Zobrazeno 1 - 10
of 204
pro vyhledávání: '"David A Ostrov"'
Autor:
Yiran Shen, Bhuwan Khatri, Santosh Rananaware, Danmeng Li, David A Ostrov, Piyush K Jain, Christopher J Lessard, Cuong Q Nguyen
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0276700 (2023)
COVID-19 is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The severity of COVID-19 is highly variable and related to known (e.g., age, obesity, immune deficiency) and unknown risk factors. The widespread clinical symptoms en
Externí odkaz:
https://doaj.org/article/04b5c4c581934edb9ab6936c6ca5c5b7
Autor:
Katherine Sullivan, Kimberly Cramer-Morales, Daniel L McElroy, David A Ostrov, Kimberly Haas, Wayne Childers, Robert Hromas, Tomasz Skorski
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147230 (2016)
It has been reported that inhibition of RAD52 either by specific shRNA or a small peptide aptamer induced synthetic lethality in tumor cell lines carrying BRCA1 and BRCA2 inactivating mutations. Molecular docking was used to screen two chemical libra
Externí odkaz:
https://doaj.org/article/d0ce38a5e77f4bc28620ce675bd9464d
Autor:
Imir G Metushi, Amanda Wriston, Priyanka Banerjee, Bjoern Oliver Gohlke, A Michelle English, Andrew Lucas, Carrie Moore, John Sidney, Soren Buus, David A Ostrov, Simon Mallal, Elizabeth Phillips, Jeffrey Shabanowitz, Donald F Hunt, Robert Preissner, Bjoern Peters
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0124878 (2015)
Immune mediated adverse drug reactions (IM-ADRs) remain a significant source of patient morbidity that have more recently been shown to be associated with specific class I and/or II human leukocyte antigen (HLA) alleles. Abacavir-induced hypersensiti
Externí odkaz:
https://doaj.org/article/ae153d29d2504027a3260007b71c5166
Autor:
Andrew Lucas, Michaela Lucas, Anette Strhyn, Niamh M Keane, Elizabeth McKinnon, Rebecca Pavlos, Ellen M Moran, Viola Meyer-Pannwitt, Silvana Gaudieri, Lloyd D'Orsogna, Spyros Kalams, David A Ostrov, Søren Buus, Bjoern Peters, Simon Mallal, Elizabeth Phillips
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117160 (2015)
BACKGROUND:Fifty-five percent of individuals with HLA-B*57:01 exposed to the antiretroviral drug abacavir develop a hypersensitivity reaction (HSR) that has been attributed to naïve T-cell responses to neo-antigen generated by the drug. Immunologica
Externí odkaz:
https://doaj.org/article/27198fc14dec4d6ea8faa113f4e62cca
Autor:
Takashi Hamazaki, Wai-Yee Leung, Brian D Cain, David A Ostrov, Peter E Thorsness, Naohiro Terada
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19250 (2011)
The adenine nucleotide translocase (ANT) mediates the exchange of ADP and ATP across the inner mitochondrial membrane. The human genome encodes multiple ANT isoforms that are expressed in a tissue-specific manner. Recently a novel germ cell-specific
Externí odkaz:
https://doaj.org/article/85b9120e62644cf3bccb6066dffe077e
Autor:
Aruna S Jaiswal, Sanjeev Banerjee, Ritu Aneja, Fazlul H Sarkar, David A Ostrov, Satya Narayan
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16691 (2011)
Chemoprevention presents a major strategy for the medical management of colorectal cancer. Most drugs used for colorectal cancer therapy induce DNA-alkylation damage, which is primarily repaired by the base excision repair (BER) pathway. Thus, blocka
Externí odkaz:
https://doaj.org/article/51bd06a15505441292a130313298e08f
Autor:
So-Young Park, MD, PhD, So Young Park, MD, PhD, Sujin Seo, BS, Hyouk-Soo Kwon, MD, PhD, Seung-Hyun Kim, PhD, Sae-Hoon Kim, MD, PhD, Hye-Kyung Park, MD, PhD, Yoon-Seok Chang, MD, PhD, Cheol-Woo Kim, MD, PhD, Byung Jae Lee, MD, PhD, Hae-Sim Park, MD, PhD, You Sook Cho, MD, PhD, Heung-Bum Oh, PhD, David A. Ostrov, PhD, Sungho Won, PhD, Tae Bum Kim, MD, PhD
Publikováno v:
World Allergy Organization Journal, Vol 17, Iss 5, Pp 100901- (2024)
Background: Drug-induced hypersensitivity such as anaphylaxis is an important cause of drug-related morbidity and mortality. Cefaclor is a leading cause of drug induced type I hypersensitivity in Korea, but little is yet known about genetic biomarker
Externí odkaz:
https://doaj.org/article/9e7d978eac1246b4a3646cb3e8663b81
Autor:
Reed L. Berkowitz, Andrew P. Bluhm, Glenn W. Knox, Christopher R. McCurdy, David A. Ostrov, Michael H. Norris
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15718 (2023)
The emergence of lethal coronaviruses follows a periodic pattern which suggests a recurring cycle of outbreaks. It remains uncertain as to when the next lethal coronavirus will emerge, though its eventual emergence appears to be inevitable. New mutat
Externí odkaz:
https://doaj.org/article/770c90b26ad64540b160edeb0888199c
Autor:
Mubarak Almutairi, Adam Lister, Qing Zhao, James Line, Kareena Adair, Arun Tailor, James Waddington, Elsie Clarke, Joshua Gardner, Paul Thomson, Nicolas Harper, Yonghu Sun, Lele Sun, David A. Ostrov, Hong Liu, David J. MacEwan, Munir Pirmohamed, Xiaoli Meng, Furen Zhang, Dean J. Naisbitt
Publikováno v:
The Journal of Immunology. 210:1031-1042
Previous studies have shown that cysteine-reactive drug metabolites bind covalently with protein to activate patient T cells. However, the nature of the antigenic determinants that interact with HLA and whether T cell stimulatory peptides contain the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::540c34a1a67c694b21a19eb9c6f473f3
https://doi.org/10.4049/jimmunol.2200531
https://doi.org/10.4049/jimmunol.2200531
Publikováno v:
Clinica Chimica Acta. 534:71-76
It is well recognized that chronic low-grade systemic inflammation and autoimmunity contribute to the pathogenesis of metabolic syndrome, its associated diseases (e.g. type 2 diabetes, non-alcoholic fatty liver disease) and type 1 diabetes, respectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2b9fdd7d90ac8ab228ef3ed1b0ca2b
https://doi.org/10.1016/j.cca.2022.07.005
https://doi.org/10.1016/j.cca.2022.07.005