Zobrazeno 1 - 10
of 2 075
pro vyhledávání: '"David A Price"'
Autor:
Mathew Clement, Kristin Ladell, Kelly L Miners, Morgan Marsden, Lucy Chapman, Anna Cardus Figueras, Jake Scott, Robert Andrews, Simon Clare, Valeriia V Kriukova, Ksenia R Lupyr, Olga V Britanova, David R Withers, Simon A Jones, Dmitriy M Chudakov, David A Price, Ian R Humphreys
Publikováno v:
eLife, Vol 12 (2023)
Inhibitory CD4+ T cells have been linked with suboptimal immune responses against cancer and pathogen chronicity. However, the mechanisms that underpin the development of these regulatory cells, especially in the context of ongoing antigen exposure,
Externí odkaz:
https://doaj.org/article/2ebd05a7a8214cc583977dd47ed817fc
Autor:
Ceri Alan Fielding, Pragati Sabberwal, James C Williamson, Edward JD Greenwood, Thomas WM Crozier, Wioleta Zelek, Jeffrey Seow, Carl Graham, Isabella Huettner, Jonathan D Edgeworth, David A Price, Paul B Morgan, Kristin Ladell, Matthias Eberl, Ian R Humphreys, Blair Merrick, Katie Doores, Sam J Wilson, Paul J Lehner, Eddie CY Wang, Richard J Stanton
Publikováno v:
eLife, Vol 11 (2022)
The outcome of infection is dependent on the ability of viruses to manipulate the infected cell to evade immunity, and the ability of the immune response to overcome this evasion. Understanding this process is key to understanding pathogenesis, genet
Externí odkaz:
https://doaj.org/article/dac3657f8bfc48e98d71a0036c060efa
Autor:
Sofya A Kasatskaya, Kristin Ladell, Evgeniy S Egorov, Kelly L Miners, Alexey N Davydov, Maria Metsger, Dmitry B Staroverov, Elena K Matveyshina, Irina A Shagina, Ilgar Z Mamedov, Mark Izraelson, Pavel V Shelyakin, Olga V Britanova, David A Price, Dmitriy M Chudakov
Publikováno v:
eLife, Vol 9 (2020)
The organizational integrity of the adaptive immune system is determined by functionally discrete subsets of CD4+ T cells, but it has remained unclear to what extent lineage choice is influenced by clonotypically expressed T-cell receptors (TCRs). To
Externí odkaz:
https://doaj.org/article/1dd049e96e1b4c82816146e92ae81118
Autor:
Frances E Pearson, Kirsteen M Tullett, Ingrid M Leal‐Rojas, Oscar L Haigh, Kelly‐Anne Masterman, Carina Walpole, John S Bridgeman, James E McLaren, Kristin Ladell, Kelly Miners, Sian Llewellyn‐Lacey, David A Price, Antje Tunger, Marc Schmitz, John J Miles, Mireille H Lahoud, Kristen J Radford
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 6, Pp n/a-n/a (2020)
Abstract Objectives Vaccines that prime Wilms' tumor 1 (WT1)‐specific CD8+ T cells are attractive cancer immunotherapies. However, immunogenicity and clinical response rates may be enhanced by delivering WT1 to CD141+ dendritic cells (DCs). The C
Externí odkaz:
https://doaj.org/article/d7716a6649ca41f9a6290ec9da9eae79
Autor:
Qianqian Ming, Daniel Antfolk, David A. Price, Anna Manturova, Elliot Medina, Srishti Singh, Charlotte Mason, Timothy H. Tran, Keiran S. M. Smalley, Daisy W. Leung, Vincent C. Luca
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The immune checkpoint protein, Lymphocyte activation gene-3 (LAG3), binds Major Histocompatibility Complex Class II (MHC-II) and suppresses T cell activation. Despite the recent FDA approval of a LAG3 inhibitor for the treatment of melanoma,
Externí odkaz:
https://doaj.org/article/7b12d9f7a4494fceb98b9a25a6dc0b12
Autor:
Guy E Thwaites, Matthew Scarborough, Alexander Szubert, Pedro Saramago Goncalves, Marta Soares, Jennifer Bostock, Emmanuel Nsutebu, Robert Tilley, Richard Cunningham, Julia Greig, Sarah A Wyllie, Peter Wilson, Cressida Auckland, Janet Cairns, Denise Ward, Pankaj Lal, Achyut Guleri, Neil Jenkins, Julian Sutton, Martin Wiselka, Gonzalez-Ruiz Armando, Clive Graham, Paul R Chadwick, Gavin Barlow, N Claire Gordon, Bernadette Young, Sarah Meisner, Paul McWhinney, David A Price, David Harvey, Deepa Nayar, Dakshika Jeyaratnam, Timothy Planche, Jane Minton, Fleur Hudson, Susan Hopkins, John Williams, M Estee Török, Martin J Llewelyn, Jonathan D Edgeworth, A Sarah Walker
Publikováno v:
Health Technology Assessment, Vol 22, Iss 59 (2018)
Background: Staphylococcus aureus bacteraemia is a common and frequently fatal infection. Adjunctive rifampicin may enhance early S. aureus killing, sterilise infected foci and blood faster, and thereby reduce the risk of dissemination, metastatic in
Externí odkaz:
https://doaj.org/article/6ed53dee06594dd7824bb5a8cdc31e4b
Autor:
Pedro Costa Del Amo, Julio Lahoz-Beneytez, Lies Boelen, Raya Ahmed, Kelly L Miners, Yan Zhang, Laureline Roger, Rhiannon E Jones, Silvia A Fuertes Marraco, Daniel E Speiser, Duncan M Baird, David A Price, Kristin Ladell, Derek Macallan, Becca Asquith
Publikováno v:
PLoS Biology, Vol 16, Iss 6, p e2005523 (2018)
Adaptive immunity relies on the generation and maintenance of memory T cells to provide protection against repeated antigen exposure. It has been hypothesised that a self-renewing population of T cells, named stem cell-like memory T (TSCM) cells, are
Externí odkaz:
https://doaj.org/article/c85bfaa7e2db4200835697b9df1f03c9
Autor:
Daniel J Laydon, Anat Melamed, Aaron Sim, Nicolas A Gillet, Kathleen Sim, Sam Darko, J Simon Kroll, Daniel C Douek, David A Price, Charles R M Bangham, Becca Asquith
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 6, p e1003646 (2014)
Estimation of immunological and microbiological diversity is vital to our understanding of infection and the immune response. For instance, what is the diversity of the T cell repertoire? These questions are partially addressed by high-throughput seq
Externí odkaz:
https://doaj.org/article/ad677c031f1d44218112b0e1e156115c
Autor:
Anat Melamed, Aviva D Witkover, Daniel J Laydon, Rachael Brown, Kristin Ladell, Kelly Miners, Aileen G Rowan, Niall Gormley, David A Price, Graham P Taylor, Edward L Murphy, Charles R M Bangham
Publikováno v:
PLoS Pathogens, Vol 10, Iss 3, p e1004006 (2014)
Human T-lymphotropic virus type 1 (HTLV-1) and type 2 (HTLV-2) both cause lifelong persistent infections, but differ in their clinical outcomes. HTLV-1 infection causes a chronic or acute T-lymphocytic malignancy in up to 5% of infected individuals w
Externí odkaz:
https://doaj.org/article/cc85db44a5e248c49c56084f02d7ee82
Autor:
Hugo Antonius van den Berg, Kristin eLadell, Kelly eMiners, Bruno eLaugel, Sian eLlewellyn-Lacey, Mathew eClement, David K Cole, Emma eGostick, Linda eWooldridge, Andrew Kelvin Sewell, John Stephen Bridgeman, David A Price
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
Peptide-MHC (pMHC) ligand engagement by T-cell receptors (TCRs) elicits a variety of cellular responses, some of which require substantially more TCR-mediated stimulation than others. This threshold hierarchy could reside at the receptor level, where
Externí odkaz:
https://doaj.org/article/c3570d2cea314a2187180619c9cbec4f