Inhibition of SARS-CoV-2 growth in the lungs of mice by a peptide-conjugated morpholino oligomer targeting viral RNA

Autor: Alexandra Sakai, Gagandeep Singh, Mahsa Khoshbakht, Scott Bittner, Christiane V. Löhr, Randy Diaz-Tapia, Prajakta Warang, Kris White, Luke Le Luo, Blanton Tolbert, Mario Blanco, Amy Chow, Mitchell Guttman, Cuiping Li, Yiming Bao, Joses Ho, Sebastian Maurer-Stroh, Arnab Chatterjee, Sumit Chanda, Adolfo García-Sastre, Michael Schotsaert, John R. Teijaro, Hong M. Moulton, David A. Stein

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102331- (2024)

Further development of direct-acting antiviral agents against human SARS-CoV-2 infections remains a public health priority. Here, we report that an antisense peptide-conjugated morpholino oligomer (PPMO) named 5′END-2, targeting a highly conserved

Externí odkaz: https://doaj.org/article/cde8602c5de243599a35a2d086e74e3b

Unveiling the Role of TMPRSS2 in the Proteolytic Activation of Pandemic and Zoonotic Influenza Viruses and Coronaviruses in Human Airway Cells

Autor: Marie Schwerdtner, Luna C. Schmacke, Julia Nave, Hannah Limburg, Torsten Steinmetzer, David A. Stein, Hong M. Moulton, Eva Böttcher-Friebertshäuser

Publikováno v: Viruses, Vol 16, Iss 11, p 1798 (2024)

The zoonotic transmission of influenza A viruses (IAVs) and coronaviruses (CoVs) may result in severe disease. Cleavage of the surface glycoproteins hemagglutinin (HA) and spike protein (S), respectively, is essential for viral infectivity. The trans

Externí odkaz: https://doaj.org/article/b9d683346e0040d5b78dbc6365d841b1

Monoclonal War: The Antibody Arsenal and Targets for Expanded Application

Autor: Eric H. Rosenn, Mickael Benhaim, Allison Siegel, David A. Stein, Joseph S. Leonard, Erik Katcher, Dania Halperin, Zachary Mostel

Publikováno v: Immuno, Vol 3, Iss 3, Pp 346-357 (2023)

Advancements in sequencing and screening technology have made monoclonal antibodies more accessible, cost-effective, and precise. These drugs effectively target pathogens and cancer cells and even regulate metabolic pathways by focusing on specific i

Externí odkaz: https://doaj.org/article/a83910fa4ad9430598b3ef8f1bf4d8af

Self-organized intracellular twisters

Autor: Sayantan Dutta, Reza Farhadifar, Wen Lu, Gokberk Kabacaoğlu, Robert Blackwell, David B. Stein, Margot Lakonishok, Vladimir I. Gelfand, Stanislav Y. Shvartsman, Michael J. Shelley

Life in complex systems, such as cities and organisms, comes to a standstill when global coordination of mass, energy, and information flows is disrupted. Global coordination is no less important in single cells, especially in large oocytes and newly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57141f5707f5b5bdbce0a12457ec9f5
https://doi.org/10.1101/2023.04.04.534476

List of contributors

Autor: Arad Abadi, Sherwin Abdoli, Benjamin Acton, Alexandra M. Adams, Aderinsola A. Aderonmu, Rakesh Ahuja, Saleh Aiyash, Gabriel Akopian, Benjamin G. Allar, Michael F. Amendola, Taylor Anderson, Athena Andreadis, Darwin N. Ang, Ersilia Anghel, Favour Mfonobong Anthony, Precious Idorenyin Anthony, Jordan C. Apfeld, Youssef Aref, Fernando D. Arias, Margaret Arnold, Abbasali Badami, Jeffrey Alexander Bakal, Varun V. Bansal, J. Barney, Jessica Barson, Lauren L. Beck, Andrew R. Bender, Vivek Bhat, Saptarshi Biswas, David Blitzer, Tayt Boeckholt, John S. Bolton, Sourav K. Bose, Gerald M. Bowers, Mary E. Brindle, Matthew A. Brown, F. Charles Brunicardi, Richard A. Burkhart, Jennifer L. Byk, M. Campbell, Danilea M. Carmona Matos, Kenny J. Castro-Ochoa, Juan Cendan, Shane Charles, Angel D. Chavez-Rivera, Hao Wei Chen, Herbert Chen, Kevin Chen, Wendy Chen, Darren C. Cheng, Nicole B. Cherng, Christina Shree Chopra, G. Travis Clifton, Jason Crowner, Houston Curtis, Temilolaoluwa O. Daramola, Aria Darbandi, Serena Dasani, Kaci DeJarnette, Jeremiah Deneve, Karuna Dewan, Marcus Dial, Jody C. DiGiacomo, Andrew L. DiMatteo, Tsering Y. Dirkhipa, James M. Dittman, Ashley C. Dodd, Israel Dowlat, Hans E. Drawbert, Juan Duchesne, Omar Elfanagely, Yousef Elfanagely, Javed Khader Eliyas, Chukwuma N. Eruchalu, James C. Etheridge, Erfan Faridmoayer, Arjumand Faruqi, Jessica Dominique Feliz, Martin D. Fleming, Laura M. Fluke, Jason M. Flynn, Kathryn L. Fowler, Miguel Garcia, Tushar Garg, Patrick C. Gedeon, Ruby Gilmor, Julie Goldman, Christian Gonzalez, Rachael E. Guenter, Brian C. Gulack, Matthew Handmacher, Ivy N. Haskins, Carl Haupt, Kshipra Hemal, Matthew T. Hey, Perez Holguin, Christopher S. Hollenbeak, Andrew Holmes, Hyo Jung Hong, Nicholas Huerta, Mohamad A. Hussain, Yaritza Inostroza-Nieves, Marc J. Kahn, Sunil S. Karhadkar, Mohammed A. Kashem, Qingwen Kawaji, Syed Faraz Kazim, Kathryn C. Kelley, Monty U. Khajanchi, Shaarif Rauf Khan, Quynh Kieu, Charissa Kim, Roger Klein, Suzanne Kool, Jessica S. Kruger, Afif N. Kulaylat, Audrey S. Kulaylat, Elizabeth Laikhter, Samuel Lance, Megan LeBlanc, David Lee, Frank V. Lefevre, Jacob Levy, Deacon J. Lile, Carol A. Lin, Xinyi Luo, David A. Machado-Aranda, Kashif Majeed, Madhu Mamidala, Nizam Mamode, Abhishek Mane, Samuel M. Manstein, Jenna Maroney, Jessica Maxwell, Patrick M. McCarthy, Philip McCarthy, Hector Mejia, Pallavi Menon, Albert Moeller, Dennis Spalla Morris, Haley Nadone, Anil Nanda, Allison Nauta, Matthew Navarro, Daniel W. Nelson, Daniel C. Neubauer, Kaitlin A. Nguyen, Louis L. Nguyen, Katherine Nielson, Austin O. McCrea, Delia S. Ocaña Narváez, Peter Oro, Gezzer Ortega, Adena J. Osband, Ahmad Ozair, Rohan Palanki, Jaime Pardo Palau, Juliet Panichella, Panini Patankar, Aneri Patel, Nirmit Patel, Gehan A. Pendlebury, Christina Poa-Li, Sangeetha Prabhakaran, Hashir Qamar, Ramesh Raghupathi, Faique Rahman, Mohan Ramalingam, Syed S. Razi, Aminah Abdul Razzack, Abdul Razzaq, Amanda J. Reich, Christopher Reid, Clay Resweber, Mark Riddle, Mehida Rojas-Alexandre, Susan Rowell, Vanessa Roxo, Debosree Roy, Jacqueline L. Russell, Mala Sachdev, Ruben D. Salas-Parra, Ali Salim, John H. Sampson, Andrea Valquiria Sanchez, Tiffany R. Sanchez, Jane R. Schubart, C. Schwartz, Alexander Schwartzman, Erin M. Scott, Ali Seifi, Aditya Sekhani, Chan Shen, Eric Shiah, Jeffrey W. Shupp, Meaghan Sievers, Rachel E. Silver, Kirit Singh, Robert D. Sinyard, Kevin L. Smith, Tandis Soltani, Abhinav Arun Sonkar, Dallas J. Soyland, Mackinzie A. Stanley, David E. Stein, Sean C. Stuart, Linh Tran, Andrew Vierra, Vanessa M. Welten, Kate Whelihan, Brandon M. White, Rebecca L. Williams-Karnesky, Emily E. Witt, Heather X. Rhodes, Seiji Yamaguchi, Ravali Yenduri, Andrew Yiu, Benjamin R. Zambetti, Christa Zino, Haley A. Zlomke

Publikováno v: Translational Surgery ISBN: 9780323903004

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc6b6c18e831339ac71fb91af53011b7
https://doi.org/10.1016/b978-0-323-90300-4.01002-8