Zobrazeno 1 - 10
of 22
pro vyhledávání: '"David A Whipple"'
Autor:
Xinbo Luo, Bart Lutterbach, Priya Pancholi, Yeon Sook Choi, Xiao Liu, Phillip Munson, Saqib Faisal, David A. Whipple, Robert A. Smith, Warren S. Weiner, David K. Johnson, Myriam Boukhali, Nicole S. Persky, Matthew G. Rees, Shunsuke Kitajima, David Barbie, Anuradha Roy, Michael Baltezor, Lian Rajewski, William McGuinness, John Haslam, Ananthan Sadagopan, Charles H. Yoon, Cory M. Johannessen, Christine G. Lian, Jason L. Hornick, Srinivas R. Viswanathan, David Liu, Vicki Nienaber, Wilhelm Haas, Frank J. Schoenen, David E. Fisher, Rizwan Haq
Publikováno v:
Cancer Research. 83:1706-1706
The transcription factor NRF2 is a master regulator of cellular responses to oxidative stress, contributing to the pathogenesis of autoimmunity, metabolic disorders, and neurodegeneration. Somatic alterations in the NRF2 pathway also contribute to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0e04d0b7c12a4af9fee06850f1e9b16
https://doi.org/10.1158/1538-7445.am2023-1706
https://doi.org/10.1158/1538-7445.am2023-1706
Autor:
Daljit S. Matharu, Baozong Li, Siobhan Malany, Frank J. Schoenen, Chen-Ting Ma, Yi-Jia Li, Ramir Vega, Qing Sun, Yifei Li, Thomas D.Y. Chung, Brian S. J. Blagg, Danielle Key, Aileen Y. Alontaga, Chih-Hong Chen, Eduard Sergienko, Yuan Chen, David A Whipple
Publikováno v:
ACS Combinatorial Science. 17:239-246
Protein-protein interactions are generally challenging to target by small molecules. To address the challenge, we have used a multi-disciplinary approach to identify small-molecule disruptors of protein-protein interactions that are mediated by SUMO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b05f3c894d7a4694f0bd8abd499eb7b
https://doi.org/10.1021/co500181b
https://doi.org/10.1021/co500181b
Autor:
Brett M. Lillie, Matthew Frank Brown, Bret D. Perry, Mark Edward Flanagan, Chakrapani Subramanyam, Kudlacz Elizabeth M, Jianmin Sun, Michael B. Fisher, Todd Andrew Blumenkopf, Chang Shang-Poa, Perry S. Sawyer, Timothy J. Strelevitz, Sandra P. McCurdy, William H. Brissette, Craig R. Kent, Paul S. Changelian, Jonathan L. Doty, Michael John Munchhof, David A Whipple, Jeffrey M. Casavant, Michael Hines, Kelly S. Magnuson, Eileen A. Elliott
Publikováno v:
Journal of Medicinal Chemistry. 53:8468-8484
There is a critical need for safer and more convenient treatments for organ transplant rejection and autoimmune disorders such as rheumatoid arthritis. Janus tyrosine kinases (JAK1, JAK3) are expressed in lymphoid cells and are involved in the signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8b2178a892e219d40a9e1abea75681
https://doi.org/10.1021/jm1004286
https://doi.org/10.1021/jm1004286
Autor:
Deborah Finco-Kent, Panayiotis Zagouras, James F. Smith, Kwansik Yoon, Douglas A. Fisher, Randall E. Morris, Jeffrey M. Casavant, Eileen A. Elliott, Dominic C. Borie, William H. Martin, Craig R. Kent, Paul S. Changelian, Linda F. Nelms, John J. O'Shea, Bonnie J. Rizzuti, Anthony J. Milici, Sandra P. McCurdy, Bret D. Perry, Todd Andrew Blumenkopf, Michael John Munchhof, John P. Higgins, Ming-Sing Si, Michael J Larson, William H. Brissette, Chakrapani Subramanyam, Thasia G. Woodworth, Timothy J. Strelevitz, John L. Doty, Bari Holm, Mark Edward Flanagan, Mary Josephine Saltarelli, Gretchen E Beckius, Chunyan Su, Ricardo T. Paniagua, Michael Hines, Chan R. Beals, Johnson Kimberly Sue, Maryrose J. Conklyn, Bruce H. Littman, Kelly S. Magnuson, Holly A. Magna, Perry S. Sawyer, Bruce A. Reitz, Brett M. Lillie, Lisa S. Hayes, Kudlacz Elizabeth M, David A. Whipple, James D. Moyer, Erika R. Koslov, Jianmin Sun, Matthew Frank Brown, Anderson See Gaweco, Yong Jie Zhou, Chang Shang-Poa, Deanna L. Baker, Thomas T. Kawabata, Shelley G. des Etages, Michael B. Fisher, Douglas J. Ball
Publikováno v:
Science. 302:875-878
Because of its requirement for signaling by multiple cytokines, Janus kinase 3 (JAK3) is an excellent target for clinical immunosuppression. We report the development of a specific, orally active inhibitor of JAK3, CP-690,550, that significantly prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea15b17ccaadc6b33998089ee820ac1d
https://doi.org/10.1126/science.1087061
https://doi.org/10.1126/science.1087061
Development of a Scaleable Route for the Production of cis-N-Benzyl-3-methylamino-4-methylpiperidine
Autor:
Wilcox Glenn Ernest, Weiling Cai, Mark Edward Flanagan, Stefan Abele, Jeffrey M. Casavant, Mike Munchhoff, David H. Brown Ripin, Ton Vries, David A. Whipple, Kees Pouwer, Cliff Meltz, Jianmin Sun, Keith E. McCarthy, Klaus Laue, John J. Teixeira, Christian Koecher, Jonathan L. Doty, Bharat Kiritkumar Shah, Todd Andrew Blumenkopf
Publikováno v:
Organic Process Research & Development. 7:115-120
The synthesis of cis-N-benzyl-3-methylamino-4-methylpiperidine (5) via hydroboration of tetrahydropyridine 3 followed by oxidation and reductive amination was optimized and scaled up to produce 10-kg quantities of product. Three routes to 3 were iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d4c02f223cd1ebe05d57ff7969d746b
https://doi.org/10.1021/op025599x
https://doi.org/10.1021/op025599x
Autor:
Stephen R. Slauson, Thomas E. Prisinzano, Lei Zhou, Jeffrey Aubé, John M. Streicher, David A Whipple, Kevin J. Frankowski, Kimberly M. Lovell, Angela Phillips, Frank J. Schoenen, Laura M. Bohn
Publikováno v:
Bioorganicmedicinal chemistry. 23(14)
Optimization of the sulfonamide-based kappa opioid receptor (KOR) antagonist probe molecule ML140 through constraint of the sulfonamide nitrogen within a tetrahydroisoquinoline moiety afforded a marked increase in potency. This strategy, when combine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83b9cb87680d511fd72f626f5e3d80eb
https://pubmed.ncbi.nlm.nih.gov/25593096
https://pubmed.ncbi.nlm.nih.gov/25593096
Autor:
Tina S. Skinner-Adams, Frank J. Schoenen, Patrick Porubsky, John P. Dalton, Louis Scampavia, Jenna L. Wang, Timothy P. Spicer, Fabio L. da Silva, Partha Ghosh, Peter Hodder, Donald L. Gardiner, David A Whipple, Christopher L. Brown, Joyce To, Katharine R. Trenholme, Peter Chase, Virneliz Fernandez-Vega
The target of this study, the PfM18 aspartyl aminopeptidase (PfM18AAP), is the only AAP present in the genome of the malaria parasite Plasmodium falciparum. PfM18AAP is a metallo-exopeptidase that exclusively cleaves N-terminal acidic amino acids glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a50a2b62939ef7d3beb28ef902d63394
https://hdl.handle.net/10453/116033
https://hdl.handle.net/10453/116033
Autor:
David G. Perregaux, Perry S. Sawyer, Mark Edward Flanagan, Michael John Munchhof, Kelly S. Magnuson, Jonathan L. Doty, Craig R. Kent, Paul S. Changelian, Thomas M. Harris, Jianmin Sun, David A. Whipple, Cyrille Kuhn, Kudlacz Elizabeth M, Deborah J. Moshinsky
Publikováno v:
Blood. 111:2155-2157
PF-956980 is a selective inhibitor of JAK3, related in structure to CP-690550, a compound being evaluated in clinical trials for rheumatoid arthritis and prevention of allograft rejection. PF-956980 has been evaluated against a panel of 30 kinases, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f2de0ea859bf3e0d4c38ae35781418
https://doi.org/10.1182/blood-2007-09-115030
https://doi.org/10.1182/blood-2007-09-115030
Autor:
David O. Whipple, Judith S. Wolverton, Christopher L. Morton, Philip M. Potter, Mary K. Danks
Publikováno v:
Cytometry. 32:223-232
Carboxylesterases are a ubiquitous class of enzymes thought to be involved in xenobiotic metabolism and detoxification. Primary amino acid sequence data suggest that these proteins localize to the endoplasmic reticulum. However, since this family of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::125f3327a3e3626abfe489bc6c1dcc8b
https://doi.org/10.1002/(sici)1097-0320(19980701)32:3<223::aid-cyto9>3.0.co
https://doi.org/10.1002/(sici)1097-0320(19980701)32:3<223::aid-cyto9>3.0.co
Publikováno v:
Communications in Statistics - Theory and Methods. 27:1419-1432
In this article, the Food and Drug Administration's (FDA) medical device substantial equivalence provision will be briefly introduced and some statistical methods useful for evaluating device equivalence are discussed. A sample size formula is derive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d411946fb2ed6bfbd87f8d5ff101b86b
https://doi.org/10.1080/03610929808832167
https://doi.org/10.1080/03610929808832167