Zobrazeno 1 - 10
of 11
pro vyhledávání: '"David A Yarmolinsky"'
Autor:
James P Bohnslav, Nivanthika K Wimalasena, Kelsey J Clausing, Yu Y Dai, David A Yarmolinsky, Tomás Cruz, Adam D Kashlan, M Eugenia Chiappe, Lauren L Orefice, Clifford J Woolf, Christopher D Harvey
Publikováno v:
eLife, Vol 10 (2021)
Videos of animal behavior are used to quantify researcher-defined behaviors of interest to study neural function, gene mutations, and pharmacological therapies. Behaviors of interest are often scored manually, which is time-consuming, limited to few
Externí odkaz:
https://doaj.org/article/0490bc2a85ba4831a27480dbae549b72
Autor:
Zihe Zhang, David P. Roberson, Masakazu Kotoda, Bruno Boivin, James P. Bohnslav, Rafael González-Cano, David A. Yarmolinsky, Bruna Lenfers Turnes, Nivanthika K. Wimalasena, Shay Q. Neufeld, Lee B. Barrett, Nara L. M. Quintão, Victor Fattori, Daniel G. Taub, Alexander B. Wiltschko, Nick A. Andrews, Christopher D. Harvey, Sandeep Robert Datta, Clifford J. Woolf
The lack of sensitive and robust behavioral assessments of pain in preclinical models has been a major limitation for both pain research and the development of novel analgesics. Here, we demonstrate a novel data acquisition and analysis platform that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588f871a1fe1763ad305dec0c5e18f1d
https://hdl.handle.net/10481/78398
https://hdl.handle.net/10481/78398
Autor:
Kelsey J Clausing, Nivanthika K Wimalasena, Lauren L. Orefice, Yu Y Dai, Adam D Kashlan, Christopher D. Harvey, Clifford J. Woolf, M. Eugenia Chiappe, Tomás Cruz, James P Bohnslav, David A Yarmolinsky
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Videos of animal behavior are used to quantify researcher-defined behaviors of interest to study neural function, gene mutations, and pharmacological therapies. Behaviors of interest are often scored manually, which is time-consuming, limited to few
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a40a617760c272491d2595e312df16
https://doi.org/10.7554/elife.63377
https://doi.org/10.7554/elife.63377
Autor:
Christopher D. Harvey, Clifford J. Woolf, David A Yarmolinsky, Lauren L. Orefice, M. Eugenia Chiappe, Nivanthika K Wimalasena, Kelsey J Clausing, Tomás Cruz, James P Bohnslav, Yu Y Dai, Adam D Kashlan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00a9150081598d34e2a2c221246f5e81
https://doi.org/10.7554/elife.63377.sa2
https://doi.org/10.7554/elife.63377.sa2
Autor:
Christopher D. Harvey, Clifford J. Woolf, Masakazu Kotoda, Sandeep Robert Datta, Rafael Gonzalez-Cano, Bruno Boivin, David Roberson, Lee Barrett, Victor Fattori, Alexander B. Wiltschko, Zihe Zhang, David A Yarmolinsky, James P Bohnslav, Daniel Taub, Shay Q. Neufeld, Nivanthika K Wimalasena, Nara L. M. Quintão
Publikováno v:
SSRN Electronic Journal.
SUMMARYThe lack of robust quantifiable behavioral assessments of pain in pre-clinical models, especially of ongoing pain, has been a major limitation for both pain neurobiology research and development of novel analgesics. Current methods typically r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e91495c40bb829531409b4bc8d78b4b9
https://doi.org/10.2139/ssrn.3793964
https://doi.org/10.2139/ssrn.3793964
Autor:
Christopher D. Harvey, Clifford J. Woolf, James P Bohnslav, Tomás Cruz, Kelsey J Clausing, Lauren L. Orefice, eugenia chiappe, David A Yarmolinsky, Nivanthika K Wimalasena
Researchers commonly acquire videos of animal behavior and quantify the prevalence of behaviors of interest to study nervous system function, the effects of gene mutations, and the efficacy of pharmacological therapies. This analysis is typically per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a59c910378ca828995ccb550a47635ff
https://doi.org/10.1101/2020.09.24.312504
https://doi.org/10.1101/2020.09.24.312504
Autor:
Mark A. Hoon, David A. Yarmolinsky, Michael Rutlin, Yueqing Peng, Leah A. Pogorzala, Charles S. Zuker
Publikováno v:
Neuron. 92:1079-1092
Perception of the thermal environment begins with the activation of peripheral thermosensory neurons innervating the body surface. To understand how temperature is represented in vivo, we used genetically encoded calcium indicators to measure tempera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cfd0a695e12825a20733c0fdf7bd742
https://doi.org/10.1016/j.neuron.2016.10.021
https://doi.org/10.1016/j.neuron.2016.10.021
Autor:
David A. Yarmolinsky, Sarah Gillis-Smith, Mark J. Schnitzer, Charles S. Zuker, Nicholas J. P. Ryba, Jayaram Chandrashekar, Robert P. J. Barretto
Publikováno v:
Nature. 517:373-376
The mammalian taste system is responsible for sensing and responding to the five basic taste qualities: sweet, sour, bitter, salty and umami. Previously, we showed that each taste is detected by dedicated taste receptor cells (TRCs) on the tongue and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb049811bf5e5ca41e7f384c66b8be4
https://doi.org/10.1038/nature13873
https://doi.org/10.1038/nature13873
Autor:
Charles S. Zuker, David A. Yarmolinsky, Yuki Oka, Nicholas J. P. Ryba, Jayaram Chandrashekar, Christian Kuhn, Edith Hummler
Publikováno v:
Nature
Nature, vol. 464, no. 7286, pp. 297-301
Nature, vol. 464, no. 7286, pp. 297-301
Salt taste in mammals can trigger two divergent behavioural responses. In general, concentrated saline solutions elicit robust behavioural aversion, while low concentrations of NaCl are typically attractive, particularly after sodium depletion1-5. No
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166330b1eb1aa700163790276e849fe3
Publikováno v:
Cell. 139(2):234-244
The sense of taste is a specialized chemosensory system dedicated to the evaluation of food and drink. Despite the fact that vertebrates and insects have independently evolved distinct anatomic and molecular pathways for taste sensation, there are cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29dd06b1f94994c8ec02accc0e0bc152