externí odkaz:
https://doaj.org/article/c40b2925a8bc4989a42347e34c97b6fa
Autor:
Ines Leca, Alexander William Phillips, Iris Hofer, Lukas Landler, Lyubov Ushakova, Thomas David Cushion, Gerhard Dürnberger, Karel Stejskal, Karl Mechtler, David Anthony Keays
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1009104 (2020)
Microtubules play a critical role in multiple aspects of neurodevelopment, including the generation, migration and differentiation of neurons. A recurrent mutation (R402H) in the α-tubulin gene TUBA1A is known to cause lissencephaly with cerebellar
Externí odkaz:
https://doaj.org/article/f13b614748244440922147278bdf91aa
Autor:
Carson Holt, Michael Campbell, David A. Keays, Nathaniel Edelman, Aurélie Kapusta, Emily Maclary, Eric T. Domyan, Alexander Suh, Wesley C. Warren, Mark Yandell, M. Thomas P. Gilbert, Michael D. Shapiro
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 5, Pp 1391-1398 (2018)
The domestic rock pigeon (Columba livia) is among the most widely distributed and phenotypically diverse avian species. C. livia is broadly studied in ecology, genetics, physiology, behavior, and evolutionary biology, and has recently emerged as a mo
Externí odkaz:
https://doaj.org/article/d9b14450ec464ee8a99ae08a32921dce
Autor:
Matilda A. Haas, Linh Ngo, Shan Shan Li, Sibylle Schleich, Zhengdong Qu, Hannah K. Vanyai, Hayley D. Cullen, Aida Cardona-Alberich, Ivan E. Gladwyn-Ng, Alistair T. Pagnamenta, Jenny C. Taylor, Helen Stewart, Usha Kini, Kent E. Duncan, Aurelio A. Teleman, David A. Keays, Julian I.-T. Heng
Publikováno v:
Cell Reports, Vol 15, Iss 10, Pp 2251-2265 (2016)
Disruptions to neuronal mRNA translation are hypothesized to underlie human neurodevelopmental syndromes. Notably, the mRNA translation re-initiation factor DENR is a regulator of eukaryotic translation and cell growth, but its mammalian functions ar
Externí odkaz:
https://doaj.org/article/a4081fe8d694484daeb5f90052f7eb79
Autor:
Lukas Landler, David A Keays
Publikováno v:
PLoS Biology, Vol 16, Iss 10, p e3000018 (2018)
Over the last three decades, evidence has emerged that low-intensity magnetic fields can influence biological systems. It is now well established that migratory birds have the capacity to detect the Earth's magnetic field; it has been reported that p
Externí odkaz:
https://doaj.org/article/0f52e5b60d49448e9b9d03dfb5e03536
Publikováno v:
Biology Open, Vol 7, Iss 8 (2018)
The vertebrate inner ear contains vestibular receptors with dense crystals of calcium carbonate, the otoconia. The production and maintenance of otoconia is a delicate process, the perturbation of which can lead to severe vestibular dysfunction in hu
Externí odkaz:
https://doaj.org/article/e98226855e26436f98f5d1bb17520d27
Autor:
Lukas Landler, Simon Nimpf, Tobias Hochstoeger, Gregory C Nordmann, Artemis Papadaki-Anastasopoulou, David A Keays
Publikováno v:
eLife, Vol 7 (2018)
A diverse array of species on the planet employ the Earth's magnetic field as a navigational aid. As the majority of these animals are migratory, their utility to interrogate the molecular and cellular basis of the magnetic sense is limited. Vidal-Ga
Externí odkaz:
https://doaj.org/article/eda4cb6faca04e24b07f53c9919f369b