Zobrazeno 1 - 10
of 1 059
pro vyhledávání: '"David A Owen"'
Autor:
Andrew C Nyborg, Chris Ward, Anna Zacco, Benoy Chacko, Luba Grinberg, James C Geoghegan, Ryan Bean, Michaela Wendeler, Frank Bartnik, Ellen O'Connor, Flaviu Gruia, Vidyashankara Iyer, Hui Feng, Varnika Roy, Mark Berge, Jeffrey N Miner, David M Wilson, Dongmei Zhou, Simone Nicholson, Clynn Wilker, Chi Y Wu, Susan Wilson, Lutz Jermutus, Herren Wu, David A Owen, Jane Osbourn, Steven Coats, Manuel Baca
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167935 (2016)
Humans and higher primates are unique in that they lack uricase, the enzyme capable of oxidizing uric acid. As a consequence of this enzyme deficiency, humans have high serum uric acid levels. In some people, uric acid levels rise above the solubilit
Externí odkaz:
https://doaj.org/article/c7112dc536a744a789e3b298aa48181d
Autor:
Stergios Tsartsalis, Hannah Sleven, Nurun Fancy, Frank Wessely, Amy M. Smith, Nanet Willumsen, To Ka Dorcas Cheung, Michal J. Rokicki, Vicky Chau, Eseoghene Ifie, Combiz Khozoie, Olaf Ansorge, Xin Yang, Marion H. Jenkyns, Karen Davey, Aisling McGarry, Robert C. J. Muirhead, Stephanie Debette, Johanna S. Jackson, Axel Montagne, David R. Owen, J. Scott Miners, Seth Love, Caleb Webber, M. Zameel Cader, Paul M. Matthews
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Brain perfusion and blood-brain barrier (BBB) integrity are reduced early in Alzheimer’s disease (AD). We performed single nucleus RNA sequencing of vascular cells isolated from AD and non-diseased control brains to characterise pathologic
Externí odkaz:
https://doaj.org/article/6d33fcf5b51e487193ad2c53717ad721
Autor:
Eric M Yoshida, R Andrew Singh, Robert K Vartanian, David A Owen, Siegfried R Erb, Charles H Scudamore
Publikováno v:
Canadian Journal of Gastroenterology, Vol 11, Iss 3, Pp 229-233 (1997)
Late recurrent primary biliary cirrhosis (PBC) following orthotopic liver transplant remains a controversial topic. The first documented case of recurrence occurring in 16 patients transplanted for PBC and followed at the authors' institution for lon
Externí odkaz:
https://doaj.org/article/1166fb45f1a44a6785f99cdec6058d49
Autor:
Alan A Weiss, David A Owen
Publikováno v:
Canadian Journal of Gastroenterology, Vol 9, Iss 7, Pp 413-416 (1995)
A 65-year-old woman who had been taking diclofenac for five years developed cramping central abdominal pain. Barium enema examination was negative, but colonoscopy revealed prominent mucosal folds in the right colon with areas of ulceration. Because
Externí odkaz:
https://doaj.org/article/91dda7df80c04e5884634bc576d61098
Autor:
Erik Nutma, Nurun Fancy, Maria Weinert, Stergios Tsartsalis, Manuel C. Marzin, Robert C. J. Muirhead, Irene Falk, Marjolein Breur, Joy de Bruin, David Hollaus, Robin Pieterman, Jasper Anink, David Story, Siddharthan Chandran, Jiabin Tang, Maria C. Trolese, Takashi Saito, Takaomi C. Saido, Katharine H. Wiltshire, Paula Beltran-Lobo, Alexandra Phillips, Jack Antel, Luke Healy, Marie-France Dorion, Dylan A. Galloway, Rochelle Y. Benoit, Quentin Amossé, Kelly Ceyzériat, Aurélien M. Badina, Enikö Kövari, Caterina Bendotti, Eleonora Aronica, Carola I. Radulescu, Jia Hui Wong, Anna M. Barron, Amy M. Smith, Samuel J. Barnes, David W. Hampton, Paul van der Valk, Steven Jacobson, Owain W. Howell, David Baker, Markus Kipp, Hannes Kaddatz, Benjamin B. Tournier, Philippe Millet, Paul M. Matthews, Craig S. Moore, Sandra Amor, David R. Owen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-25 (2023)
Abstract Microglial activation plays central roles in neuroinflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein (TSPO) is widely used for localising inflammation in vivo, but its quanti
Externí odkaz:
https://doaj.org/article/6e4226618e024c669f4f230499a8801b
Autor:
David Lloyd Owen
Publikováno v:
River, Vol 2, Iss 1, Pp 21-29 (2023)
Abstract Smart water enables utilities, regulators, and customers to make more timely and informed decisions about how they use and regard their water resources. It has been developed to assist demand management by influencing customer behavior and r
Externí odkaz:
https://doaj.org/article/041d1e960b084d069e89ce84b1ae32e5
Autor:
Mohammad Mahmud, Charles Wade, Sarah Jawad, Zaeem Hadi, Christian Otoul, Rafal M. Kaminski, Pierandrea Muglia, Irena Kadiu, Eugenii Rabiner, Paul Maguire, David R. Owen, Michael R. Johnson
Publikováno v:
Frontiers in Neuroimaging, Vol 2 (2023)
ObjectiveTranslocator protein (TSPO) targeting positron emission tomography (PET) imaging radioligands have potential utility in epilepsy to assess the efficacy of novel therapeutics for targeting neuroinflammation. However, previous studies in healt
Externí odkaz:
https://doaj.org/article/8ac866fbfb8544ee9f7ba34f2fbbf4c0
Autor:
Alex J. Szubert, Katrina M. Pollock, Hannah M. Cheeseman, Jasmini Alagaratnam, Henry Bern, Olivia Bird, Marta Boffito, Ruth Byrne, Tom Cole, Catherine A. Cosgrove, Saul N. Faust, Sarah Fidler, Eva Galiza, Hana Hassanin, Mohini Kalyan, Vincenzo Libri, Leon R. McFarlane, Ana Milinkovic, Jessica O'Hara, David R. Owen, Daniel Owens, Mihaela Pacurar, Tommy Rampling, Simon Skene, Alan Winston, James Woolley, Yee Ting N. Yim, David T. Dunn, Sheena McCormack, Robin J. Shattock
Publikováno v:
EClinicalMedicine, Vol 56, Iss , Pp 101823- (2023)
Summary: Background: Lipid nanoparticle (LNP) encapsulated self-amplifying RNA (saRNA) is well tolerated and immunogenic in SARS-CoV-2 seronegative and seropositive individuals aged 18–75. Methods: A phase 2a expanded safety and immunogenicity stud
Externí odkaz:
https://doaj.org/article/8c3e3b38ed0a4f79b89d74a152895c3b
Autor:
David Lloyd Owen
Publikováno v:
Water International. 47:1032-1036
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1de060f7d19b1412d227d5c5fb0483d4
https://doi.org/10.1080/02508060.2022.2133416
https://doi.org/10.1080/02508060.2022.2133416
Tracking Regulatory T Cell Development in the Thymus Using Single-Cell RNA Sequencing/TCR Sequencing
Publikováno v:
The Journal of Immunology. 209:1300-1313
Recent studies have demonstrated that regulatory T cells (Tregs) develop in the thymus via two pathways involving distinct Treg progenitors (TregP): CD25+FOXP3− (CD25+ TregP) and CD25−FOXP3lo (FOXP3lo TregP) Treg progenitors. To examine this proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb0ea17c2a80c35f886a2cdb649c71f
https://doi.org/10.4049/jimmunol.2200089
https://doi.org/10.4049/jimmunol.2200089