Zobrazeno 1 - 10
of 363
pro vyhledávání: '"David A Wink"'
Publikováno v:
Molecules, Vol 24, Iss 20, p 3722 (2019)
Nitric oxide (NO) is implicated in several biological processes, including cancer progression. At low concentrations, it promotes cell survival and tumor progression, and at high concentrations it causes apoptosis and cell death. Until now, the impac
Externí odkaz:
https://doaj.org/article/0b7f93c3ddd1460b9adcff2d4b32f3bb
Autor:
Lisa A Ridnour, Kimberly M Barasch, Alisha N Windhausen, Tiffany H Dorsey, Michael M Lizardo, Harris G Yfantis, Dong H Lee, Christopher H Switzer, Robert Y S Cheng, Julie L Heinecke, Ernst Brueggemann, Harry B Hines, Chand Khanna, Sharon A Glynn, Stefan Ambs, David A Wink
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44081 (2012)
Prediction of therapeutic response and cancer patient survival can be improved by the identification of molecular markers including tumor Akt status. A direct correlation between NOS2 expression and elevated Akt phosphorylation status has been observ
Externí odkaz:
https://doaj.org/article/5a65063fd7054d7e9e1b11657caa0e77
Autor:
Jane J Sohn, Aaron J Schetter, Harris G Yfantis, Lisa A Ridnour, Izumi Horikawa, Mohammed A Khan, Ana I Robles, S Perwez Hussain, Akiteru Goto, Elise D Bowman, Lorne J Hofseth, Jirina Bartkova, Jiri Bartek, Gerald N Wogan, David A Wink, Curtis C Harris
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44156 (2012)
BACKGROUND:Cellular senescence can be a functional barrier to carcinogenesis. We hypothesized that inflammation modulates carcinogenesis through senescence and DNA damage response (DDR). We examined the association between senescence and DDR with mac
Externí odkaz:
https://doaj.org/article/77068782f8484d4388da497fddb461d0
Autor:
Erika M. Palmieri, Ronald Holewinski, Christopher L. McGinity, Ciro L. Pierri, Nunziata Maio, Jonathan M. Weiss, Vincenzo Tragni, Katrina M. Miranda, Tracey A. Rouault, Thorkell Andresson, David A. Wink, Daniel W. McVicar
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract M1 macrophages enter a glycolytic state when endogenous nitric oxide (NO) reprograms mitochondrial metabolism by limiting aconitase 2 and pyruvate dehydrogenase (PDH) activity. Here, we provide evidence that NO targets the PDH complex by usi
Externí odkaz:
https://doaj.org/article/c6b5815c95e344bdaaa97f1c13a3f7f7
Autor:
Robert Y. S. Cheng, Lisa A. Ridnour, Adelaide L. Wink, Ana L. Gonzalez, Elise L. Femino, Helene Rittscher, Veena Somasundaram, William F. Heinz, Leandro Coutinho, M. Cristina Rangel, Elijah F. Edmondson, Donna Butcher, Robert J. Kinders, Xiaoxian Li, Stephen T. C. Wong, Daniel W. McVicar, Stephen K. Anderson, Milind Pore, Stephen M. Hewitt, Timothy R. Billiar, Sharon A. Glynn, Jenny C. Chang, Stephen J. Lockett, Stefan Ambs, David A. Wink
Publikováno v:
Cell Death and Disease, Vol 14, Iss 5, Pp 1-12 (2023)
Abstract A strong correlation between NOS2 and COX2 tumor expression and poor clinical outcomes in ER breast cancer has been established. However, the mechanisms of tumor induction of these enzymes are unclear. Analysis of The Cancer Genome Atlas (TC
Externí odkaz:
https://doaj.org/article/5046eefbdac54f9198343a6b6f842146
Autor:
Caroline Andrews, Mairi H. McLean, Julie A. Hixon, Sergio M. Pontejo, Tregei Starr, Courtney Malo, Margaret Cam, Lisa Ridnour, Heather Hickman, Olivia Steele-Mortimer, David A. Wink, Howard A. Young, Daniel W. McVicar, Wenqing Li, Scott K. Durum
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Mucosal delivery of IL-27 has been shown to have a therapeutic benefit in murine models of inflammatory bowel disease (IBD). The IL-27 effect was associated with phosphorylated STAT1 (pSTAT1), a product of IL27 receptor signaling, in bowel tissue. To
Externí odkaz:
https://doaj.org/article/63471c5b8e93457bbc461734fa452b98
Autor:
Mayumi Fujita, Kaori Imadome, Veena Somasundaram, Miki Kawanishi, Kumiko Karasawa, David A. Wink
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)
Abstract Background Metabolic reprogramming is being recognized as a fundamental hallmark of cancer, and efforts to identify drugs that can target cancer metabolism are underway. In this study, we used human breast cancer (BC) cell lines and establis
Externí odkaz:
https://doaj.org/article/3565cba2388648eea80726aef3476fb6
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 311 (2023)
The small endogenous signaling molecule nitric oxide (NO) has been linked with chronic inflammation and cancer. The effects of NO are both concentration and temporally dependent; under some conditions, NO protects against damage caused by reactive ox
Externí odkaz:
https://doaj.org/article/2bc5c4e1e30346049eb87ead683ae691
Autor:
Florêncio Sousa Gouveia Júnior, João Alison de Moraes Silveira, Thais Muratori Holanda, Aline Diogo Marinho, Lisa A. Ridnour, David A. Wink, Rodrigo José Bezerra de Siqueira, Helena Serra Azul Monteiro, Eduardo Henrique Silva de Sousa, Luiz Gonzaga de França Lopes
Publikováno v:
Dalton Transactions. 52:5176-5191
New ruthenium nitrosyl complexes were synthesized and characterized by spectroscopic techniques, including X-ray absorption. Under selected conditions, they were able to release NO and HNO, which was demonstrated through in vitro cell assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acd64c576701e1abaa47aef2e90edd56
https://doi.org/10.1039/d3dt00059a
https://doi.org/10.1039/d3dt00059a
Autor:
Veena Somasundaram, Anne C. Gilmore, Debashree Basudhar, Erika Mariana Palmieri, David A. Scheiblin, William F. Heinz, Robert.Y.S. Cheng, Lisa A. Ridnour, Grégoire Altan-Bonnet, Stephen J. Lockett, Daniel W. McVicar, David A. Wink
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
The role of nitric oxide (NO) in cancer progression has largely been studied in the context of tumor NOS2 expression. However, pro- versus anti-tumor signaling is also affected by tumor cell-macrophage interactions. While these cell-cell interactions
Externí odkaz:
https://doaj.org/article/e9a5ee25069b4219b610c262682be9b9