Výsledky vyhledávání - "David A Rubenstein"

Akademický článek

Electronic cigarette aerosols suppress cellular antioxidant defenses and induce significant oxidative DNA damage.

Autor: Vengatesh Ganapathy, Jimmy Manyanga, Lacy Brame, Dehra McGuire, Balaji Sadhasivam, Evan Floyd, David A Rubenstein, Ilangovan Ramachandran, Theodore Wagener, Lurdes Queimado

Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0177780 (2017)

Electronic cigarette (EC) aerosols contain unique compounds in addition to toxicants and carcinogens traditionally found in tobacco smoke. Studies are warranted to understand the public health risks of ECs.The aim of this study was to determine the g

Externí odkaz: https://doaj.org/article/1480f8c6c7fb47f4a159313b89e03822

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Akademický článek

Rapid Improvements in Itch with Tapinarof Cream 1% Once Daily in Two Phase 3 Trials in Adults with Mild to Severe Plaque Psoriasis

Autor: Leon Kircik, Matthew Zirwas, Shawn G. Kwatra, G. Michael Lewitt, Holly Glover, Tomas Chao, Philip M. Brown, David S. Rubenstein, Anna M. Tallman

Publikováno v: Dermatology and Therapy, Vol 14, Iss 1, Pp 201-211 (2023)

Abstract Introduction Patients with psoriasis report pruritus as their most bothersome symptom. Tapinarof cream 1% once daily demonstrated significant efficacy versus vehicle and was well tolerated in adults with mild to severe plaque psoriasis in tw

Externí odkaz: https://doaj.org/article/2c5d9e4972684e8faa868f89e77d9aad

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Akademický článek

Tapinarof Cream 1% Once Daily for the Treatment of Plaque Psoriasis: Case Photography of Clinical Outcomes from Three Phase 3 Trials

Autor: Seemal R. Desai, Linda Stein Gold, Michael C. Cameron, Alexandra Golant, G. Michael Lewitt, Matthew J. Bruno, George Martin, Philip M. Brown, David S. Rubenstein, Victoria Butners, Anna M. Tallman

Publikováno v: Dermatology and Therapy, Vol 13, Iss 10, Pp 2443-2460 (2023)

Abstract Tapinarof cream 1% (VTAMA®; Dermavant Sciences, Inc.) is a non-steroidal, topical, aryl hydrocarbon receptor agonist approved by the US Food and Drug Administration (FDA) to treat plaque psoriasis in adults and under investigation for the t

Externí odkaz: https://doaj.org/article/765499add9ea47908d1b15a7a34f1ce3

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Akademický článek

An in situ inferior vena cava ligation-stenosis model to study thrombin generation rates with flow

Autor: Wei Yin, Andrew Dimatteo, Andrew Kumpfbeck, Stephen Leung, Marina Fandaros, Bryan Musmacker, David A. Rubenstein, Mary D. Frame

Publikováno v: Thrombosis Journal, Vol 20, Iss 1, Pp 1-9 (2022)

Abstract Background Blood flow-induced shear stress affects platelet participation in coagulation and thrombin generation. We aimed to develop an in vivo model to characterize thrombin generation rates under flow. Methods An in situ inferior vena cav

Externí odkaz: https://doaj.org/article/4f1d7f9bcf5d403387670eaa4a9779ce

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Akademický článek

Complement component C1q initiates extrinsic coagulation via the receptor for the globular head of C1q in adventitial fibroblasts and vascular smooth muscle cells

Autor: Christopher T. Freda, Wei Yin, Berhane Ghebrehiwet, David A. Rubenstein

Publikováno v: Immunity, Inflammation and Disease, Vol 11, Iss 1, Pp n/a-n/a (2023)

Abstract Background Vascular diseases are highly associated with inflammation and thrombosis. Elucidating links between these two processes may provide a clearer understanding of these diseases, allowing for the design of more effective treatments. T

Externí odkaz: https://doaj.org/article/5bee9b5090324b00b2abbf82805c6dbc

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Akademický článek

SARS-CoV-2 Exacerbates COVID-19 Pathology Through Activation of the Complement and Kinin Systems

Autor: Anne G. Savitt, Samantha Manimala, Tiara White, Marina Fandaros, Wei Yin, Huiquan Duan, Xin Xu, Brian V. Geisbrecht, David A. Rubenstein, Allen P. Kaplan, Ellinor I. Peerschke, Berhane Ghebrehiwet

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Infection with SARS-CoV-2 triggers the simultaneous activation of innate inflammatory pathways including the complement system and the kallikrein-kinin system (KKS) generating in the process potent vasoactive peptides that contribute to severe acute

Externí odkaz: https://doaj.org/article/6770e2f74e8948b8a62d2b8fa28fe7c4

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Akademický článek

Glycated albumin modifies platelet adhesion and aggregation responses

Autor: Ioana Soaita, Wei Yin, David A. Rubenstein

Publikováno v: Platelets, Vol 28, Iss 7, Pp 682-690 (2017)

A diabetic vasculature is detrimental to cardiovascular health through the actions of advanced glycation end products (AGEs) on endothelial cells and platelets. Platelets activated by AGEs agonize endothelial responses promoting cardiovascular diseas

Externí odkaz: https://doaj.org/article/e1d9593328c246398d871914025b6f19

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